(Press-News.org) Heart failure is a rapidly growing public health issue that can be difficult to manage on a global scale. But there are tools that exist that can improve outcomes, such as guideline-directed medical therapy (GDMT). New UCLA-led research highlights the important role that these guidelines can play in reducing mortality rates for individuals suffering from heart failure with reduced ejection fraction (HFrEF), a type of heart failure affecting an estimated 29 million people worldwide.
“These guidelines are being significantly underutilized in clinical settings globally and there are barriers that contribute to this, including poor health literacy, limited access to care and medication costs,” said Dr. Amber Tang, the lead author of the study and a medical resident at UCLA.
The study, published in JAMA Cardiology, found that of the estimated 29 million people worldwide with HFrEF, many who were eligible to receive life-saving treatment did not receive treatment (8.2 million individuals for beta blocker treatment;20.4 million individuals for angiotensin receptor neprilysin inhibitors treatment;12.2 million individuals for mineralocorticoid receptor antagonists treatment; and 21.2 million for SGLT2 inhibitors treatment), demonstrating the challenge in implementing these global guidelines.
However, with optimal implementation, researchers predict that the use of GDMT could prevent 1.2 million deaths per year worldwide, with more than one million lives saved in the Eastern Mediterranean, Southeast Asia and Western Pacific.
The study, which examined existing patient data published from large registries to estimate heart failure prevalence, GDMT eligibility, current prescription rates, and potential lives saved across the world, is the first to estimate the mortality benefit of individuals with HFrEF globally, rather than just in the United States.
“There are significant regional disparities that exist across the world, and this study draws attention to the fact that heart failure is not a monolithic entity, but a condition that varies greatly based on socioeconomic and cultural nuances,” said Dr. Gregg Fonarow, senior author of the study and director of the Ahmanson-UCLA Cardiomyopathy Center and co-director of UCLA’s Preventative Cardiology Program.
Researchers say these findings highlight the significance of heart failure as a global health issue. “To see calculated projections of the potential number of lives saved each year allows the public and the medical community to see the magnitude of the problem and the urgency needed to bring therapeutic interventions to people around the world.”
END
Global study highlights the life-saving impact of Guideline-Directed Medical Therapy (GDMT) in heart failure patients
UCLA researchers predict following standard clinical guidelines can prevent 1.2 million deaths from heart failure worldwide
2024-10-02
ELSE PRESS RELEASES FROM THIS DATE:
New method quantifies single-cell data’s risk of private information leakage
2024-10-02
Access to publicly available human single-cell gene expression datasets, or scRNA-seq datasets, has significantly enhanced researchers’ understanding of both complex biological systems and the etymology of various diseases. However, the increase in accessibility raises a greater concern about the privacy of the individuals who donated the cells and the likelihood of their private health details being shared without consent.
Previous studies on these privacy breaches have focused on bulk gene expression data sharing, where the average expression levels of genes are measured across a large population of cells from a tissue or sample rather than an individual cell. Because single-cell ...
Eyes on the fries: how our vision creates a food trend
2024-10-02
KEY POINTS
Human judgement of food images is influenced by judgements that precede it
Experiment tested reactions of more than 600 people making food choices
Highly relevant given widespread use of Uber Eats or phone-based menus
Finding could assist treatments for eating disorders or assist with food marketing
Research at the University of Sydney has revealed that we don’t judge food simply on its merits but are influenced by what we have seen beforehand, a cascading phenomenon known as ‘serial dependence’.
The research, published today in the high-impact journal Current Biology, was conducted by Professors David Alais ...
UVM scientist maps fruit fly brain
2024-10-02
A team of scientists supported by the National Institutes of Health (NIH)’s The BRAIN Initiative®, including Davi Bock, Ph.D., Associate Professor of Neurological Sciences at UVM’s Robert Larner, M.D. College of Medicine, recently made a substantial advancement in neurobiological research by successfully mapping the entire brain of Drosophila melanogaster, more commonly known as the fruit fly.
The study, titled “Whole-brain annotation and multi-connectome cell typing of Drosophila,” recently published ...
Bridging the gap: how pragmatic trials can better serve healthcare systems
2024-10-02
Boston, MA – A new thought piece led by the Harvard Pilgrim Health Care Institute with collaborators from Duke University and Kaiser Permanente Washington Health Research Institute highlights the challenges facing healthcare researchers and decision makers in the quest to improve population health in a constantly evolving healthcare landscape. The authors offer strategies to enhance the effectiveness of pragmatic clinical trials and increase their impact on real-world healthcare settings.
The Viewpoint appears October 2 in JAMA.
Pragmatic clinical trials, designed to inform health ...
UChicago scientists decode key mutation in many cancers
2024-10-02
Inside every cell, inside every nucleus, your continued existence depends on an incredibly complicated dance. Proteins are constantly wrapping and unwrapping DNA, and even minor missteps can lead to cancer.
A new study from the University of Chicago reveals a previously unknown part of this dance—one with significant implications for human health.
In the study, published Oct. 2 in Nature, a team of scientists led by UChicago Prof. Chuan He, in collaboration with University of Texas Health Science Center at ...
NYU Langone awarded $1.6 million to investigate Alzheimer’s & Parkinson’s progression through the eye
2024-10-02
Researchers at NYU Langone Health were awarded $1.6 million from the National Institutes of Health (NIH) to investigate changes in the eye that may indicate early signs of Alzheimer’s disease and Parkinson’s disease.
