Lesion-level effects of LDL-C–lowering therapy in patients with acute myocardial infarction

JAMA Cardiology

2024-09-02

(Press-News.org) About The Study: At the lesion level, very intensive lipid-lowering therapy induced substantially greater percent atheroma volume regression than described in previous vessel-level analyses. Compared with statin therapy alone, alirocumab treatment was associated with greater enlargement of the lesion minimum lumen area and more frequent transition of presumably high-risk plaque phenotypes into more stable, less lipid-rich plaque phenotypes.

Corresponding Author: To contact the corresponding author, Lorenz Raber, MD, PhD, email lorenz.raeber@insel.ch.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamacardio.2024.3200)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.

# # #

Media advisory: This study is being presented at the European Society of Cardiology Congress 2024.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2024.3200?guestAccessKey=1508c832-690b-4b0d-9d00-2a20c1e533dc&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=090224

END

ELSE PRESS RELEASES FROM THIS DATE:

How cells control gene expression by cleaning up their mistakes

2024-09-02

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism increases the diversity of proteins that can be generated from genes, by assembling sections of genetic code into different combinations. This is believed to enhance biological complexity by allowing genes to produce different versions of proteins, or protein isoforms, for many different uses. New research from the University of Chicago suggests that alternative splicing may have an even greater influence on biology than just by creating new protein isoforms. The ...

Global South cities lack cooling green spaces

2024-09-02

Cities in the Global South are more exposed to extreme heat because they lack cooling green spaces, new research shows. The study found that Global South cities have just 70% of the “cooling capacity” provided by urban greenery in the Global North. With temperatures rising, combined with the “urban heat island” effects that make cities hotter than rural areas, heat-related illness and death in cities are becoming more common. Urban green spaces can help reduce this risk, cooling down outdoor environments and providing vital refuges. The research – led by an international team including Nanjing, Exeter, Aarhus and North Carolina State universities – ...

The risk of global water scarcity is greater when accounting for the origin of rain.

2024-09-02

Securing the world's water supply is one of the greatest challenges of our time. Research at Stockholm University is now presenting an alternative method for quantifying the global risk of water scarcity. Results indicate higher risks to water supply than previously expected if accounting for the environmental conditions and governability where rain is produced. The common idea of global water supply is rain falling on the earth's surface and then stored in aquifers, lakes, and rivers. This idea is usually used to assess water security and the risk of water scarcity. However, a new study published in Nature Water shows how the water risks are dependent on governance ...

New pharmaceutically active substances from billions of newly combined molecules

2024-09-02

Nowadays, there’s lots of buzz about spectacular new medical treatments such as personalised cancer therapy with modified immune cells or antibodies. Such treatments, however, are very complex and expensive and so find only limited application. Most medical therapies are still based on small chemical compounds that can be produced in large quantities and thus at low cost. Billions of new molecules in just a few weeks The bottleneck in the development of new molecular therapies is the limited number of new active ...

The dark side of egg donation: racial discrimination in fees and unspoken health risks

2024-09-02

White women are paid up to eight times more for their eggs than Black women in the US, according to data uncovered by the author of a new book which exposes the lesser-known ramifications of egg donation. Eggonomics by Diane M. Tober reveals statistics and stories which illuminate the rarely-told, complex realities of egg donation, and airs personal accounts of disturbing power imbalances within the industry. She takes a microscope to the industry across the globe, but in particular in the U.S. and Spain. Donor disparities Tober finds ...

Wearable heart monitor increases diagnosis of irregular heart rhythm

2024-09-01

DURHAM, N.C. – Wearable, long-term continuous heart monitors helped identify 52% more cases of atrial fibrillation compared to usual care, but that did not lead to a reduction in hospitalizations due to stroke, according to a study led by the Duke Clinical Research Institute. The findings, reported Sept. 1 at the European Society of Cardiology meeting and published in the Journal of the American College of Cardiology, provide inconclusive data about whether atrial fibrillation screening lowers stroke rates. The COVID pandemic led to an early halt of the study before fully enrolling, so it did not ...

Singapore scientists to use exosomes secreted by living cells to successfully target TKI-resistant cancer

2024-09-01

Singapore, 2 September 2024 – In a new study, clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS) have demonstrated the use of exosomes to successfully target squamous cell cancer tumours that are usually resistant to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). Their research is the first where exosomes have been applied to target TKI-resistant cancers in Singapore. The findings were published in the journal Developmental Cell last month. Epidermal growth factor receptor, also known as EGFR, is a biomarker ...

Brigham-led clinical trial finds finerenone reduces worsening heart failure and cardiovascular death

2024-09-01

Finerenone reduced the composite of total first and recurrent heart failure (HF) events (hospitalizations for HF or urgent HF visits) and cardiovascular death in patients with HF and mildly reduced or preserved ejection fraction, according to an international clinical trial led by investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system. Heart failure events and cardiovascular death were less common in the finerenone group than in the placebo group. Overall, the rate of serious adverse events was similar across the groups, but rates of hyperkalemia—elevated levels of potassium in the blood—were higher for the ...

SGLT2 inhibitor empagliflozin is shown to be safe and effective for treating patients who have suffered a heart attack

2024-09-01

The SGLT2 inhibitor empagliflozin confers kidney-protective benefits and can therefore be given safely and effectively to patients when they are hospitalized for acute myocardial infarction (MI), a Mount Sinai-led global team of researchers has shown. The team, led by Deepak L. Bhatt, MD, MPH, MBA, Director of the Mount Sinai Fuster Heart Hospital and the Dr. Valentin Fuster Professor of Cardiovascular Medicine at the Icahn School of Medicine at Mount Sinai, performed a secondary analysis of the results from a worldwide trial known as EMPACT-MI. They also demonstrated that empagliflozin can consistently reduce heart failure events ...

Potassium supplementation and prevention of atrial fibrillation after cardiac surgery

2024-08-31

About The Study: For atrial fibrillation after cardiac surgery prophylaxis, supplementation only when serum potassium concentration fell below 3.6 mEq/L was noninferior to the current widespread practice of supplementing potassium to maintain a serum potassium concentration greater than or equal to 4.5 mEq/L. The lower threshold of supplementation was not associated with any increase in dysrhythmias or adverse clinical outcomes. Corresponding Author: To contact the corresponding author, Benjamin O’Brien, MD, PhD, email Ben.OBrien@dhzc-charite.de. To ...

LAST 30 PRESS RELEASES:

Scientists trace microplastics in fertilizer from fields to the beach

The Lancet Obstetrics, Gynecology, & Women’s Health: Taking paracetamol during pregnancy does not increase risk of autism, ADHD or intellectual disabilities, confirms new gold-standard evidence review