Bilateral mastectomy and breast cancer mortality

JAMA Oncology

2024-07-25

(Press-News.org) About The Study: This cohort study indicates that the risk of dying of breast cancer increases substantially after experiencing a contralateral breast cancer. Women with breast cancer treated with bilateral mastectomy had a greatly diminished risk of contralateral breast cancer; however, they experienced similar mortality rates as patients treated with lumpectomy or unilateral mastectomy.

Corresponding Author: To contact the corresponding author, Steven A. Narod, M.D., email steven.narod@wchospital.ca.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamaoncol.2024.2212)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2024.2212?guestAccessKey=bf61e8ab-0bc8-48e7-baa5-b4fa1120681b&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=072524

END

ELSE PRESS RELEASES FROM THIS DATE:

Antisense oligonucleotide treatment shows promise in treating Parkinson's disease progression

2024-07-25

TMDU researchers demonstrate proof of concept of antisense nucleic acid therapy to prevent the spread of α-synuclein pathologies in synucleinopathies. Tokyo, Japan – Parkinson’s disease (PD), as well as many other neurodegenerative disorders, has shown a link between the abnormal aggregation of a protein called α-synuclein (aSyn) and neuronal death. These aggregates, known as Lewy bodies and Lewy neurites depending on their subcellular localization, can spread by continuously causing normal endogenous aSyn to misfold. The complex nature of this aggregation process poses significant challenges ...

Intelligent engineering: AI transforms spatial arrangement of hydropower underground facilities

2024-07-25

Designing the spatial arrangement of underground powerhouses involves numerous complex parameters and boundaries, requiring frequent reference to various cases and specifications. Traditional methods struggle to efficiently retrieve this information, leading to suboptimal designs and extended project timelines. Due to these challenges, there is a pressing need for a more intelligent and efficient approach to streamline the design process, enhance accuracy, and improve project management in hydropower engineering. Researchers from Tianjin University, in collaboration with PowerChina Kunming Engineering Corporation Limited and other ...

Unlocking new potential in solar tech: dimethyl acridine enhances perovskite solar cells

2024-07-25

Perovskite solar cells (PSCs) are highly regarded for their exceptional performance and straightforward fabrication. However, traditional hole transport layers (HTLs) like Poly (triarylamine) (PTAA), Nickel Oxide (NiOx), and poly (3,4-ethylenedioxythiophene)-poly (styrenesulfonate) (PEDOT) have inherent limitations that impede efficiency and stability. These materials often suffer from issues such as hydrophobicity, high reactivity, and acidity, which negatively affect the overall performance of PSCs. Due to these challenges, there is a pressing ...

Harnessing blue energy: advanced nanofluidic membranes boost aquatic energy conversion efficiency

2024-07-25

To achieve carbon neutrality, advancements in energy conversion and storage technologies are essential. Current aqueous energy devices suffer from performance limitations due to the trade-off between permeability and selectivity in permselective membranes. This trade-off hampers the efficiency of energy conversion and storage systems, necessitating the development of membranes that can balance these properties effectively. Due to these challenges, further research is required to explore innovative membrane structures that can enhance the performance of energy conversion and storage devices. A research team from Tsinghua University has published a study (DOI: 10.26599/EMD.2024.9370041) ...

Unlocking solar efficiency: a leap in perovskite solar cell technology

2024-07-25

Perovskite solar cells (PSCs) are celebrated for their exceptional photovoltaic performance and affordability. However, the high cost of charge transport materials remains a major obstacle to their commercialization. Conventional materials like 2,2',7,7'-Tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9'-spirobifluorene (Spiro-OMeTAD), are expensive and complex to produce. Therefore, developing low-cost, efficient alternatives is essential to make PSCs more economically viable. Addressing these issues is crucial for advancing solar technology and achieving broader adoption. Hence, this study focuses ...

An effective strategy to inhibit grain coarsening: Construction of multi-element co-segregated grain boundary complexion

2024-07-25

To date, ceramic scientists have devised various strategies to impede grain coarsening. The utilization of nano-sized precursor powder can not only facilitate the densification process, but also yields bulk ceramics with reduced grain sizes compared with micron-sized precursor powder. Rapid sintering by passes the low-temperature surface diffusion stage and directly enters the high-temperature sintering stage through rapid heating, rendering it an effective way to inhibit grain coarsening. However, these aforementioned strategies fail to prevent coarsening during the application of nano-ceramics in medium- ...

Insilico releases AI-powered hardware platform, PandaOmics Box for on-premise drug discovery and personalized medicine research

2024-07-25

The development of innovative medicines is an expensive, time-consuming and risky business. On average, it usually takes at least a decade and billions of dollars to bring a new drug from project initiation to approval. Identifying effective targets and conducting biological analysis is the first step in the process and remains a top priority in drug development. To facilitate for maximum data privacy and data security, Insilico Medicine ("Insilico"), developed a hardware platform, PandaOmics Box, that does not require Internet access and allows for on-premise biological analytics, target identification, biomarker ...

RSNA makes strides in narrowing radiology gender gap

2024-07-25

OAK BROOK, Ill. – The radiology gender gap is decreasing, but there remains work to be done, according to an editorial published today in RadioGraphics, a journal of the Radiological Society of North America (RSNA). In 2022, nearly half of residents and fellows in Accreditation Council for Graduate Medical Education (ACGME)–accredited programs were female. However, less than 27% of active diagnostic radiologists and only 10% of active interventional radiologists are female. Within the 48 largest medical specialty groups, diagnostic radiology ranks 41st and ...

Vital support for early career researchers in aging boosted with Hearst Foundations gift to American Federation for Aging Research (AFAR)

2024-07-25

NEW YORK, NY– The American Federation for Aging Research (AFAR) is pleased to announce a $450,000 grant from The Hearst Foundations in support of the Grants for Junior Faculty program. The Grants for Junior Faculty provide early career investigators with up to $150,000 for one to two years to support research focused on aging processes and age-related diseases. The $450,000 grant from Hearst Foundations will fully underwrite three Grants for Junior Faculty over the next three years. Selected ...

Nonreciprocal interactions go nonlinear

2024-07-25

Using two optically trapped glass nanoparticles, researchers observed a novel collective Non-Hermitian and nonlinear dynamic driven by nonreciprocal interactions. This contribution expands traditional optical levitation with tweezer arrays by incorporating the so called non-conservative interactions. Their findings, supported by an analytical model developed by collaborators from Ulm University and the University of Duisburg-Essen, were recently published in Nature Physics. Fundamental forces like gravity and electromagnetism are reciprocal, meaning two ...

Modular assembly of chiral nitrogen-bridged rings achieved by palladium-catalyzed diastereoselective and enantioselective cascade cyclization reactions

Bilateral mastectomy and breast cancer mortality

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: