Semaglutide and nonarteritic anterior ischemic optic neuropathy

JAMA Ophthalmology

2025-02-20

(Press-News.org) About The Study: The results of this study suggest a modest increase in the risk of nonarteritic anterior ischemic optic neuropathy among individuals with type 2 diabetes associated with semaglutide use, smaller than that previously reported, and warranting further investigation into the clinical implications of this association.

Corresponding Author: To contact the corresponding author, Cindy X. Cai, MD, MS, email ccai6@jhmi.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamaophthalmol.2024.6555)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/jamaophthalmol.2024.6555?guestAccessKey=9cc7cefb-e963-490d-bbd1-8ad419a0b542&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=022025

END

ELSE PRESS RELEASES FROM THIS DATE:

Inequities in the application of behavioral flags for hospitalized pediatric patients

2025-02-20

About The Study: This cohort study found significant inequities in incidence of behavioral flags in the electronic health record among racially and socioeconomically marginalized pediatric patients. This finding was most pronounced for Black or African American patients younger than 8 years, suggesting that this phenomenon may be a response to Black families rather than specific patient behavior. Corresponding Author: To contact the corresponding author, April Edwell, MD, MAEd, email April.edwell@ucsf.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.61079) Editor’s ...

Paxlovid’s impact on hospitalization and death in COVID-vaccinated older adults far weaker than previously thought

2025-02-20

Paxlovid does not significantly reduce COVID-19 hospitalization and mortality among vaccinated older adults, according to new UCLA-led research. The study questions the assumption that Paxlovid’s effectiveness in reducing COVID-19 hospitalizations and deaths in unvaccinated adults also applies to vaccinated adults. Pfizer’s 2022 clinical trial found reduced COVID-19 hospitalization in unvaccinated middle-aged adults; while a subsequent 2024 clinical trial found no significant reduction in vaccinated middle-aged adults. Since most older Americans have already received two or more COVID-19 vaccines, Paxlovid’s effectiveness on vaccinated ...

Additive manufacturing of biomedical metals for medical implant fabrication

2025-02-20

Biomedical metal implant materials are widely used in clinical applications, including dental implants, hip replacement, bone plates, and screws. However, traditional manufacturing processes face limitations in meeting customized medical needs, internal structural control, and efficient material utilization. For example, when producing complex-shaped titanium alloy parts using conventional methods, the material consumption ratio is as high as 10:1-20:1, leading to significant material waste. As a result, ...

Antioxidant-enzyme Interaction in non-communicable diseases

2025-02-20

Introduction Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, plays a central role in the development of non-communicable diseases (NCDs). These diseases, including cardiovascular disorders, diabetes, neurodegenerative conditions, cancer, and liver and kidney diseases, are among the leading causes of morbidity and mortality worldwide. Enzymatic and non-enzymatic antioxidants serve as the body’s primary defense against ROS, maintaining redox homeostasis and preventing cellular damage. However, when ROS levels exceed the capacity of antioxidant defenses, oxidative stress ensues, contributing ...

Turtles change nesting patterns in response to climate change

2025-02-20

New research shows that turtles are responding to climate change by nesting earlier. Researchers monitoring nesting green and loggerhead turtles in Cyprus have discovered they are returning to their regular nesting spots earlier each year to compensate for rising temperatures. In sea turtles, temperature determines the biological sex of offspring, with more females born when it is warmer, as well as fewer successful hatchings when it gets too hot. Turtles also have “natal philopatry”, which means they return to nest in the area where they themselves hatched. A research team from the University of Exeter and the Society for the Protection of ...

New research links grape consumption to improved muscle health in both men and women

2025-02-20

A new study from Western New England University (WNE) has revealed that long-term grape consumption significantly impacts muscle health, with notable benefits for both men and women. The research, published in the journal Foods, suggests that a diet including grapes can modify gene expression in muscle, potentially offering a new nutritional strategy for maintaining muscle mass and function. Around 30 million tons of grapes are consumed every year, and their benefits extend beyond nutrition. Grapes have been shown to ...

Both sides of the coin: Lack of consensus on continuing vs. discontinuing opioid medications prescriptions for adults with chronic pain

2025-02-20

INDIANAPOLIS – