PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

The KIT ligand KITLG promotes portal vein tumor thrombosis by up-regulating COL4A1 through STAT3-SMAD2 signaling in hepatocellular carcinoma

2024-06-17
(Press-News.org) https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0049

Announcing a new publication for Acta Materia Medica journal. Portal vein tumor thrombosis (PVTT), a severe complication of hepatocellular carcinoma (HCC), markedly influences patient prognosis by fostering a hypercoagulable state. However, its molecular underpinnings remain largely unexplored. This study sheds light on the critical role of the KIT ligand (KITLG) in modulating expression of the collagen gene COL4A1 via the STAT3-SMAD2 signaling pathway, thereby influencing platelet activation and PVTT development. Extensive analysis of PVTT tissue samples, alongside in vitro and in vivo experiments including cell-platelet interaction assays and PVTT animal models, revealed the mechanism through which KITLG regulates COL4A1 expression, as well as its downstream effects on platelet behavior and the coagulation cascade. Our findings revealed that marked upregulation of COL4A1 expression, mediated by KITLG through the STAT3-SMAD2 pathway, led to increased platelet activation and PVTT formation. KITLG and COL4A1 expression was markedly higher in PVTT tissues than primary HCC tissues, thus highlighting their critical role in the pathophysiological trajectory leading to thrombosis. The finding that the KITLG-COL4A1 signaling axis is a crucial mediator in PVTT development may offer promising new directions for developing targeted diagnostic and therapeutic strategies. This study underscores the importance of the KITLG-COL4A1 axis in PVTT formation and its potential as a therapeutic target in HCC treatment protocols.

# # # # # #

Acta Materia Medica welcomes the submission of research articles, review articles, databases, mini reviews, commentaries, editorials, short communications, case report articles and study protocols.

Submission Process

Submissions to Acta Materia Medica are made using ScholarOne, the online submission and peer review system. Registration and access are available at https://mc04.manuscriptcentral.com/ammed

Queries about the journal can be sent to editorialoffice@amm-journal.org.

Please visit https://amm-journal.org/ to learn more about the journal.

Editorial Board: https://amm-journal.org/index.php/editorial-board/

There are no author submission or article processing fees.

 

Follow Acta Materia Medica on Twitter https://twitter.com/AMM_journal; Facebook (https://www.facebook.com/AMMjournal)

eISSN 2737-7946

# # # # # #

Feifei Mao, Yuqiang Cheng and Kang Wang et al. The KIT ligand KITLG promotes portal vein tumor thrombosis by up-regulating COL4A1 through STAT3-SMAD2 signaling in hepatocellular carcinoma. Acta Materia Medica. 2024. Vol. 3(2):207-225. DOI: 10.15212/AMM-2023-0049

END



ELSE PRESS RELEASES FROM THIS DATE:

Recent Georgia Tech grad earns ACM Doctoral Dissertation Award for creating devices that look like stickers and can harvest energy from the environment

Recent Georgia Tech grad earns ACM Doctoral Dissertation Award for creating devices that look like stickers and can harvest energy from the environment
2024-06-17
ACM, the Association for Computing Machinery, today announced that Nivedita Arora, of Northwestern University is the recipient of the ACM Doctoral Dissertation Award for her dissertation “Sustainable Interactive Wireless Stickers: From Materials to Devices to Applications,” which demonstrated wireless and batteryless sensor nodes using novel materials and radio backscatter. Arora’s research envisions creating sustainable computational materials that operate by harvesting energy from the environment and, at the end ...

Spinning up hurricane communications

2024-06-17
Forecasters can use images in social media to better communicate weather related hazards of hurricanes, according to a pair of new studies.  Scientists at the U.S. National Science Foundation National Center for Atmospheric Research (NSF NCAR) analyzed 2017 Twitter (now X) data related to two hurricanes – Harvey and Irma. The researchers found that forecast information communicated in the early stages of storm development, when the threat posed by a hurricane is uncertain, sets the stage for how people react to subsequent ...

How the ketogenic diet improves healthspan and memory in aging mice

2024-06-17
The ketogenic diet has its fanatics and detractors among dieters, but either way, the diet has a scientifically documented impact on memory in mice. Whlie uncovering how the high fat, low carbohydrate diet boosts memory in older mice, Buck scientists and a team from the University of Chile identified a new molecular signaling pathway that improves synapse function and helps explain the diet’s benefit on brain health and aging. Published in the June 5, 2024 issue of Cell Reports Medicine, the findings provide new directions for targeting the memory effects on a molecular level, without requiring a ketogenic diet or even the byproducts of it. “Our ...

Brazilian scientists develop functional bread to help prevent asthma

Brazilian scientists develop functional bread to help prevent asthma
2024-06-17
Brazilian researchers have developed functional bread with the potential to prevent asthma, a respiratory disorder responsible for some 350,000 hospitalizations per year in the SUS (Sistema Único de Saúde), the nation’s public healthcare network. The formulation, for which a patent application has been filed in Brazil (BR1020210266465), is described in an article published in the journal Current Developments in Nutrition. It contains Saccharomyces cerevisiae UFMG A-905, ...

