Lesion-level effects of LDL-C–lowering therapy in patients with acute myocardial infarction

JAMA Cardiology

2024-09-02

(Press-News.org) About The Study: At the lesion level, very intensive lipid-lowering therapy induced substantially greater percent atheroma volume regression than described in previous vessel-level analyses. Compared with statin therapy alone, alirocumab treatment was associated with greater enlargement of the lesion minimum lumen area and more frequent transition of presumably high-risk plaque phenotypes into more stable, less lipid-rich plaque phenotypes.

Corresponding Author: To contact the corresponding author, Lorenz Raber, MD, PhD, email lorenz.raeber@insel.ch.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamacardio.2024.3200)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.

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Media advisory: This study is being presented at the European Society of Cardiology Congress 2024.

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