**HLA-DRB1*01:03 and severe ulcerative colitis**

JAMA

2024-10-15

(Press-News.org) About The Study: Among individuals with ulcerative colitis, the allele HLA-DRB1*01:03 was associated with severe ulcerative colitis requiring major operation, hospitalization, and systemic corticosteroid use compared with less severe disease. HLA-DRB1*01:03 has previously been linked to ulcerative colitis incidence. This study supports earlier, targeted genetic studies comparing patients with healthy controls reporting an association with total disease and severe disease requiring colectomy.

Corresponding Author: To contact the corresponding author, Marie Vibeke Vestergaard, MSc, email marievv@dcm.aau.dk.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2024.20429)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Media advisory: This study is being presented at United European Gastroenterology Week 2024.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.20429?guestAccessKey=71e1d319-4c1e-494d-abaf-d17a65070d52&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=101524

END

ELSE PRESS RELEASES FROM THIS DATE:

Quantum leap in suicide prevention: Professor Philippe Courtet's visionary approach unveiled in Genomic Press Interview

2024-10-15

Montpellier, France – 15 October 2024. In a captivating Genomic Press Interview published on October 15, 2024, in the peer-reviewed journal Genomic Psychiatry (Genomic Press), Professor Philippe Courtet shares groundbreaking perspectives on suicide prevention and mental health care. As an influential PU-PH (Professeur des Universités-Praticien Hospitalier), he is a Professor of Psychiatry at the University of Montpellier, France, and head of emergency psychiatry at the University Hospital of, Professor Courtet stands at the forefront of ...

Need for streamlined miscarriage care in Canada

2024-10-15

Miscarriage, or early pregnancy loss, can have devastating emotional effects, but it is poorly managed in Canada. A review published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.231489 provides guidance to physicians on how to diagnose and manage this condition and calls for referral to outpatient early pregnancy assessment clinics (EPACs) as well as a compassionate approach. October 15 is Pregnancy and Infant Loss Remembrance Day. Data suggest that 15%–20% of all confirmed pregnancies result in miscarriage, with ...

Traces of ancient immigration patterns to Japan found in 2000-year-old genome

2024-10-15

A joint research group led by Jonghyun Kim and Jun Ohashi of the University of Tokyo has demonstrated that the majority of immigration to the Japanese Archipelago in the Yayoi and Kofun periods (between 3000 BCE and 538 CE) came from the Korean Peninsula. The researchers analyzed the complete genome of a “Yayoi” individual and found that, among the non-Japanese populations, the results bore the most similarity to Korean populations. Although it is widely accepted that modern Japanese populations have a dual ancestry, the discovery provides insight into the details of immigration patterns to the ...

Countries that choose to do so can reduce premature death by half, researchers say

2024-10-14

DURHAM, N.C. -- Since 1970, 37 countries have cut the probability of their citizens dying before they reach age 70 in half, a milestone that signals the remarkable progress many countries have made in preventing and treating disease. But a new report argues that this goal isn’t out of reach for any country that chooses to cut its premature mortality, even those afflicted by war or poverty. The report, published Oct. 14 by The Lancet Commission on Investing in Health, lays out a roadmap for every nation that chooses to do so to cut ...

50 by 50—How can we reduce the probability of dying before age 70 by 50% globally by 2050?

2024-10-14

A team of 50 leading international experts, the Lancet Commission on Investing in Health (CIH), explored this question, resulting in clear, actionable, and achievable measures for achieving this ambitious goal worldwide. Six of the 50 commission members are affiliated with the Bergen Centre for Ethics and Priority Setting in Health (BCEPS), a Norwegian Centre of Excellence based at the University of Bergen, Norway, including BCEPS Director and Professor Ole Frithjof Norheim, BCEPS PhD Research Fellow Sarah Bolongaita, and BCEPS-affiliated researchers Angela Chang (University ...

Research explains why some cyclists don’t wear helmets and what might convince them to wear one

2024-10-14

Copenhagen, Denmark: Wearing a helmet can prevent brain injury and deaths in cyclists, yet many do not wear a helmet. New research presented at the European Emergency Medicine Congress today (Tuesday) suggests that this is largely due to issues of convenience and comfort. [1] The study also suggests that more adult cyclists would wear helmets if they were encouraged and incentivised to do so, for example if they were provided with a free helmet, education, and periodic reminders. The research was presented by Dr Steven Friedman, an emergency doctor at Toronto General Hospital and associate professor at the University ...

Half of all patients with sepsis die within two years

2024-10-14

Copenhagen, Denmark: Half of all patients with sepsis admitted to an emergency medical department died within two years, according to Danish researchers investigating factors that could predict outcomes for these patients. Dr Finn E. Nielsen, a senior scientist in the Department of Clinical Epidemiology at Aarhus University Hospital, Denmark, told the European Emergency Medicine Congress today (Tuesday) [1] that he and his colleagues examined deaths over a long follow-up period in a prospective study of 714 adult patients admitted to the emergency department with sepsis. Their findings ...

Native Hawaiian and Pacific Islander adults have third highest cardiovascular death rate in the U.S.

2024-10-14

Embargoed for release until 5:00 p.m. ET on Monday 14 October 2024    @Annalsofim Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent. ...

Gene therapy automatically converts omega-6 to omega-3 fatty acids in the body

2024-10-14

St. Louis, MO (October 14, 2024) According to the Centers for Disease Control, nearly 20% of children and teens are considered obese. Research shows it can have a dramatic impact on a variety of health conditions, including arthritis, heart conditions and other metabolic problems, and the American Academy of Pediatrics now recommends early and intensive treatment to combat obesity. Over the last four years, Shriners Children’s St. Louis researchers have been working to develop a new way to prevent the effects of childhood obesity. Using gene therapy, Shriners Children’s St. Louis Director of Research Dr. Farshid Guilak and Senior Scientist Dr. Ruhang Tang ...

Mpox clinical presentation, diagnostic approaches, and treatment strategies

2024-10-14

About The Study: Mpox is a viral infection transmitted primarily through close skin to skin contact that typically causes a self-resolving illness but can result in severe illness and death in immunocompromised individuals. First-line therapy is supportive care, although patients with severe mpox infection may be treated with advanced therapeutics. Mpox vaccination is effective and, if available, should be offered to individuals at risk of exposure to mpox. Corresponding Author: To contact the corresponding author, Jason Zucker, MD, MS, email Jz2700@cumc.columbia.edu. To access the embargoed study: Visit our For The Media ...

LAST 30 PRESS RELEASES:

Hotter temps trigger wetlands to emit more methane as microbes struggle to keep up

ATP prevents harmful aggregation of proteins associated with Parkinson’s and ALS

Water quality could be degraded by development and conversion of forests upstream, with sediment levels and nitrogen concentrations also worsened, per modelling analysis of the Middle Chattahoochee wa

Latest ACS cancer prevention and early detection report: Smoking rates continue historic drop, but cervical cancer prevention is lagging

[Press-News.org] HLA-DRB1*01:03 and severe ulcerative colitis
JAMA