PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Researchers advocate for structured framework to study the benefits of exercise training in multiple sclerosis rehabilitation

Using the experimental medicine framework will speed the development of evidence-based protocols that enhance rehabilitation outcomes

Researchers advocate for structured framework to study the benefits of exercise training in multiple sclerosis rehabilitation
2024-05-23
(Press-News.org) East Hanover, NJ – May 22, 2024 – A team of experts in multiple sclerosis (MS) research recommends a structured approach to the study of mechanisms of exercise training for improving outcomes for multiple sclerosis (MS). In a review article, “Focusing on neural mechanisms of exercise training benefits in multiple sclerosis,” (doi: 10.1016/j.msard.2024.105633) published in Multiple Sclerosis and Related Disorders on April 16, 2024, they emphasize the value of adopting an experimental medicine framework to optimize the development, evaluation, and application of exercise interventions in MS rehabilitation.

MS is a chronic and often disabling disease of the central nervous system (CNS) that impairs motor and cognitive function, affecting millions of individuals globally. Although pharmacological treatments are effective for preventing MS relapses, they are not designed for improving functions that are negatively impacted by the disease. Exercise training has been identified as an effective intervention with the potential to improve the neurological symptoms of MS. However, its potential has not been fully realized due to inconsistent methodologies in the field of exercise science and a lack of understanding of underlying mechanisms.

“By understanding how exercise affects CNS function in MS, we can design and optimize interventions that improve mobility, cognition, and quality of life,” said lead author Brian M. Sandroff, PhD, assistant director of the Center for Neuropsychology and Neuroscience Research at Kessler Foundation, and director of the Center’s Exercise Neurorehabilitation Research Laboratory.

In the article, Sandroff and colleagues review current literature on exercise training in MS and outline an experimental medicine framework as a pathway to accelerate progress at a field-wide level for better integrating exercise training into MS rehabilitation protocols. This framework comprises four main steps: identifying CNS targets for intervention, selecting outcomes that reflect the CNS targets, developing interventions that modulate those targets, and conducting robust clinical trials to precisely determine the extent to which changes in the CNS targets are the reason for exercise-related improvements in clinical outcomes.

“Adopting this framework and collaborating across disciplines fosters communication between basic research and clinical applications, helping practitioners translate findings into real-world therapeutic interventions,” Dr. Sandroff summarized. “This systematic approach will increase our progress toward evidence-based protocols, ultimately enhancing exercise rehabilitation outcomes for people with MS,” he concluded.

Citation:

Sandroff BM, Motl RW, Salter A. (2024). Exercise training and the central nervous system in multiple sclerosis: Moving the field forward through the application of an experimental medicine framework. Multiple Sclerosis and Related Disorders. Volume 86, 2024, 105633

Learn about the Foundation’s ongoing studies in MS rehabilitation research at https://kesslerfoundation.org/MSresearchstudies, or contact ResearchStudies@KesslerFoundation.org

About Kessler Foundation
Kessler Foundation, a major nonprofit organization in the field of disability, is a global leader in rehabilitation research. Our scientists seek to improve cognition, mobility, and long-term outcomes, including employment, for adults and children with neurological and developmental disabilities of the brain and spinal cord including traumatic brain injury, spinal cord injury, stroke, multiple sclerosis, and autism. Kessler Foundation also leads the nation in funding innovative programs that expand opportunities for employment for people with disabilities. For more information, visit KesslerFoundation.org.

Press Contacts at Kessler Foundation:
Deborah Hauss, DHauss@kesslerfoundation.org;
Carolann Murphy, CMurphy@KesslerFoundation.org.

