PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Comparative metabolism of the humantenirine in liver microsomes from pigs, goats, and humans

2024-10-30
(Press-News.org) Background and objectives Gelsemium elegans Benth (G. elegans) is a traditional medicinal plant; however, it is highly toxic, and toxicity varies significantly between species. The cause of this difference has not been clarified. Humantenirine is an important toxic alkaloid in G. elegans, and its metabolism has been poorly studied. This study aimed to compare the different metabolites formed by human liver microsomes, pig liver microsomes, and goat liver microsomes.

Methods High-performance liquid chromatography/quadrupole time-of-flight mass spectrometry was used to study the metabolism of humantenirine in human liver microsomes, pig liver microsomes, and goat liver microsomes.

Results A total of eight metabolites (M1-M8) were identified, and three major metabolic pathways were found: demethylation (M1), dehydrogenation (M2, M3, M7), and oxidation (M4, M5, M6, M8).

Conclusions Based on these results, it is hypothesized that demethylation is the major detoxification pathway for humantenirine, providing important information to better understand the metabolism and toxicity differences between species of G. elegans.

 

Full text:

https://www.xiahepublishing.com/2835-6357/FIM-2024-00029

 

The study was recently published in the Future Integrative Medicine.

Future Integrative Medicine (FIM) publishes both basic and clinical research, including but not limited to randomized controlled trials, intervention studies, cohort studies, observational studies, qualitative and mixed method studies, animal studies, and systematic reviews.

 

Follow us on X: @xiahepublishing

Follow us on LinkedIn:  Xia & He Publishing Inc.

END



ELSE PRESS RELEASES FROM THIS DATE:

Some wildfire suppressants contain heavy metals and could contaminate the environment

2024-10-30
In fire-prone areas, water isn’t the only thing used to quell blazes. Wildland firefighters also apply chemical or synthetic suppressants. Researchers reporting in ACS’ Environmental Science & Technology Letters explored whether these suppressants could be a source of elevated metal levels sometimes found in waterways after wildfires are extinguished. Several products they investigated contained high levels of at least one metal, including chromium and cadmium, and could contribute to post-fire increases in the environment. “Wildfires ...

McMahon receives NIH grant to help build TTUHSC research capacity

McMahon receives NIH grant to help build TTUHSC research capacity
2024-10-30
As a leader in academic health and biomedical research training, the Texas Tech University Health Sciences Center (TTUHSC) covers the West Texas region that comprises half of the state’s land mass and is home to 10% of its population. Research at TTUHSC drives innovation and discovery, changing the lives of those it serves and attracting talented faculty, staff and students. During the latest reporting period (2020-2022), TTUHSC received an average of $12,539,679 annually in National Institutes ...

Turning silver to gold: A diacetylene derivative-based metallic luster materials

Turning silver to gold: A diacetylene derivative-based metallic luster materials
2024-10-30
Societies of the past and present have given high regard to precious metals like gold and silver. Both metals remind us of nobility and luxury. However, they are quite expensive, which restricts their applications. Therefore, materials with attractive but artificial gold- and silver-like metallic lusters are popular, finding use in jewelry, reflective materials, inks, and cosmetics.   Unfortunately, typical metallic luster materials cause environmental harm, rendering them unsustainable. Thus, scientists are actively searching for metal-free alternatives. In this direction, the research fraternity ...

Faster space communication with record-sensitive receiver

Faster space communication with record-sensitive receiver
2024-10-30
In space exploration, long-distance optical links can now be used to transmit images, films and data from space probes to Earth using light. But in order for the signals to reach all the way and not be disturbed along the way, hypersensitive receivers and noise-free amplifiers are required. Now, researchers at Chalmers University of Technology, in Sweden, have created a system that, with a silent amplifier and record-sensitive receiver, paves the way for faster and improved space communication. Space communication systems are increasingly based on optical laser beams rather than radio waves, as the signal loss has been shown to be less when light is used ...

New study shows that university students experienced increased psychological distress during COVID-19, but utilized fewer support services

New study shows that university students experienced increased psychological distress during COVID-19, but utilized fewer support services
2024-10-30
Embargoed Until 10/30/24 at 7 am PhD in Public Health candidate Elaine Russell and her mentor Kenneth Griffin, professor in the department of Global and Community Health, in George Mason University’s College of Public Health, worked with Tolulope Abidogun, also a PhD in Public Health student, and former Global and Community Health professor Lisa Lindley, now of Lehigh University, to analyze data from the American College Health Association National College Health Assessment (ACHA-NCHA III) in an effort to understand how university ...

Camera trap study reveals a “vital sanctuary” for wildlife and endangered species in Cambodia’s Central Cardamom Mountains

Camera trap study reveals a “vital sanctuary” for wildlife and endangered species in Cambodia’s Central Cardamom Mountains
2024-10-30
PHNOM PENH, Cambodia (October 30, 2024) – The first-ever camera trap study of the Central Cardamom Mountains Landscape has recorded 108 species, 23 of which are listed at risk (Vulnerable or above) on the IUCN Red List, underscoring the significance of the region as a global stronghold for biodiversity and rare and threatened species.   Editors please note: Use these links to access camera trap footage and the full report.    The report, released today by the Cambodian Ministry of Environment (MoE), the United States Agency ...

