(Press-News.org) Sept. 4, 2024
WASHINGTON, D.C. – The Patient-Centered Outcomes Research Institute (PCORI) today began inviting proposals through eight new funding opportunities, including three PCORI Funding Announcements (PFAs) for patient-centered comparative clinical effectiveness research (CER). One PFA is offering up to $100 million to support CER studies promoting healthy children and youth, a demographic representing more than a third of the U.S. population and facing a range of mental and physical health challenges.
“These latest funding announcements reinforce PCORI’s role as a leader in funding patient-centered comparative clinical effectiveness research,” said PCORI Executive Director Nakela L. Cook, M.D., MPH. "PCORI-funded CER studies are designed to generate valuable insights addressing critical evidence gaps to help people make better-informed healthcare decisions and improve healthcare delivery and outcomes across all age groups."
Promoting healthy children and youth is one of PCORI’s Research Project Agenda Topic Themes, which address health issues impacting millions of people living in the United States. The Promoting Healthy Children and Youth PFA seeks to fund studies focused on interventions that improve patient-centered outcomes among children and youth ages 0-24. The PFA is open broadly to CER questions that address the health of children and youth; however, PCORI is particularly interested in proposals on:
Preventing and treating pediatric obesity.
Addressing social determinants of health and social needs to improve health outcomes.
Preventing substance abuse through identified risk factors.
PCORI also is offering up to $200 million through the Phased Large Awards for Comparative Clinical Effectiveness Research (PLACER) PFA, for ambitious, large-scale two-phased trials addressing critical decisional dilemmas requiring new evidence about the comparative effectiveness of available interventions. Additionally, up to $160 million is available through the Broad Pragmatic Studies (BPS) PFA, for smaller-scale CER studies and includes special areas of emphasis on:
Social isolation in older adults.
Health communication strategies for COVID-19 vaccine uptake.
Sleep health in inpatient settings.
Through the PLACER and BPS PFAs, research teams may submit applications on any patient-centered CER topic that advances progress on PCORI’s National Priorities for Health. The BPS PFA also invites studies using PCORnet®, the National Patient-Centered Clinical Research Network, for large-scale research.
Additional PFAs focus on evidence uptake, the science of engagement and methods
PCORI supports initiatives to accelerate the adoption of useful CER evidence into clinical practice. Three PFAs seek proposals for projects to implement results of PCORI-funded research and advance shared decision-making approaches in practice settings.
Offering up to $36 million, the Science of Engagement PFA seeks proposals for studies to build evidence on optimizing engagement of patients and other healthcare decision makers in patient-centered CER design and conduct.
Another PFA, offering up to $12 million, seeks proposals for methods development studies to enhance methodological approaches across the patient-centered CER field.
“These funding activities support PCORI’s mission by enhancing the knowledge and resources needed to conduct stakeholder-engaged and rigorous patient-centered comparative clinical effectiveness research,” said Harv Feldman, M.D., MSCE, PCORI’s deputy executive director for patient-centered research programs. “We look forward to valuable evidence and enhanced methodologies to support the conduct of patient-centered CER that will emerge through these new PCORI Funding Announcements.”
Awarded funding totals within and across PCORI PFAs are subject to the quantity and quality of applications received. To date, PCORI has awarded more than $4.5 billion to fund patient-centered CER and research-related projects. Details about recent funding announcements are available on PCORI’s website.
About PCORI
The Patient-Centered Outcomes Research Institute (PCORI) is the nation’s leading funder of patient-centered comparative clinical effectiveness research (CER). By comparing two or more health or healthcare approaches, CER generates evidence that helps people make better-informed decisions and improves healthcare delivery and outcomes. PCORI takes a holistic approach to its work, ensuring that patients and other health decision makers are engaged as partners throughout the research process, supporting dissemination and implementation of results in practice and strengthening clinical research infrastructure to advance patient-centered CER. PCORI is an independent, non-profit organization authorized by Congress. Visit pcori.org.
END
PCORI offers up to $100 million for new research promoting healthy children and youth
New funding opportunities seek proposals for patient-centered CER addressing an array of health concerns across all age groups
2024-09-04
ELSE PRESS RELEASES FROM THIS DATE:
Newly discovered gene may influence longevity
2024-09-04
It turns out that a particular gene has a great influence on longevity, a new study from the University of Copenhagen concludes. This may pave the way for new treatment.