Stay Connected with Kessler Foundation
X (formerly known as Twitter) | Facebook | YouTube | Instagram | SoundCloud

 

 

 

END

[Attachments] See images for this press release:
Researchers advocate for structured framework to study the benefits of exercise training in multiple sclerosis rehabilitation Researchers advocate for structured framework to study the benefits of exercise training in multiple sclerosis rehabilitation 2 Researchers advocate for structured framework to study the benefits of exercise training in multiple sclerosis rehabilitation 3

ELSE PRESS RELEASES FROM THIS DATE:

Researchers detect hidden threats with advanced x-ray imaging

Researchers detect hidden threats with advanced x-ray imaging
2024-05-23
WASHINGTON — Researchers have combined various x-ray imaging technologies to create multi-contrast images that can be used to detect threatening materials such as explosives in thousands of complicated scenarios. The new approach, which also leverages readily available machine learning procedures for materials classification, could be useful for security screening as well as applications in the life and physical sciences. “This method is particularly well suited to discriminating objects with very ...

Hypertension and kidney function after living kidney donation

2024-05-23
About The Study: In this cohort study of living kidney donors and nondonors with the same follow-up schedule, the risks of hypertension and albuminuria were not significantly different. After the initial drop in estimated glomerular filtration rate (eGFR) from nephrectomy, donors had a slower mean rate of eGFR decline than nondonors but were more likely to have an eGFR between 30 and 60 mL/min/1.73 m2 at least once in follow-up.  Corresponding Author: To contact the corresponding author, Amit X. Garg, M.D., Ph.D., email amit.garg@lhsc.on.ca. To access the embargoed study: Visit our For The Media website ...

Kidney transplant outcomes from deceased donors who received dialysis

2024-05-23
About The Study: Compared with receiving a kidney from a deceased donor who did not undergo dialysis, receiving a kidney from a deceased donor who underwent dialysis prior to kidney donation was associated with a significantly higher incidence of delayed graft function, but no significant difference in graft failure or death at follow-up.  Corresponding Author: To contact the corresponding author, Chirag R. Parikh, M.D., Ph.D., email chirag.parikh@jhmi.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jama.2024.8469) Editor’s Note: Please see ...

Potentially habitable 'exo-Venus' with Earth-like temperature discovered

Potentially habitable exo-Venus with Earth-like temperature discovered
2024-05-23
Potentially habitable 'exo-Venus' with Earth-like temperature discovered Royal Astronomical Society press release RAS PR 24/12 Embargoed until 15:00 BST on Thursday 23 May 2024   Astronomers have made the rare and tantalising discovery of an Earth-like exoplanet 40 light-years away that may be just a little warmer than our own world. The potentially-habitable planet, named Gliese 12 b, orbits its host star every 12.8 days, is comparable in size to Venus - so slightly smaller than ...

Earth twin or evil twin

Earth twin or evil twin
2024-05-23
The discovery of a planet similar to Venus around a star in the neighborhood of the Solar System raises hopes that astronomers may someday unlock the secret to why life appeared on Earth. The study of life in the Universe is difficult because we have only one example of a planet where life has been confirmed: Earth. It is difficult to say which characteristics of Earth are required for life to appear, and which are irrelevant. Until we find an “Earth twin” where the conditions for life also appeared, the best astronomers ...

Tracking down the genetic causes of lupus to personalize treatment

Tracking down the genetic causes of lupus to personalize treatment
2024-05-23
Lupus is a lifelong, often painful and occasionally lethal autoimmune disease. Few treatments exist today beyond powerful steroids to knock down a patient's immune system — a therapy that has its own serious risks. The good news is that new and promising treatments are in clinical trials. But the term lupus belies the fact that the disease has a variety of causes, which means that treatments will have to be highly personalized to guarantee that each patient is given the drug that targets the specific genetic mutation ...

New discoveries about the nature of light could improve methods for heating fusion plasma

New discoveries about the nature of light could improve methods for heating fusion plasma
2024-05-23
Both literally and figuratively, light pervades the world. It banishes darkness, conveys telecommunications signals between continents and makes visible the invisible, from faraway galaxies to the smallest bacterium. Light can also help heat the plasma within ring-shaped devices known as tokamaks as scientists worldwide strive to harness the fusion process to generate green electricity. Now, scientists have made discoveries about light particles known as photons that could aid the quest for fusion ...

Lehigh University researchers explore innovative cable-based approach to aerial robotics

Lehigh University researchers explore innovative cable-based approach to aerial robotics
2024-05-23
When we think about drones, we tend to think about Amazon. But their potential is much greater, and arguably far more important, than dropping off a box of laundry pods by lunchtime (an idea that’s struggled to take off since Jeff Bezos floated it more than a decade ago).  Aerial robots could be a huge asset, saving time, money, and workers’ well-being, in industries like construction where humans often have to heft materials up multiple floors, says David Saldaña, an assistant professor of computer science and engineering. They could also deliver ...

Researcher charges ahead with new tech to power drones wirelessly

Researcher charges ahead with new tech to power drones wirelessly
2024-05-23
Dr. Ifana Mahbub, assistant professor of electrical and computer engineering at The University of Texas at Dallas, has been awarded the Defense Advanced Research Projects Agency (DARPA) Director’s Fellowship to continue her research to develop wireless technology to recharge unmanned aerial vehicles (UAVs) in flight. DARPA awards the fellowships to its Young Faculty Award recipients who demonstrate exceptional performance. Mahbub received a Young Faculty Award, which provided $500,000 over ...

Features of bloodstream infection among immunocompromised oncology patients presenting to the emergency department with fever

2024-05-23
Background and Aims Oncology patients undergoing cancer treatment and experiencing episodes of fever are known to be at increased risk for invasive bacterial infection, including bloodstream infection. This study aimed to identify the incidence of bacteremia along with the bloodstream isolates for immunocompromised oncology patients referred to the emergency department (ED) due to fever.   Methods Oncology patients with fever were referred to the ED according to a protocol previously reported. Virtually ...

LAST 30 PRESS RELEASES:

New jab protects babies from serious lung infection, study shows

July Tip Sheet from Sylvester Comprehensive Cancer Center

Current application status and innovative development of surgical robot

Counterfeited in China: New book assesses state of industry and its future

Machine learning reveals historical seismic events in the Yellowstone caldera

First analyses of Myanmar earthquake conclude fault ruptured at supershear velocity

Curved fault slip captured on CCTV during Myanmar earthquake

Collaboration rewarded for work to further deployment of batteries in emerging economies

Heart-healthy habits also prevent cancer, Alzheimer’s, COPD, other diseases, Emory study finds

Scientists will use a $1M grant to build a support system addressing sea level rise and flooding in South Florida

New research examines how pH impacts the immune system

Inhaled agricultural dust disrupts gut health

New study reveals hidden regulatory roles of “junk” DNA

Taking the sting out of ulcerative colitis

Deep life’s survival secret: Crustal faulting generates key energy sources, study shows

Idaho National Laboratory to lead advancements in US semiconductor manufacturing

AI-assisted sorting, other new technologies could improve plastic recycling

More than just larks and owls!

Call for nominations: 2026 Dan David Prize

New tool gives anyone the ability to train a robot

Coexistence of APC and KRAS mutations in familial adenomatous polyposis and endometrial cancer: A mini-review with case-based perspective

First global-to-local study reveals stark health inequalities from COVID-19 in 2020–2021

rcssci: Simplifying complex data relationships with enhanced visual clarity

Why some ecosystems collapse suddenly—and others don’t

One-third of U.S. public schools screen students for mental health issues

GLP-1 RA use and survival among older adults with cancer and type 2 diabetes

Trends in physician exit from fee-for-service Medicare

Systematic investigation of tumor microenvironment and antitumor immunity with IOBR

Common feature between forest fires and neural networks reveals the universal framework underneath

New R package revolutionizes gene set enrichment analysis visualization for biomedical research

[Press-News.org] Researchers advocate for structured framework to study the benefits of exercise training in multiple sclerosis rehabilitation
Using the experimental medicine framework will speed the development of evidence-based protocols that enhance rehabilitation outcomes