(Press-News.org) About The Study: The amyloid probability score 2 (APS2) blood test and percentage of p-tau217 alone had high diagnostic accuracy for identifying Alzheimer disease among individuals with cognitive symptoms in primary and secondary care using predefined cutoff values. Future studies should evaluate how the use of blood tests for these biomarkers influences clinical care.
Corresponding Authors: To contact the corresponding authors, email Sebastian Palmqvist, M.D., Ph.D. (sebastian.palmqvist@med.lu.se) and Oskar Hansson, M.D., Ph.D. (oskar.hansson@med.lu.se).
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jama.2024.13855)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Media advisory: This study is being presented at the Alzheimer’s Association International Conference.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.13855?guestAccessKey=afaed68f-23d4-42cd-9123-49b9201851c6&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=072824
END
Blood biomarkers to detect Alzheimer disease in primary care and secondary care
JAMA
2024-07-28
ELSE PRESS RELEASES FROM THIS DATE:
Changes in Alzheimer disease blood biomarkers and associations with incident all-cause dementia
2024-07-28
About The Study: Plasma biomarkers of Alzheimer disease (AD) neuropathology, neuronal injury, and astrogliosis increase with age and are associated with known dementia risk factors. AD-specific biomarkers’ association with dementia starts in midlife whereas late-life measures of AD, neuronal injury, and astrogliosis biomarkers are all associated with dementia.
Corresponding Author: To contact the corresponding author, Priya Palta, Ph.D., M.H.S., email priya_palta@med.unc.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jama.2024.6619)
Editor’s ...
New and improved drug delivery molecules for skeletal muscle
2024-07-27
Tokyo, Japan – Researchers from Tokyo Metropolitan University have created a new drug delivering molecule, a zwitterionic polymer complex that can help get plasmid DNA inside cells when injected into skeletal muscle, a crucial step in the expression of therapeutic RNA and proteins. The new compound effectively bound to plasmid DNA without affecting its structure. Injected into mouse muscles, the team observed widespread gene expression, promising applications to treatments of serious muscle diseases.
Drug delivery systems underpin many of the clinical breakthroughs of our age. For example, ...
UC San Diego Health ends negotiations with Tri-City Medical Center Healthcare District
2024-07-27
UC San Diego Health has ended more than nine months of negotiations for a potential partnership with the Tri-City Medical Center (TCMC) Healthcare District.
A final revised offer was presented to the TCMC Healthcare District on July 24 and no agreement was reached.
Highlights of the final proposal for TCMC included a financial recovery and growth plan that included:
$100 million infusion of cash within the first two years plus other financial supports, including a line of credit designed to protect the financial stability of TCMC during the first five years.
All assets and liabilities would transfer to UC San Diego Health, including employment ...
MLB add lifesavers to the chain of survival in New York City
2024-07-27
NEW YORK CITY, July 26, 2024 — The American Heart Association and Major League Baseball (MLB) brought cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED) training to MLB staff at the New York headquarters office located on Avenue of the Americas on Monday, July 22. Nearly 100 employees attended to learn the lifesaving skills building confidence and capabilities to respond in the event of a cardiac emergency. According to American Heart Association data, nine out of every ten people who experience cardiac arrest outside of a hospital die, in part because they do not receive immediate CPR more than half of the time. CPR, especially if performed ...
ISU studies explore win-win potential of grass-powered energy production
2024-07-27
AMES, Iowa – Strategically planting perennial grass throughout corn and soybean fields helps address the unintended environmental consequences of growing the dominant row crops, including soil erosion, fertilizer runoff and greenhouse gas emissions.
But converting portions of farmland back to prairie has to make financial sense for farmers, which is why a research team led by Iowa State University landscape ecologist Lisa Schulte Moore has spent the past six years studying how to efficiently turn harvested ...
Study identifies biomarker that could predict whether colon cancer patients benefit from chemotherapy
2024-07-27
MIAMI, FLORIDA (July 25, 2024) – Many people with stage II or III colon cancer receive additional, or adjuvant, chemotherapy following surgery. However, clinical trials have shown that this treatment doesn’t improve the chances of survival for every patient. A study published July 25 in Cell Reports Medicine identifies and validates a 10-gene biomarker that potentially predicts whether a stage II or III colon cancer patient will benefit from adjuvant chemotherapy.
A secondary finding from the study could also lead to further research and application. Researchers found that the gene signature could potentially also predict ...
Children are less likely to have type 1 diabetes if their mother has the condition than if their father is affected
2024-07-27
New research to be presented at this year’s Annual Meeting of the European Association for the Study of Diabetes (EASD) (Madrid, 9-13 September) shows that a child is almost twice as likely to develop type 1 diabetes (T1D) if their father has the condition, than if their mother has the condition.
The study, the largest of its kind, suggests that exposure to T1D in the womb confers long-term protection against the condition in children with affected mothers relative to those with affected fathers.
Understanding what is responsible for this relative protection could lead to opportunities ...
Two shark species documented in Puget Sound for first time by Oregon State researchers
2024-07-26
CORVALLIS, Oregon – Oregon State University researchers have made the first scientific confirmation in Puget Sound of two distinct shark species, one of them critically endangered.
The presence of the broadnose sevengill shark and endangered soupfin shark in the sound, the southern portion of the Salish Sea, may indicate changes in what biologists in OSU’s Big Fish Lab describe as an economically, culturally and ecologically valuable inland waterway.
The Salish Sea separates northwest Washington from British Columbia’s Vancouver Island. The ...
AI method radically speeds predictions of materials’ thermal properties
2024-07-26
CAMBRIDGE, MA — It is estimated that about 70 percent of the energy generated worldwide ends up as waste heat.
If scientists could better predict how heat moves through semiconductors and insulators, they could design more efficient power generation systems. However, the thermal properties of materials can be exceedingly difficult to model.
The trouble comes from phonons, which are subatomic particles that carry heat. Some of a material’s thermal properties depend on a measurement called the phonon ...
Study: When allocating scarce resources with AI, randomization can improve fairness
2024-07-26
CAMBRIDGE, MA – Organizations are increasingly utilizing machine-learning models to allocate scarce resources or opportunities. For instance, such models can help companies screen resumes to choose job interview candidates or aid hospitals in ranking kidney transplant patients based on their likelihood of survival.
When deploying a model, users typically strive to ensure its predictions are fair by reducing bias. This often involves techniques like adjusting the features a model uses to make decisions or calibrating the scores it generates.
However, researchers from MIT and Northeastern University argue that these fairness ...
LAST 30 PRESS RELEASES:
New antibody-drug conjugate shows promising efficacy in EGFR-mutated NSCLC patients
Iza-Bren in combination with osimertinib shows 100% response rate in EGFR-mutated NSCLC, phase II study finds
COMPEL study shows continuing osimertinib treatment through progression with the addition of chemotherapy improves progression-free survival in EGFR-mutated NSCLC
CheckMate 77T: Nivolumab maintains quality of life and reduces symptom deterioration in resectable NSCLC
Study validates AI lung cancer risk model Sybil in predominantly Black population at urban safety-net hospital
New medication lowered hard-to-control high blood pressure in people with chronic kidney disease
Innovative oncolytic virus and immunotherapy combinations pave the way for advanced cancer treatment
New insights into energy metabolism and immune dynamics could transform head and neck cancer treatment
Pennington Biomedical’s Dr. Steven Heymsfield named LSU Boyd Professor – LSU’s highest faculty honor
Study prompts new theory of human-machine communication
New method calculates rate of gene expression to understand cell fate
Researchers quantify rate of essential evolutionary process in the ocean
Innovation Crossroads companies join forces, awarded U.S. Air Force contract
Using new blood biomarkers, USC researchers find Alzheimer’s disease trial eligibility differs among various populations
Pioneering advances in in vivo CAR T cell production
Natural medicines target tumor vascular microenvironment to inhibit cancer growth
Coral-inspired pill offers a new window into the hidden world of the gut
nTIDE September2025 Jobs Report: Employment for people with disabilities surpasses prior high
When getting a job makes you go hungry
Good vibrations could revolutionize assisted reproductive technology
More scrutiny of domestic fishing fleets at ports could help deter illegal fishing
Scientists transform plastic waste into efficient CO2 capture materials
Discovery of North America’s role in Asia’s monsoons offers new insights into climate change
MD Anderson and Phoenix SENOLYTIX announce strategic cross-licensing agreement to enhance inducible switch technologies for cell and gene therapies
Researchers discover massive geo-hydrogen source to the west of the Mussau Trench
Even untouched ecosystems are losing insects at alarming rates, new study finds
Adaptive visible-infrared camouflage with wide-range radiation control for extreme ambient temperatures
MD Anderson research highlights for September 5, 2025
Physicists create a new kind of time crystal that humans can actually see
Reminder: Final media invitation for EPSC-DPS2025 and details of media briefings on RAMSES and Juno missions
[Press-News.org] Blood biomarkers to detect Alzheimer disease in primary care and secondary careJAMA