PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

New study traces impact of COVID-19 pandemic on global movement and evolution of seasonal flu

2024-11-07
(Press-News.org) UNDER EMBARGO UNTIL 19:00 GMT / 14:00 US EASTERN TIME THURSDAY 7 NOVEMBER 2024 Increased capabilities for genomic surveillance have offered new insights into global viral evolution; Seasonal flu showed a ‘remarkable’ bounce back to pre-pandemic levels once international air travel resumed; Regions with fewer COVID-19 restrictions were associated with sustained flu virus transmission. Seasonal influenza epidemics impose substantial burdens on healthcare systems and cause >5 million hospitalizations of adults each year. The current approach to influenza vaccine development requires comprehensive surveillance of circulating strains, which are constantly moving from continent to continent. The reduction in global human mobility during the COVID-19 pandemic provided a unique opportunity to evaluate how seasonal influenza is impacted during pandemics.

In this new study, an international team of researchers, including from the University of Oxford, Fudan University, and KU Leuven, combined data on the spread of seasonal influenza, its genetic makeup, and international travel patterns to study how seasonal flu viruses moved and evolved. This approach helped to estimate how long the viruses remained in certain regions during periods of high and low volumes of international travel and how their genetic diversity changed before, during, and after the COVID-19 pandemic.

During the COVID-19 pandemic, seasonal influenza levels dropped worldwide due to COVID-19 pandemic-related restrictions on population movement and mixing. However, the subsequent rapid bounce back of influenza once air travel returned to pre-pandemic levels showed that the virus was in most cases maintained during the pandemic with continued viral movements and accumulation of genetic diversity.

Lead author of the study Zhiyuan Chen (University of Oxford and Fudan University) says “It was remarkable how quickly seasonal flu re-established to a pre-pandemic equilibrium just a few years after the height of the COVID-19 pandemic.”

Tropical climates, like those found across South and East Asia, allow for continued flu transmission year-round, thereby creating a broader range of flu strains and increasing overall viral diversity. The increased capacity for virus genomic surveillance during the COVID-19 pandemic has provided more detail on the role of other regions, such as Africa and West Asia, in the global circulation of influenza. These regions also showed evidence of sustained transmission and during the pandemic had relatively less restrictions on movement, in part due to lower levels of COVID-19 transmission.

Co-author Professor Moritz Kraemer (Department of Biology and Pandemic Sciences Institute, University of Oxford) says: “Increased genomic surveillance capacity established during the COVID-19 pandemic means that we are finally getting a deeper insight into the global distribution patterns of seasonal flu and other respiratory viruses. These novel and large openly accessible datasets provide an opportunity to learn about the intricate relationships of climate, co-circulating viruses, and human behaviour.”

Further, with this increased global capacity for surveillance of viruses it might be possible to better monitor seasonal influenza to reduce the risk of vaccine mismatches, help inform more effective interventions, and reduce the burden of seasonal influenza on our healthcare systems. This is especially relevant as more regions become suitable for year-round circulation of influenza with changes in climatic conditions.

Co-author Professor Hongjie Yu from Fudan University says: “Further efforts should still focus on the continuing surveillance of seasonal influenza viruses and other respiratory pathogens, particularly resource-limited regions. The established surveillance systems for seasonal respiratory pathogens could also play an extremely vital role when the next pandemic emerges in the future.”

Notes to editors The paper ‘COVID-19 pandemic interventions reshaped the global dispersal of seasonal influenza viruses’ will be published in the journal Science at https://doi.org/10.1126/science.adq3003.  Advance copies of the paper may be obtained from the Science press package, SciPak, at https://www.eurekalert.org/press/scipak/ or by contacting scipak@aaas.org.

Interviews with the corresponding author are available on request.

Media contact: Professor Moritz Kraemer: moritz.kraemer@biology.ox.ac.uk

About the University of Oxford

Oxford University has been placed number 1 in the Times Higher Education World University Rankings for the ninth year running, and ​number 3 in the QS World Rankings 2024. At the heart of this success are the twin-pillars of our ground-breaking research and innovation and our distinctive educational offer.

Oxford is world-famous for research and teaching excellence and home to some of the most talented people from across the globe. Our work helps the lives of millions, solving real-world problems through a huge network of partnerships and collaborations. The breadth and interdisciplinary nature of our research alongside our personalised approach to teaching sparks imaginative and inventive insights and solutions.

