Safety and risk assessment of no-prescription online semaglutide purchases

JAMA Network Open

2024-08-02

(Press-News.org) About The Study: This qualitative study found that semaglutide products are actively being sold without prescription by illegal online pharmacies, with vendors shipping unregistered and falsified products. Two websites evaluated were sent FDA warning letters for unlawful sale of unapproved and misbranded semaglutide. U.S. poison centers have reported a 1500% increase in calls related to semaglutide, highlighting the need for enhanced pharmacovigilance including for online sourcing harms.

Corresponding Author: To contact the corresponding author, Tim K. Mackey, MAS, PhD, email tkmackey@ucsd.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2024.28280)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.28280?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=080224

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Glycated hemoglobin A1c time in range and dementia in older adults with diabetes

2024-08-02

About The Study: The findings of this study suggest that for older adults with diabetes, maintaining hemoglobin A1c (HbA1c) stability in individualized target ranges over time is associated with a lower risk of Alzheimer disease and related dementias. Lower HbA1c time in range may identify patients at increased risk of Alzheimer disease and related dementias. Corresponding Author: To contact the corresponding author, Paul R. Conlin, MD, email paul.conlin@va.gov. To access the embargoed study: Visit our For The Media website at this ...

Mast cells trap and use living neutrophils during allergic reactions

2024-08-02

Inflammation is the body's response to harmful stimuli, characterized by heat, pain, redness, swelling, and loss of tissue function. When balanced, inflammation protects the body by clearing harmful agents and initiating tissue repair. However, excessive inflammation can cause tissue destruction and disease. Key players in this process are various immune cells, which work together during inflammation. The type of immune cells involved often varies depending on the harmful stimulus, influencing the outcome of the inflammatory response. Immune cell trapping during allergic responses Mast cells, residing in tissues and critical for initiating ...

Exploding popularity of Ozempic and Wegovy among privately insured patients may worsen disparities

2024-08-02

A new USC study suggests that publicly insured individuals who are most likely to benefit from new drugs for diabetes and obesity are less likely to get them than those with private insurance. Prescription fills for the drug best known as Ozempic or Wegovy — semaglutide — increased by more than 400% between January 2021 and December 2023, according to research out today in JAMA Health Forum. Approved first for type 2 diabetes, then for weight loss, studies show that semaglutide also improves blood pressure and reduces cardiovascular disease — problems that plague millions of Americans. Yet the lion’s share of prescriptions ...

Sizing up microplastics: Nanofiltration uncovers environmental bioactivity

2024-08-02

A new study reveals the bioactivity of microplastics in Lake Ontario using cutting-edge nanomembrane filtering technology. Researchers found all samples contained microplastics ranging between 8 and 20 µm. The study highlights varying bioactivity levels, such as aryl hydrocarbon receptor (AhR) activity and IL-6 levels, indicating potential health risks. These findings underscore the urgent need for further research to comprehend the impact of microplastics on human health and the environment. This pioneering approach offers fresh insights into tackling the challenges posed by microplastic pollution. Microplastics ...

What gave the first molecules their stability?

2024-08-02

The origins of life remain a major mystery. How were complex molecules able to form and remain intact for prolonged periods without disintegrating? A team at ORIGINS, a Munich-based Cluster of Excellence, has demonstrated a mechanism that could have enabled the first RNA molecules to stabilize in the primordial soup. When two RNA strands combine, their stability and lifespan increase significantly. In all likelihood, life on Earth began in water, perhaps in a tide pool that was cut off from seawater at low tide but flooded by waves at high tide. Over billions of years, complex molecules like DNA, RNA and proteins ...

Cold antimatter for quantum state-resolved precision measurements

2024-08-02

Why does the universe contain matter and (virtually) no antimatter? The BASE international research collaboration at the European Organisation for Nuclear Research (CERN) in Geneva, headed by Professor Dr Stefan Ulmer from Heinrich Heine University Düsseldorf (HHU), has achieved an experimental breakthrough in this context. It can contribute to measuring the mass and magnetic moment of antiprotons more precisely than ever before – and thus identify possible matter-antimatter asymmetries. BASE has developed a trap, which can cool individual antiprotons much more rapidly ...

Smart aggregates: The future of infrastructure health monitoring

2024-08-02

The proliferation of concrete infrastructure worldwide has been met with growing concerns over its durability and safety. Concrete structures are increasingly subjected to dynamic forces from natural disasters like earthquakes and environmental degradation, such as corrosion. These factors, coupled with the saturation of infrastructure projects, amplify the risks associated with structural failure. Consequently, there is a pressing need for effective structural health monitoring (SHM) systems that can preemptively identify and address these vulnerabilities. The ...

Synthesis of SiOC@C ceramic nanospheres with tunable electromagnetic wave absorption performance

2024-08-02

In recent years, microwave technology has dramatically progressed, marked by the arrival of the 5G era, owing to the advantages of electromagnetic waves in long-distance, wireless, and high-speed transmissions. However, electromagnetic wave pollution problems such as electromagnetic wave interference and electromagnetic wave radiation are becoming increasingly serious. Electromagnetic wave pollution not only affects the normal operation of electronic equipment, greatly threatens the information security of the scientific community, but also endangers human health and is a possible cause of cancer ...

NWSL add lifesavers to the chain of survival in New York City

2024-08-02

NEW YORK CITY, August 2, 2024 — According to American Heart Association data, nine out of every ten people who experience cardiac arrest outside of a hospital die, in part because they do not receive immediate CPR more than half of the time. CPR, especially if performed immediately, can double or triple a person’s chance of survival. That is why the American Heart Association and the National Women’s Soccer League (NWSL) brought cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED) training to NWSL staff at the New York headquarters office located on Madison ...

Solving the doping problem: Enhancing performance in Organic Semiconductors

2024-08-02

Cavendish physicists have discovered two new ways to improve organic semiconductors. They found a way to remove more electrons from the material than previously possible and used unexpected properties in an environment known as the non-equilibrium state, boosting its performance for use in electronic devices. “We really wanted to hit the nail and figure out what is happening when you heavily dope polymer semiconductors,’ said Dr Dionisius Tjhe, Postdoctoral Research Associate at the Cavendish Laboratory. Doping is the process of removing or adding electrons into a semiconductor, increasing its ability to ...

LAST 30 PRESS RELEASES:

Project to redesign clinical trials for neurologic conditions for underserved populations funded with $2.9M grant to UTHealth Houston

Menarini Group and Insilico Medicine enter a second exclusive global license agreement for an AI discovered preclinical asset targeting high unmet needs in oncology