The award, OT2OD038130, recognizes the eye as a part of the brain and its role as a window into cognitive and visual health. After the initial $1.6 million award, the grant may renew an additional two years, for a total of $4.8 million as part of the NIH Common Fund Venture Program’s new Oculomics Initiative. Oculomics is a relatively new term to describe the integrative use of technology and ...
Missing link found in gamma emission phenomena from thunderclouds
2024-10-02
Groundbreaking Discoveries in Gamma-Ray Emissions from Thunderstorms
In the recent edition of Nature, groundbreaking results about the gamma-ray emissions produced during thunderstorms are presented. Overall, these findings reveal that gamma-ray emission from thunderclouds is much more complex, diverse, and dynamic than previously thought. Understanding these phenomena is crucial to uncovering the secrets of lightning.
Flickering Gamma-Ray Flashes: A New Discovery
Entitled “Flickering Gamma-Ray Flashes, the Missing Link between Gamma Glows and TGFs,” the paper by Østgaard et al. [2024] reports unique observations of a new phenomenon called Flickering Gamma-Ray ...
Social media users’ actions, rather than biased policies, could drive differences in platform enforcement
2024-10-02
A new paper, “Differences in misinformation sharing can lead to politically asymmetric sanctions,” published today in Nature suggests that the higher quantity of social media policy enforcement (such as account suspensions) for conservative users could be explained by the higher quantity of misinformation shared by those conservative users — and so does not constitute evidence of inherent biases in the policies from social media companies or in the definition of what constitutes misinformation.
Written by ...
How a bacterium becomes a permanent resident in a fungus
2024-10-02
Endosymbiosis is a fascinating biological phenomenon in which an organism lives inside another. Such an unusual relationship is often beneficial for both parties. Even in our bodies, we find remnants of such cohabitation: mitochondria, the powerhouses of our cells, evolved from an ancient endosymbiosis. Long ago, bacteria entered other cells and stayed. This coexistence laid the foundation for mitochondria and thus the cells of plants, animals, and fungi.
What is still poorly understood, however, is how an endosymbiosis as a lifestyle actually arises. A bacterium that more or less accidentally ...
Study: For long COVID, lithium aspartate at low doses is ineffective, but higher doses may be promising
2024-10-02
BUFFALO, N.Y. — A small University at Buffalo clinical trial has found that at low doses, lithium aspartate is ineffective in treating the fatigue and brain fog that is often a persistent feature of long COVID; however, a supplemental dose-finding study found some evidence that higher doses may be effective.
Published in JAMA Network Open on Oct. 2, the study was led by Thomas J. Guttuso, Jr., MD, professor of neurology in the Jacobs School of Medicine and Biomedical Sciences at UB and a physician with UBMD Neurology.
“It’s a negative study with a positive twist,” Guttuso concludes.
Because ...
LAST 30 PRESS RELEASES:
ASU researchers to lead AAAS panel on water insecurity in the United States
ASU professor Anne Stone to present at AAAS Conference in Phoenix on ancient origins of modern disease
Proposals for exploring viruses and skin as the next experimental quantum frontiers share US$30,000 science award
ASU researchers showcase scalable tech solutions for older adults living alone with cognitive decline at AAAS 2026
Scientists identify smooth regional trends in fruit fly survival strategies
Antipathy toward snakes? Your parents likely talked you into that at an early age
Sylvester Cancer Tip Sheet for Feb. 2026
Online exposure to medical misinformation concentrated among older adults
Telehealth improves access to genetic services for adult survivors of childhood cancers
Outdated mortality benchmarks risk missing early signs of famine and delay recognizing mass starvation
Newly discovered bacterium converts carbon dioxide into chemicals using electricity
Flipping and reversing mini-proteins could improve disease treatment
Scientists reveal major hidden source of atmospheric nitrogen pollution in fragile lake basin
Biochar emerges as a powerful tool for soil carbon neutrality and climate mitigation
Tiny cell messengers show big promise for safer protein and gene delivery
AMS releases statement regarding the decision to rescind EPA’s 2009 Endangerment Finding
Parents’ alcohol and drug use influences their children’s consumption, research shows
Modular assembly of chiral nitrogen-bridged rings achieved by palladium-catalyzed diastereoselective and enantioselective cascade cyclization reactions
Promoting civic engagement
AMS Science Preview: Hurricane slowdown, school snow days
Deforestation in the Amazon raises the surface temperature by 3 °C during the dry season
Model more accurately maps the impact of frost on corn crops
How did humans develop sharp vision? Lab-grown retinas show likely answer
Sour grapes? Taste, experience of sour foods depends on individual consumer
At AAAS, professor Krystal Tsosie argues the future of science must be Indigenous-led
From the lab to the living room: Decoding Parkinson’s patients movements in the real world
Research advances in porous materials, as highlighted in the 2025 Nobel Prize in Chemistry
Sally C. Morton, executive vice president of ASU Knowledge Enterprise, presents a bold and practical framework for moving research from discovery to real-world impact
Biochemical parameters in patients with diabetic nephropathy versus individuals with diabetes alone, non-diabetic nephropathy, and healthy controls
Muscular strength and mortality in women ages 63 to 99
[Press-News.org] Global study highlights the life-saving impact of Guideline-Directed Medical Therapy (GDMT) in heart failure patientsUCLA researchers predict following standard clinical guidelines can prevent 1.2 million deaths from heart failure worldwide