Sleep, fasting, exercise, green porridge, black coffee, a healthy social life …
There is an abundance of advice out there on how to live a good, long life. Researchers are working hard to determine why some people live longer than others, and how we get the most out of our increasingly long lives.
Now researchers from the Center for Healthy Aging, Department of Cellular and Molecular Medicine at the University of Copenhagen have made a breakthrough. They have discovered that ...
SwRI signs MOU with Blade Energy Partners to support carbon dioxide sequestration research
2024-09-04
SAN ANTONIO — September 4, 2024 — Southwest Research Institute has signed a memorandum of understanding (MOU) with Blade Energy Partners, establishing a new research collaboration focused on advancing carbon dioxide storage technology to reduce greenhouse gas emissions.
Carbon capture, utilization, and storage (CCUS) refers to the practices of capturing CO2 from its industrial sources or the atmosphere, transport it using pipelines and other means, using it as alternative fuel or other industrial applications, and storing it for later use. The drive to meet net-zero greenhouse gas emissions goals and ...
Integrated design and fabrication of pneumatic soft robot actuators in a single casting step
2024-09-04
A research paper by scientists at University of Coimbra proposed an integrated approach targeting the design and fabrication of pneumatic soft actuators in a single casting step. Molds and sacrificial water-soluble hollow cores are printed using fused filament fabrication.
The new research paper, published on Jul. 17 in the journal Cyborg and Bionic Systems, presented an integrated process for the design and fabrication of soft robot actuators in a single casting. The author proved the availability, versatility, and effectiveness of the proposed methods, contributing to accelerating the design and fabrication of soft robots.
Bio-inspired soft robots have already shown the ability to handle ...
Underwater resection of neuroendocrine tumors of the gastrointestinal tract
2024-09-04
Neuroendocrine tumors (NETs) of the gastrointestinal (GI) tract are a rare and heterogeneous group of malignancies arising from the neuroendocrine cell system. These tumors are more commonly encountered in the stomach, appendix, small bowel, rectum, and pancreas. Over the past few decades, the incidence of GI NETs has increased due to improved diagnostic capabilities and an aging population. The management of these tumors requires a careful assessment of various factors, including the site, size, grading, depth of invasion, and local lymphadenopathy, as they significantly impact prognosis and treatment ...
Microglial responses to hypernatremia: new insights into brain health
2024-09-04
Microglia are the brain’s immune cells known to play a vital role in maintaining neural function and responding to potential threats. However, when the brain is subjected to hyperosmotic stress—a condition characterized by elevated extracellular sodium levels, the microglial response can become exaggerated, leading to potentially harmful effects. Understanding the mechanisms behind this heightened response is crucial for the treatment of hypernatremia-induced neurological dysfunctions.
To ...
Breaking the link between obesity and atrial fibrillation with a new cellular target
2024-09-04
A cellular link between obesity and atrial fibrillation — a heart condition that afflicts over 33 million people worldwide — presents a promising target for new therapies, researchers from the University of Illinois Chicago report.
Obesity is among the leading causes of atrial fibrillation, an irregular heart rhythm that can lead to heart failure and stroke. But scientists still don’t know how high levels of body fat cause this heart condition.
In a new study published in The Journal of Clinical Investigation, UIC researchers identified a cellular pathway essential to obesity-induced ...
New research has potential to speed up forensic analysis in sexual assault cases
2024-09-04
A team of researchers has developed a radical new technique for analyzing evidence in sexual assault cases. The new approach could streamline the forensics pipeline and reduce delays in the processing of DNA evidence.
The research is described in a paper published today in the journal Advanced Science.
There are almost half a million sexual assaults in Canada every year with many more going unreported. The new approach could mitigate one of the reasons victims are reluctant to report assaults: the perception that ...
Banning friendships can backfire: moms who ‘meddle’ make bad behavior worse
2024-09-04
Delinquent activities almost always occur outside of the home and away from adult supervision, so it is only natural for parents to blame peers for their child’s bad behavior. Not surprisingly, many parents also assume that they can prevent future problems by limiting contact with suspicious peers.