Potential new treatment option for diabetic retinopathy

2024-06-17
Potential New Treatment Option for Diabetic Retinopathy OU researcher developing potential new treatment for diabetic retinopathy that could address the problem much earlier. OKLAHOMA CITY, OKLA. – Patients with diabetes face a host of potential health problems as they work to manage the chronic disease. Still, one concern that seems to weigh heavily is the risk of losing their sight through a condition known as diabetic retinopathy. Researchers at the University of Oklahoma Health Sciences and Memorial Sloan Kettering (MSK) Cancer Center are studying a new, revolutionary treatment for diabetic retinopathy that could change the prognosis ...

Paternal use of metformin during sperm production not associated with major birth defects

2024-06-17
Embargoed for release until 5:00 p.m. ET on Monday 17 June 2024     Annals of Internal Medicine Tip Sheet      @Annalsofim     Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not ...

American diets have a long way to go to achieve health equity

American diets have a long way to go to achieve health equity
2024-06-17
Poor diet continues to take a toll on American adults. It’s a major risk factor for obesity, type 2 diabetes, cardiovascular disease, and certain cancers, and more than one million Americans die every year from diet-related diseases, according to the Food and Drug Administration. Poor diet and food insecurity is also costly, attributing to an estimated $1.1 trillion in healthcare expenditures and lost productivity. These burdens also contribute to major health disparities by income, education, zip code, race, and ethnicity. In a study from the Food is Medicine Institute at the Friedman School of Nutrition Science and Policy at Tufts University published today in ...

New ‘aging atlas’ provides a detailed map of how cells and tissues age

2024-06-17
A new aging atlas gives scientists an in-depth view of how individual cells and tissues in worms age and how different lifespan-extending strategies might stop the clock. Aging impacts all the tissues in our body – from our muscles to our skin. Figuring out how individual tissues and cells age could help researchers better understand the aging process and aid in the development of anti-aging treatments. Due to their short lifespans, simple body plans, and genetic similarity to humans, many researchers study aging in roundworms. To look at aging at the level of tissues and cells, a team of researchers from HHMI's Janelia ...

New technology allows researchers to precisely, flexibly modulate brain

2024-06-17
By Beth Miller Human brain diseases, such as Parkinson’s disease, involve damage in more than one region of the brain, requiring technology that could precisely and flexibly address all affected regions simultaneously. Researchers at Washington University in St. Louis have developed a noninvasive technology combining a holographic acoustic device with genetic engineering that allows them to precisely target affected neurons in the brain, creating the potential to precisely modulate selected cell ...

Origins of cumulative culture in human evolution

Origins of cumulative culture in human evolution
2024-06-17
Each of us individually is the accumulated product of thousands of generations that have come before us in an unbroken line. Our culture and technology today are also the result of thousands of years of accumulated and remixed cultural knowledge. But when did our earliest ancestors begin to make connections and start to build on the knowledge of others, setting us apart from other primates? Cumulative culture — the accumulation of technological modifications and improvements over generations — allowed humans to adapt to a diversity of environments and challenges. But, it is unclear when cumulative culture first developed during hominin evolution. A study published ...

LAST 30 PRESS RELEASES:

Mount Sinai-Duke University study identifies DNA variants that increase testosterone production in PCOS patients

Physiology-guided complete revascularization in older patients with myocardial infarction

Metals and sulfate in air pollution mixture may contribute most to asthma hospitalizations

Understanding the profound yet hidden effects of neglect on white matter structures

SEOULTECH researchers develop revolutionary 3D-printed smart materials create high-performance pressure sensors for wearables

Pusan National University scientists develop self-deploying material for next-gen robotics

Remote screening for asymptomatic atrial fibrillation

Inflammation may explain why women with no standard modifiable risk factors have heart attacks and strokes

Unusual carbon dioxide-rich disk detected around young star challenges planet formation models

Treetop Tutorials: Orangutans learn how to build their beds by peering at others and a lot of practice!

Scientists uncover key protein in cellular fat storage

Study finds significant health benefits from gut bugs transfer

UC Riverside pioneers way to remove private data from AI models

Total-body PET imaging takes a look at long COVID

Surgery to treat chronic sinus disease more effective than antibiotics

New online tool could revolutionize how high blood pressure is treated

Around 90% of middle-aged and older autistic adults are undiagnosed in the UK, new review finds

Robot regret: New research helps robots make safer decisions around humans

Cells ‘vomit’ waste to promote healing, mouse study reveals

Wildfire mitigation strategies can cut destruction by half, study finds

Sniffing out how neurons are made

New AI tool identifies 1,000 ‘questionable’ scientific journals

Exploring the promise of human iPSC-heart cells in understanding fentanyl abuse

Raina Biosciences unveils breakthrough generative AI platform for mRNA therapeutics featured in Science

Yellowstone’s free roaming bison drive grassland resilience

Turbulent flow in heavily polluted Tijuana River drives regional air quality risks

Revealed: Genetic shifts that helped tame horses and made them rideable

Mars’ mantle is a preserved relic of its ancient past, seismic data reveals

Variation inside and out: cell types in fruit fly metamorphosis

Mount Sinai researchers use AI and lab tests to predict genetic disease risk

[Press-News.org] The KIT ligand KITLG promotes portal vein tumor thrombosis by up-regulating COL4A1 through STAT3-SMAD2 signaling in hepatocellular carcinoma