Psychiatric safety of semaglutide for weight management in people without known major psychopathology

JAMA Internal Medicine

2024-09-03

(Press-News.org) About The Study: The results of this post hoc analysis suggest that treatment with semaglutide, 2.4 mg, did not increase the risk of developing symptoms of depression or suicidal ideation/behavior vs placebo and was associated with a small but statistically significant reduction in depressive symptoms (not considered clinically meaningful). People with obesity should be monitored for mental health concerns so they can receive appropriate support and care.

Corresponding Author: To contact the corresponding author, Thomas A. Wadden, PhD, email wadden@pennmedicine.upenn.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamainternmed.2024.4346)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2024.4346?guestAccessKey=f3c34dad-e547-4b48-8810-a9af3ea914cb&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=090324

END

ELSE PRESS RELEASES FROM THIS DATE:

One minute to save lives: Teaming up with pediatricians to secure firearms

2024-09-03

Large study included 47,307 well-child visits at 30 clinics in Michigan and Colorado Almost 50% of clinicians receiving a prompt plus added support delivered a secure firearm storage program during well visits versus just 22% of doctors receiving prompt only Firearm-related injuries are the leading cause of death for young people in the U.S. ‘We can save lives’ with a brief program to support parents in secure storage CHICAGO --- If it takes a pediatrician less than one minute per visit to talk to parents about how to securely store their firearms and offer a free cable lock, why do only 2% of doctors report routinely doing so? Turns out, they ...

No link found between popular diabetes medication and suicide

2024-09-03

There has been concern that common diabetes drugs could increase the risk of suicide and self-harm. In a new study, led by researchers at Karolinska Institutet and published in Jama Internal Medicine, no such risk increase was observed. Drugs of the type GLP-1 analogues lower blood sugar levels and are used by millions of people worldwide. They are mainly used to treat diabetes, but drugs such as Ozempic have also been shown to be effective against obesity, which has increased their popularity. At the same time, both American and European drug authorities have warned that there may be risks associated with ...

Thousands of jellyfish clones are multiplying in B.C. lakes

2024-09-03

An invasive, freshwater jellyfish is popping up in B.C. waters in the thousands and future sightings could increase rapidly, according to UBC research. The peach blossom jellyfish clones have been spotted in 34 places in B.C., its furthest northern range in North America, and a recent paper predicts sightings and the number of locations will increase by the end of the decade as climate change extends this range. Dr. Florian Lüskow, who completed the research during his postdoctoral fellowship ...

Infertility challenges amongst endangered wild songbird population revealed in new study

2024-09-03

A new study using 10 years of data has provided the most comprehensive estimate of infertility rates to date in a threatened wild animal population Researchers from the University of Sheffield found infertility accounts for 17 per cent of hatching failure in an endangered songbird, the hihi, with the majority of hatching failure being caused by embryo death This is the first study to find a link between small population size, sex ratio bias, and reduced fertilisation rates in wild animals By considering the impacts of population size and sex ratio on fertility, conservationists can better manage the numbers and composition of animals in populations ...

Representatives from NASA, ESA, JAXA, ASI, KASA meet during COSPAR 2024 to reinforce cooperation and coordination for future missions to the asteroid Apophis

2024-09-03

Each agency representative presented the status of their current involvement in current and future planning for missions to Apophis (including extended mission for OSIRIS-REx, renamed OSIRIS-APEX, for NASA and the RAMSES mission for ESA) as well as the existing partnerships and mutual involvement in other agency’s missions, e.g. the infrared camera provided by JAXA in ESA’s mission Hera. Concepts to fly to Apophis, as well as reuse of existing payloads, spare parts and hardware, coordination of arrival time at Apophis of the different spacecraft, techniques to be demonstrated, ...

Vision-based ChatGPT shows deficits interpreting radiologic images

2024-09-03

OAK BROOK, Ill. – Researchers evaluating the performance of ChatGPT-4 Vision found that the model performed well on text-based radiology exam questions but struggled to answer image-related questions accurately. The study’s results were published today in Radiology, a journal of the Radiological Society of North America (RSNA). Chat GPT-4 Vision is the first version of the large language model that can interpret both text and images. “ChatGPT-4 has shown promise for assisting radiologists in tasks such as simplifying patient-facing radiology reports and identifying ...

Minimal ADHD risk from prenatal cannabis use new study reveals

2024-09-03

A new study reveals nuanced findings on the neuropsychiatric risks of prenatal cannabis exposure. The research found a slight increase in the risk of ADHD and a heightened vulnerability to cannabis use in offspring. These results highlight the need for continued caution and further investigation into the long-term effects of cannabis use during pregnancy. A new study led by Prof. Ilan Matok and Hely Bassalov PharmD from the Department of Clinical Pharmacy at the School of Pharmacy in the Faculty of Medicine at Hebrew University in collaboration ...

Study suggests gun-free zones do not attract mass shootings

2024-09-03

Gun-free zones have often been blamed for making schools, malls and other public areas more attractive to shooters; however, there have been no quantitative studies examining those claims. Now, in a first of its kind study published in The Lancet Regional Health Americas, researchers at UC Davis Health and other institutions have shown that gun-free zones may, in fact, reduce the risk of mass shootings. "Our most significant finding is that gun-free zones don't attract active shooters,” said the study’s first author, Paul Reeping, ...

Mathematicians model a puzzling breakdown in cooperative behaviour

2024-09-03

Darwin was puzzled by cooperation in nature—it ran directly against natural selection and the notion of survival of the fittest. But over the past decades, evolutionary mathematicians have used game theory to better understand why mutual cooperation persists when evolution should favour self-serving cheaters. At a basic level, cooperation flourishes when the costs to cooperation are low or the benefits large. When cooperation becomes too costly, it disappears—at least in the realm of pure mathematics. ...

Kessler Foundation scientists publish protocol for combining aerobic exercise and cognitive rehabilitation in multiple sclerosis

2024-09-03

East Hanover, NJ – September 3, 2024 – Researchers at Kessler Foundation have published a new clinical protocol examining the combination of aerobic exercise and cognitive rehabilitation to improve learning and memory in individuals with multiple sclerosis (MS) who have mobility disability. The article, “Rationale and methodology for examining the combination of aerobic exercise and cognitive rehabilitation on new learning and memory in persons with multiple sclerosis and mobility disability: Protocol for a randomized controlled trial,” was published online and will appear in print in Contemporary Clinical Trials, ...

Inhibition of cyclooxygenase-2 upregulates the nuclear factor erythroid 2-related factor 2 signaling pathway to mitigate hepatocyte ferroptosis in chronic liver injury

Psychiatric safety of semaglutide for weight management in people without known major psychopathology

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: