Next-gen cell-penetrating antibodies for tumor targeting and RAD51 inhibition
“Overall, the data presented in this study affirm that humanizing 3E10 preserves its crucial biological properties essential for therapeutic efficacy.”
2024-10-21
(Press-News.org)
“Overall, the data presented in this study affirm that humanizing 3E10 preserves its crucial biological properties essential for therapeutic efficacy.”
BUFFALO, NY- October 21, 2024 – A new research paper was published in Oncotarget's Volume 15 on October 1, 2024, entitled, “Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition.”
As highlighted in the abstract, monoclonal antibody therapies for cancer have shown extraordinary clinical success in recent years. However, these strategies are primarily limited to targeting specific cell surface antigens, despite many disease targets being located intracellularly.
In their paper, researchers Madison Rackear, Elias Quijano, Zaira Ianniello, Daniel A. Colón-Ríos, Adam Krysztofiak, Rashed Abdullah, Yanfeng Liu, Faye A. Rogers, Dale L. Ludwig, Rohini Dwivedi, Franziska Bleichert, and Peter M. Glazer from the Departments of Therapeutic Radiology and Genetics at Yale University School of Medicine, Gennao Bio, and the Department of Molecular Biophysics and Biochemistry at Yale University report on the humanization of the full-length, nucleic acid-binding monoclonal lupus-derived autoantibody 3E10, which exhibits a novel mechanism for cell penetration and tumor-specific targeting.
The authors compare humanized variants of 3E10 and demonstrate that cell uptake relies on the nucleoside transporter ENT2. They also find that faster cell uptake and superior in vivo tumor targeting are associated with higher affinity nucleic acid binding.
“We show that one human variant retains the ability of the parental 3E10 to bind RAD51, serving as a synthetically lethal inhibitor of homology-directed repair in vitro.”
Continue reading: DOI: https://doi.org/10.18632/oncotarget.28651
Correspondence to: Peter M. Glazer - peter.glazer@yale.edu
Keywords: cancer, 3E10, cell penetration, nucleic acid binding, nucleic acid delivery, RAD51
Click here to sign up for free Altmetric alerts about this article.
About Oncotarget:
Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).
To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media:
X
Facebook
YouTube
Instagram
LinkedIn
Pinterest
Spotify, and available wherever you listen to podcasts
Click here to subscribe to Oncotarget publication updates.
For media inquiries, please contact media@impactjournals.com.
Oncotarget Journal Office
6666 East Quaker St., Suite 1
Orchard Park, NY 14127
Phone: 1-800-922-0957 (option 2)
END
ELSE PRESS RELEASES FROM THIS DATE:
2024-10-21
Myasthenia gravis (MG) is a chronic autoimmune disorder in which antibodies block communication between nerves and muscle, resulting in weakness of the skeletal muscles. It can cause double vision, difficulty swallowing, and, occasionally, serious breathing difficulties, among other symptoms. Many autoimmune diseases such as MG, as well as a range of other human illnesses, result from the inability to regulate activity of IgG antibodies – collectively, these diseases are referred to as IgG-mediated pathologies.
In a paper out this month in Cell, researchers at Emory University have discovered a family of enzymes that ...
2024-10-21
Climate change is increasingly influencing fire behaviour worldwide and intensifying fire smoke, endangering public health from air pollution caused by fires. These are the results of two new climate change impact attribution studies, both published in Nature Climate Change, with involvement of the Potsdam Institute for Climate Impact Research PIK. The first study finds 15.8 percent higher global burned areas over the period 2003 to 2019 due to climate change, intensifying fire activity especially in Australia, South America, Western North America and Siberia. These increasing fire dynamics offset the decrease in burned area ...
2024-10-21
About The Study: The current patchwork of strategies to help patients manage high prescription drug costs highlights the structural and policy challenges within the U.S. prescription drug market that impede affordable access for some patients. While these strategies provide tangible solutions for clinicians to help patients access medically appropriate but costly medications, they do not address the root causes of high drug prices.
