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Carnegie Mellon to lead development of implantable cell-based bioelectronic devices for patient-specific treatment and disease monitoring

Carnegie Mellon to lead development of implantable cell-based bioelectronic devices for patient-specific treatment and disease monitoring
2024-10-02
(Press-News.org) PITTSBURGH – A Carnegie Mellon University-led team has secured an award of up to $42 million from the Advanced Research Projects Agency for Health (ARPA-H) to accelerate the development of implantable, cell-based bioelectronic devices that deliver patient-specific therapy and monitor disease status, for conditions like hypo- and hyperthyroidism, in real time. This award is part of the ARPA-H REACT program, which supports the advancement of implantable bioelectronic devices to improve patient management of chronic diseases.

Burak Ozdoganlar, professor of mechanical engineering at Carnegie Mellon University, will head the Biointegrated Implantable Systems for Cell-based Sensing and Therapy (BIO-INSYNC) project as the primary investigator. This effort is part of the ongoing Bioelectric Medicine Initiative at Carnegie Mellon University. In addition to Carnegie Mellon researchers, the multidisciplinary project team includes members from the University of Pittsburgh/UPMC, University of Florida, and University of California—Santa Cruz. Two companies, Ginkgo Bioworks and Velentium, are also integral parts of the consortium.

During the six-year project term, the team will develop and test two multi-part, pacemaker-sized system platforms that will be implanted in a patient's chest cavity through an outpatient procedure and offer real-time, adjustable, low-cost therapy and disease monitoring for up to 12 months. Following a “living pharmacy” concept, one of the systems will use human cells to produce and release the necessary dose of a hormone or other therapeutic molecules on demand. Utilizing a “living sentinel” concept, the second system will use cells that measure critical biomarkers to monitor the patient’s disease status continuously in real time. Both will feature remote interfaces to communicate key information and measurements with the patient via smart devices or directly to their healthcare provider.

While this technology can be used to treat various diseases and conditions, the collaborative team will specifically focus on its application to thyroid disorders, which impact an estimated 12% of Americans, including children and adults. BIO-INSYNC devices will provide a significant advantage to patients who will be able to continuously monitor key hormones and deliver the right therapeutic dose as needed, eliminating current management protocols like daily medications and regular blood testing. Notably, the project will conduct a first-in-human clinical trial for patients facing thyroid conditions.

“The thyroid gland controls so many integral processes within the body, and thyroid hormone imbalances can lead to weight gain or loss, mental health issues, fertility problems, and even heart diseases,” explained Ozdoganlar. “It’s important also to note that thyroid disorders disproportionally impact vulnerable populations. Our bioelectronic system offers an innovative avenue for patients to self-manage their thyroid hormone levels at a fraction of the cost. The aim is to improve patients’ quality of life by improving thyroid treatments while bridging disparities in healthcare to attain equitable care for all.”

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About Carnegie Mellon University

Carnegie Mellon University is a private, internationally ranked research university with acclaimed programs spanning the sciences, engineering, technology, business, public policy, humanities, and the arts. Our diverse community of scholars, researchers, creators, and innovators is driven to make real-world impacts that benefit people across the globe. With a bold, interdisciplinary, and entrepreneurial approach, we do the work that matters.

About the College of Engineering

The College of Engineering at Carnegie Mellon University is a top-ranked engineering college that is known for our Advanced Collaboration culture in research and education. The College is well-known for working on problems of both scientific and practical importance. Our “maker” culture is ingrained in all that we do, leading to novel approaches and transformative results. Our acclaimed faculty have a focus on innovation management and engineering to yield transformative results that will drive the intellectual and economic vitality of our community, nation, and world.

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Carnegie Mellon to lead development of implantable cell-based bioelectronic devices for patient-specific treatment and disease monitoring

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[Press-News.org] Carnegie Mellon to lead development of implantable cell-based bioelectronic devices for patient-specific treatment and disease monitoring