Buried Alive: Carbon dioxide release from magma deep beneath ancient volcanoes was a hidden driver of Earth’s past climate

Buried Alive: Carbon dioxide release from magma deep beneath ancient volcanoes was a hidden driver of Earth’s past climate
2024-10-30
An international team of geoscientists led by a volcanologist at Rutgers University-New Brunswick has discovered that, contrary to present scientific understanding, ancient volcanoes continued to spew carbon dioxide into the atmosphere from deep within the Earth long past their period of eruptions. In doing so, the research team has solved a long-standing mystery over what caused prolonged episodes of warming during turning points in Earth’s climate history. The work is detailed in today’s issue of the journal Nature Geoscience. “Our ...

New genetic web tool to help restore climate-resilient marine ecosystems

New genetic web tool to help restore climate-resilient marine ecosystems
2024-10-30
In the face of increased human pressures and climate change, a team of Australian scientists led by Dr Georgina Wood at Flinders University have launched a new online tool to assist marine managers and restoration experts to bolster the resilience of marine habitat-forming species. The ‘Reef Adapt’ initiative, developed by experts from the NSW Department of Primary Industries and Regional Development (NSW DPIRD), Flinders University and The University of Western Australia (UWA), aims to expand the tools available to promote diverse, adaptable and resilient ecosystems. Described in a new article in Communications Biology, Reef Adapt harnesses genetic data ...

Three pathways to achieve global climate and sustainable development goals

2024-10-30
"Sustainable development pathways are strategies that prevent dangerous climate change while at the same time moving towards a world that allows people to prosper on a healthy planet,” explains Bjoern Soergel, scientist at the Potsdam Institute for Climate Impact Research PIK and lead author of the study published in Environmental Research Letters. This is the essence of the 17 SDGs agreed by the United Nations in 2015. “Our analysis shows that all three sustainable development pathways are far more effective than our current ‘business as usual’. They drive substantial progress towards the SDGs, for example reducing the number of people in extreme poverty ...

Giant rats could soon fight illegal wildlife trade by sniffing out elephant tusk and rhino horn

Giant rats could soon fight illegal wildlife trade by sniffing out elephant tusk and rhino horn
2024-10-30
In the past, African giant pouched rats have learned to detect explosives and the tuberculosis-causing pathogen. Now, a team of researchers have trained these rats to pick up the scent of pangolin scales, elephant ivory, rhino horn, and African blackwood. These animals and plants are listed as threatened and at high danger of extinction. “Our study shows that we can train African giant pouched rats to detect illegally trafficked wildlife, even when it has been concealed among other substances,” ...

LAST 30 PRESS RELEASES:

Twelve questions to ask your doctor for better brain health in the new year

Microelectronics Science Research Centers to lead charge on next-generation designs and prototypes

Study identifies genetic cause for yellow nail syndrome

New drug to prevent migraine may start working right away

Good news for people with MS: COVID-19 infection not tied to worsening symptoms

Department of Energy announces $179 million for Microelectronics Science Research Centers

Human-related activities continue to threaten global climate and productivity

Public shows greater acceptance of RSV vaccine as vaccine hesitancy appears to have plateaued

Unraveling the power and influence of language

Gene editing tool reduces Alzheimer’s plaque precursor in mice

TNF inhibitors prevent complications in kids with Crohn's disease, recommended as first-line therapies

Twisted Edison: Bright, elliptically polarized incandescent light

Structural cell protein also directly regulates gene transcription

Breaking boundaries: Researchers isolate quantum coherence in classical light systems

Brain map clarifies neuronal connectivity behind motor function

Researchers find compromised indoor air in homes following Marshall Fire

Months after Colorado's Marshall Fire, residents of surviving homes reported health symptoms, poor air quality

Identification of chemical constituents and blood-absorbed components of Shenqi Fuzheng extract based on UPLC-triple-TOF/MS technology

'Glass fences' hinder Japanese female faculty in international research, study finds

Vector winds forecast by numerical weather prediction models still in need of optimization

New research identifies key cellular mechanism driving Alzheimer’s disease

Trends in buprenorphine dispensing among adolescents and young adults in the US

Emergency department physicians vary widely in their likelihood of hospitalizing a patient, even within the same facility

Firearm and motor vehicle pediatric deaths— intersections of age, sex, race, and ethnicity

Association of state cannabis legalization with cannabis use disorder and cannabis poisoning

Gestational hypertension, preeclampsia, and eclampsia and future neurological disorders

Adoption of “hospital-at-home” programs remains concentrated among larger, urban, not-for-profit and academic hospitals

Unlocking the mysteries of the human gut

High-quality nanodiamonds for bioimaging and quantum sensing applications

New clinical practice guideline on the process for diagnosing Alzheimer’s disease or a related form of cognitive impairment or dementia

[Press-News.org] Comparative metabolism of the humantenirine in liver microsomes from pigs, goats, and humans