Corresponding Author: To contact the corresponding author, Hussain S. Lalani, MD, MPH, MSc, email hlalani@bwh.harvard.edu.
To access the embargoed study: Visit our For The Media website at this ...
2024-10-21
LOS ANGELES — Researchers from City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States, ranked among the nation’s top 5 cancer centers by U.S. News & World Report and a national leader in providing cancer patients with best-in-class, integrated supportive care programs, will present new data on integrative oncology research and clinical trials at the 21st International Conference of the Society for Integrative Oncology taking place Oct. 25 to 27.
Integrative oncology is a patient-centered ...
2024-10-21
Researchers from 15 countries, led by Amsterdam UMC, have developed a way to predict which patients are at risk of epilepsy after a cerebral venous sinus thrombosis (CVT). CVT is a type of stroke that typically affects women between the ages of 20 and 50. The prediction model is now available worldwide free of charge and research it is based on is published today in JAMA Neurology.
"We hope that as many physicians as possible will use this score to better treat and educate CVT patients across the world," says lead researcher and neurologist at Amsterdam UMC, Jonathan Coutinho.
CVT occurs when a clot blocks the veins ...
2024-10-21
About The Study: Infant mortality was higher than expected, overall and among those with congenital anomalies, for several months after the Dobbs decision in the U.S. No post-Dobbs months (i.e., no months after June 2022) showed lower than expected infant mortality. These findings are consistent with the increase in infant mortality found in Texas following the state’s abortion ban.
Corresponding Author: To contact the corresponding author, Parvati Singh, PhD, email singh.1704@osu.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamapediatrics.2024.4276)
Editor’s ...
2024-10-21
STALKING RIBOSOMES: HOW CANCER CELLS PULL POKER FACES
The protein factories of our cells are much more diverse than we thought they were. Scientists from the Netherlands Cancer Institute have now shown that cancer cells can use these so-called ribosomes to boost their invisibility cloak, helping them hide from the immune system. The team publishes their findings in Cell today. “These findings make us change how we think about ribosomes.”
Our immune system is constantly monitoring our body. In order to survive, cancer cells need to evade this ...
2024-10-21
A device that delivers direct stimulation to the brain was found to be a safe and effective means of treating depression at home, according to a new study by researchers at UTHealth Houston; the Institute of Psychiatry, Psychology & Neuroscience at King’s College London; and the University of East London.
The research was published in Nature Medicine on Oct. 21, 2024.
Transcranial direct current stimulation (tDCS) is a form of noninvasive brain stimulation that applies a weak, direct current of between 0.5 to 2 milliampere to the scalp via two electrodes. It is already commonly used in clinics to treat conditions such as psychosis ...
2024-10-21
COLUMBUS, Ohio – Expanded treatment options, increased naloxone distribution and targeted education campaigns likely led to a 37% reduction in overdose deaths from opioids combined with stimulant drugs other than cocaine, according to the results of a large federally funded study.
The finding came from a planned study of secondary outcomes of the HEALing (Helping to End Addiction Long-Term) Communities Study (HCS), which tested an intervention encompassing data-driven adoption of evidence-based practices for reducing overdose deaths in Kentucky, Massachusetts, New York and Ohio.
Death rates from specific combinations of ...
2024-10-21
Hussain S. Lalani, MD, MPH, MSc, of the Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women’s Hospital, is the lead author of a paper published in JAMA, “Strategies to Help Patients Navigate High Prescription Drug Costs.”
How would you summarize your study for a lay audience?
Prescription drugs can be expensive for patients, and many clinicians do not know how to respond when costs are too high. We reviewed the benefits and limitations of seven strategies that clinicians can use to help their patients navigate high-prescription drugs. These include co-payment cards, patient assistance ...
LAST 30 PRESS RELEASES:
[Press-News.org] Next-gen cell-penetrating antibodies for tumor targeting and RAD51 inhibition
“Overall, the data presented in this study affirm that humanizing 3E10 preserves its crucial biological properties essential for therapeutic efficacy.”