Through its research commercialisation arm, Oxford University Innovation, Oxford is the highest university patent filer in the UK and is ranked first in the UK for university spinouts, having created more than 300 new companies since 1988. Over a third of these companies have been created in the past five years. The university is a catalyst for prosperity in Oxfordshire and the United Kingdom, contributing £15.7 billion to the UK economy in 2018/19, and supports more than 28,000 full time jobs.

The Department of Biology is a University of Oxford department within the Maths, Physical, and Life Sciences Division. It utilises academic strength in a broad range of bioscience disciplines to tackle global challenges such as food security, biodiversity loss, climate change and global pandemics. It also helps to train and equip the biologists of the future through holistic undergraduate and graduate courses. For more information visit www.biology.ox.ac.uk.

 

END


ELSE PRESS RELEASES FROM THIS DATE:

Presenting a Janus channel of membranes for complete oil-and-water separation

2024-11-07
Named after the two-faced Roman god Janus to reflect its dual-purpose design, researchers present a novel membrane system – a Janus channel of membranes (JCM) – capable of simultaneously separating oil and water from complex emulsions. The system addresses a critical challenge for sustainable water and oil reclamation across various industries. Separating oil and water from complex mixtures is essential for many scientific and industrial applications, such as wastewater treatment and biological sorting. Membrane ...

COVID-19 restrictions altered global dispersal of influenza viruses

2024-11-07
Although travel restrictions and social measures during the COVID-19 pandemic led to a dramatic global drop in seasonal influenza cases, certain influenza lineages in specific regions kept the virus circulating and evolving, according to a new study. This was true in tropical areas with fewer travel restrictions, for example, including South and West Asia. The spread of seasonal influenza is closely tied to social behavior, particularly air travel, and to the periodic evolution of new virus strains that evade immunity from prior infections or vaccinations. In 2020, nonpharmaceutical interventions (NPIs) introduced to combat COVID-19 – such as ...

Disconnecting hepatic vagus nerve restores balance to liver and brain circadian clocks, reducing overeating in mice

2024-11-07
Disruptions between the brain’s master circadian clock and the liver’s internal clock, communicated via the hepatic afferent vagal nerve (HVAN), can lead to unhealthy eating patterns and increased weight gain, according to a new study in mice. The findings identify the neural link as a potential therapeutic target for obesity and metabolic dysfunction related to circadian disruption. In mammals, circadian rhythms are controlled by the suprachiasmatic nucleus (SCN) – a small part of the brain’s hypothalamus that regulates the body’s circadian rhythms. This cycle triggers a feedback loop involving key clock genes that keep ...

Mechanosensory origins of “wet dog shakes” – a tactic used by many hairy mammals – uncovered in mice

2024-11-07
“Wet dog shakes” – a common reflex behavior shared among many hairy mammals and designed to expel water and irritants from their coats – happens when particular mechanoreceptors are activated, researchers studying mice report. Many furry mammals engage in rapid body twists known as "wet dog shakes" to effectively remove water from their fur, as well as to eliminate irritants like tangles or parasites, particularly in areas on the neck and back that are largely unreachable by self-grooming or licking. However, despite the commonality of this behavior ...

New study links liver-brain communication to daily eating patterns

2024-11-07
PHILADELPHIA— People who work the nightshift or odd hours and eat at irregular times are more prone to weight gain and diabetes, likely due to eating patterns not timed with natural daylight and when people typically eat. But is it possible to stave off the ill effects of eating at these “unusual” times despite it not being biologically preferable? A new study from the Perelman School of Medicine at the University of Pennsylvania says ‘yes’, and sheds light on how the body knows when to eat. The study, published today in Science, explains how researchers discovered a connection between the liver's internal clock and feeding centers in the ...

Defense or growth – How plants allocate resources

2024-11-07
The more a plant species invests in defense, the less potential it has for growth, according to a new study. Research made possible by open science provides new insights into plant adaptation and interspecies variation. Pathogens can significantly weaken the fitness of their hosts, sometimes even causing host mortality. Yet considerable variation is found between species in their investment in disease defense. Evolutionary theory predicts that allocation costs regulate this investment, but testing this hypothesis ...

Study identifies hip implant materials with the lowest risk of needing revision

2024-11-07
Hip implants with a delta ceramic or oxidised zirconium head and highly crosslinked polyethylene liner or cup had the lowest risk of revision during the 15 years after surgery, a new study led by the University of Bristol has found.  The research could help hospitals, surgeons and patients to choose what hip implant to use for replacement surgery. The aim of the study was to establish hip implant materials at risk of revision to help orthopaedic surgeons, and patients, and to improve shared decision making ...

