(Press-News.org) HOUSTON ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Targeting an enzyme as part of combination therapy disrupts gastric cancer progression
Many patients with gastric cancer have metastatic disease at the time of diagnosis, highlighting a need to identify pathways that control malignant progression. Researchers led by Pawel Mazur, Ph.D., identified a previously unrecognized lysine methyltransferase, SMYD5, that is highly expressed in patients with gastric cancer and is associated with poorer outcomes. The researchers found that SMYD5 specifically methylates the rpL40 protein, which remodels a particular region on ribosomes, resulting in increased new protein formation and cancer growth. Inhibiting SMYD5 in patient-derived and genetically engineered lab models blocked cancer cell growth and sensitized them to targeted therapy treatment. Further, SMYD5 inhibition combined with targeted therapy and chimeric antigen receptor (CAR) T cell therapy effectively eliminated aggressive gastric cancer in vivo, supporting the therapeutic potential of this combination. Learn more in Nature.
ADC shows promising results in treating HER2+ metastatic colorectal cancer
HER2 is overexpressed in some colorectal cancers, contributing to poor prognosis, brain metastases and resistance to anti-EGFR therapies. Findings from the DESTINY-CRC01 study suggested that the HER2-targeted antibody-drug conjugate (ADC), trastuzumab deruxtecan, might benefit patients with HER2 positive, RAS-wild-type metastatic colorectal cancer. In the Phase II DESTINY-CRC02 trial, led by Kanwal Raghav, M.D., M.B.B.S., researchers evaluated the safety and efficacy of two doses of trastuzumab deruxtecan in 122 patients from multiple countries, all of whom had undergone chemotherapy and targeted treatments. The results showed that the lower dose had a 37.8% objective response rate, compared to 27.5% with the higher dose. Both doses were generally well tolerated, but the lower dose had fewer severe side effects. This study led to Food and Drug Administration approval of trastuzumab deruxtecan for HER2+ metastatic colorectal cancer, underscoring the ADC as an effective treatment option for this challenging cancer type. Learn more in The Lancet Oncology.
LIFR regulates cholesterol-driven process for liver regeneration
The liver is the only human organ that can fully regenerate, even after as much as 70% of it has been removed. New liver tissue can grow back to match the original organ’s size and functionality without turning into cancer, but how it does so remains unclear. White blood cells known as neutrophils recently have been implicated in this process, but the pathway involved in releasing neutrophils from the bone marrow after liver injury is poorly understood. Researchers led by Li Ma, Ph.D., uncovered new pathways orchestrated by leukemia inhibitory factor receptor (LIFR) to facilitate the regeneration process. When the liver is damaged, LIFR from hepatocytes – the most common liver cell type – promotes the production and secretion of cholesterol and the CXCL1 protein. While CXCL1 promotes the release of bone marrow neutrophils to the liver, cholesterol stimulates neutrophils to produce hepatocyte growth factor to induce hepatocyte proliferation. This novel role for cholesterol in the regenerative process of the liver could have potential clinical implications. Learn more in Nature Metabolism.
Novel biomarker can stratify patients with large cell neuroendocrine carcinoma
Patients with large cell neuroendocrine carcinoma (LCNEC) have few treatment options and poor prognoses, highlighting the need to identify more effective therapeutic targets. By examining molecular data from preclinical models and patients, researchers led by Carl Gay, M.D., Ph.D., uncovered two distinct types of LCNEC based on the presence of the transcription factor YAP1. YAP1-high and YAP1-low LCNEC have different genetic and gene expression features, underscoring the need for individually tailored treatments. YAP1-low tumors resemble small cell lung cancers (SCLC), including several proteins targeted by emerging SCLC treatments. Conversely, YAP1-high tumors exhibit features suggesting they would benefit from immunotherapies and targeted therapies most associated with non-small cell lung cancers. These results suggest that YAP1 status could guide the application, or even development, of personalized treatments for patients with LCNEC. Learn more in Clinical Cancer Research.
Novel BCL2 inhibitor shows promise in relapsed CLL
Patients with newly diagnosed chronic lymphocytic leukemia (CLL) respond well to the B cell lymphoma 2 (BCL2) inhibitor, venetoclax, as their initial treatment, but an increasing number of patients will relapse. Many of these relapsed patients retain sensitivity to BCL2 inhibitors and also have elevated levels of other anti-apoptotic proteins, such as B-cell lymphoma extra-large (BCLXL). To improve patient outcomes, researchers led by Deepa Sampath, Ph.D., examined the mechanism of action and activity of LP-118, a highly potent inhibitor of BCL2 with moderate BCLXL inhibition, in preclinical studies. Researchers observed reduction in tumor burden, survival advantages and low platelet toxicity. These results warrant further investigation and evaluation of the novel treatment in venetoclax-responsive and relapsed CLL. Learn more in Haematologica.
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NK cells expressing interleukin-21 show promising antitumor activity in glioblastoma cells
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MD Anderson research highlights for August 21, 2024
Featuring a combination treatment for gastric cancer, positive ADC results in colorectal cancer, and a new understanding of liver regeneration
2024-08-21
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In the realm of chronic inflammation, lipid abnormalities are well-recognized as pivotal contributors to the progression and clinical manifestations of atherosclerosis. Particularly in rheumatoid arthritis (RA), a systemic autoimmune disorder, the immune response leads to the generation of inflammatory cytokines that profoundly alter lipid and lipoprotein metabolism. This review article delves into the latest research exploring the impact of inflammation on proatherogenic disorders of lipid and lipoprotein metabolism in RA patients, with a focus on proinflammatory cytokines.
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New research has revealed factories globally are not properly destroying one of the most potent greenhouse gases emitted from the production of fluoropolymers like Teflon, and refrigerants.
The study investigated a known disparity between real and reported emissions of this gas, prompting calls for more countries to sign up to official agreements to limit emissions and for their Teflon factories to be independently audited to ensure compliance.
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A new study that examined health data on 18 million people reveals higher incidence of mental illnesses for up to a year following severe COVID-19 in unvaccinated people. Vaccination appeared to mitigate the adverse effects of COVID-19 on mental illnesses. The University of Bristol-led study, published in JAMA Psychiatry today [21 August], investigated associations of COVID-19 with mental illnesses according to time since diagnosis and vaccination status.
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Nearly 90 percent of NYC transit workers have been harassed or assaulted
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The COVID-19 pandemic brought an increase in crime to New York City’s subways and buses. The transit system’s employees—especially female workers—have frequently been on the receiving end of attacks, according to a new study published in the Journal of Urban Health.
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New heaviest exotic antimatter nucleus
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UPTON, N.Y. — Scientists studying the tracks of particles streaming from six billion collisions of atomic nuclei at the Relativistic Heavy Ion Collider (RHIC) — an “atom smasher” that recreates the conditions of the early universe — have discovered a new kind of antimatter nucleus, the heaviest ever detected. Composed of four antimatter particles — an antiproton, two antineutrons, and one antihyperon — these exotic antinuclei are known as antihyperhydrogen-4.
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About The Study: Chronic absenteeism rates were substantially higher in school districts that used virtual learning during the COVID-19 pandemic compared with in person in this cross-sectional study. Understanding how to reduce chronic absenteeism and use virtual learning without potentially negative consequences are key policy questions moving forward.
Corresponding Author: To contact the corresponding author, William N. Evans, PhD, email wevans1@nd.edu.
To access the embargoed study: ...
Self-repairing mitochondria use novel recycling system, study finds
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Mitochondria are tiny structures inside of cells that carry out a wide range of critical functions, including generating energy to help keep cells healthy. Every mitochondrion has two layers of membranes: the outer membrane and the inner membrane. On the inner membrane, folds called cristae contain proteins and molecules needed for energy production. ...
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[Press-News.org] MD Anderson research highlights for August 21, 2024Featuring a combination treatment for gastric cancer, positive ADC results in colorectal cancer, and a new understanding of liver regeneration