However, a new study cautions parents – especially meddling moms – to resist the temptation to prohibit friendships because doing so only makes a bad situation worse. How can this be?
Results from a new longitudinal study of middle school youth, published in The Journal of Child Psychology and Psychiatry, indicates that maternal disapproval of friends in ...
AIM-HI Accelerator Fund announces the 2024 Women’s Venture Competition winners
2024-09-04
ROCKVILLE, MD (September 4, 2024) The AIM-HI Accelerator Fund is pleased to announce that the 2024 Women’s Venture Competition’s first prize winner with distinction goes to HDAX Therapeutics led by its CEO and Co-Founder, Nabanita Nawar, Ph.D, and the Second Prize Winner goes to ARMA BIO, led by Co-Founder & CSO, Paraskevi Giannakakou, Ph.D.
The 2024 AIM-HI Women’s Venture Competition Committee reviewed more than 50 applications from 10 countries, including Canada, Ghana, India, Israel, Norway, Romania, Singapore, Spain, Thailand, ...
Scientists use magnetic nanotech to safely rewarm frozen tissues for transplant
2024-09-04
Every day, people die waiting for an organ transplant. Time is at a premium, not just for those awaiting organs, but also for the organs themselves, which can deteriorate rapidly during transportation. Looking to extend the viability of human tissues, researchers report in ACS’ Nano Letters their efforts to facilitate completely freezing, rather than cooling and then thawing, potentially life-saving organs. They demonstrate a magnetic nanoparticle’s successful rewarming of animal tissues.
As of August 2024, more than 114,000 people are on the U.S. national transplant ...
LAST 30 PRESS RELEASES:
Study links wind-blown dust from receding Salton Sea to reduced lung function in area children
Multidisciplinary study finds estrogen could aid in therapies for progressive multiple sclerosis
Final day of scientific sessions reveals critical insights for clinical practice at AAO-HNSF Annual Meeting and OTO EXPO
Social adversity and triple-negative breast cancer incidence among black women
Rapid vs standard induction to injectable extended-release buprenorphine
Galvanizing blood vessel cells to expand for organ transplantation
Common hospice medications linked to higher risk of death in people with dementia
SNU researchers develop innovative heating and cooling technology using ‘a single material’ to stay cool in summer and warm in winter without electricity
SNU researchers outline a roadmap for next-generation 2D semiconductor 'gate stack' technology
The fundamental traditional Chinese medicine constitution theory serves as a crucial basis for the development and application of food and medicine homology products
Outfoxed: New research reveals Australia’s rapid red fox invasion
SwRI’s Dr. Chris Thomas named AIAA Associate Fellow
National Collegiate Athletic Association (NCAA) funding for research on academic advising experiences of Division I Black/African American student-athletes at minority serving institutions
Johri developing artificial intelligence literacy among undergraduate engineering and technology students
Boston Children’s receives a $35 million donation to accelerate development of therapeutic options for children with brain disorders through the Rosamund Stone Zander and Hansjoerg Wyss Translational
Quantum crystals offer a blueprint for the future of computing and chemistry
Looking beyond speech recognition to evaluate cochlear implants
Tracking infectious disease spread via commuting pattern data
Underweight children cost the NHS as much per child as children with obesity, Oxford study finds.
Wetland plant-fungus combo cleans up ‘forever chemicals’ in a pilot study
Traditional Chinese medicine combined with peginterferon α-2b in chronic hepatitis B
APS and SPR honor Dr. Wendy K. Chung with the 2026 Mary Ellen Avery Neonatal Research Award
The Gabriella Miller Kids First Data Resource Center (Kids First DRC) has launched the Variant Workbench
Yeast survives Martian conditions
Calcium could be key to solving stability issues in sodium-ion batteries
Can smoother surfaces prevent hydrogen embrittlement?
Heart rate changes predict depression treatment success with magnetic brain stimulation
Genetics pioneer transforms global depression research through multi-omics discoveries
MDMA psychiatric applications synthesized: Comprehensive review examines PTSD treatment and emerging therapeutic indications
Psychedelics offer new therapeutic framework for stress-related psychiatric disorders
[Press-News.org] PCORI offers up to $100 million for new research promoting healthy children and youthNew funding opportunities seek proposals for patient-centered CER addressing an array of health concerns across all age groups