Study reveals how plants grow thicker, not just taller

Study reveals how plants grow thicker, not just taller
2024-11-07
Most research on plant stem cells focuses on the tips of roots and shoots, where growth occurs in height. But Ten Tusscher explains that thickness growth is just as essential. “Plants can’t grow endlessly in height. They also need to grow in thickness, or they would simply fall over,” she says. The growth in thickness, is what makes older trees visibly thicker and more robust over time. This growth is essential for structural strength, particularly in trees. Stem cells in the plant’s cambium layer control this width growth, producing wood to support the plant’s structure. However, which genes enable these cambium stem cells to become active ...

Insect-killing fungi find unexpected harmony in war

Insect-killing fungi find unexpected harmony in war
2024-11-07
University of Maryland entomologists uncovered a unique relationship between two species of fungi known for their ability to invade, parasitize and kill insects efficiently. Instead of violently competing for the spoils of war, the two fungi peacefully cooperate and share their victims. The findings, published in the journal Public Library of Science (PLOS) Pathogens on November 7, 2024, offer insight into some of the biggest evolutionary successes in nature’s history, according to study co-authors Raymond St. Leger, a Distinguished University Professor of Entomology, and entomology Ph.D. candidate Huiyu Sheng. “It’s not survival ...

Unlocking predictors of success in treating inflammatory bowel disease (IBD)

Unlocking predictors of success in treating inflammatory bowel disease (IBD)
2024-11-07
Not everyone responds equally well to treatments for inflammatory bowel disease (IBD). What will work for individual patients involves trial and error during the treatment process. Now, a team of researchers led by Charité – Universitätsmedizin, in collaboration with colleagues in Berlin and Bonn, has succeeded in identifying a biomarker that indicates whether or not treatment with a certain medication called an immunomodulator will be successful. Writing in the journal Gastroenterology,* the researchers note that this will permit more targeted use of the therapy. Inflammatory bowel disease (IBD) takes multiple ...

LAST 30 PRESS RELEASES:

Researchers develop robotic sensory cilia that monitor internal biomarkers to detect and assess airway diseases

Could crowdsourcing hold the key to early wildfire detection?

Reconstruction of historical seasonal influenza patterns and individual lifetime infection histories in humans based on antibody profiles

New study traces impact of COVID-19 pandemic on global movement and evolution of seasonal flu

Presenting a Janus channel of membranes for complete oil-and-water separation

COVID-19 restrictions altered global dispersal of influenza viruses

Disconnecting hepatic vagus nerve restores balance to liver and brain circadian clocks, reducing overeating in mice

Mechanosensory origins of “wet dog shakes” – a tactic used by many hairy mammals – uncovered in mice

New study links liver-brain communication to daily eating patterns

Defense or growth – How plants allocate resources

Study identifies hip implant materials with the lowest risk of needing revision

Study reveals how plants grow thicker, not just taller

Insect-killing fungi find unexpected harmony in war

Unlocking predictors of success in treating inflammatory bowel disease (IBD)

New PFAS removal process aims to stamp out pollution ahead of semiconductor industry growth

Researchers identify reduction in heart failure-related risk factors following metabolic surgery

The Kenneth H. Cooper Institute at Texas Tech University Health Sciences Center unveiled in Dallas

DNA evidence rewrites story of people buried in Pompeii eruption

DNA evidence rewrites histories for people buried in volcanic eruption in ancient Pompeii

People with schizophrenia show distinct brain activity when faced with conflicting information

Climate change: Significant increase in carbon dioxide emissions from private aviation

Planting trees in the Arctic could make global warming worse, not better, say scientists

Finding function for noncoding RNAs using a new kind of CRISPR

Neurodevelopment in the first 2 years of life following prenatal exposure to maternal SARS-CoV-2 Infection

Racial disparities in genetic detection rates for inherited retinal diseases

Stem cells shed insight into cardiovascular disease processes 

New study: Plastics pollution worsen the impacts of all Planetary Boundaries

Long-term risks from prostate cancer treatment detailed in new report

Does more virtual care mean more low-value care? Study suggests no

City of Hope Research Spotlight, October 2024

[Press-News.org] New study traces impact of COVID-19 pandemic on global movement and evolution of seasonal flu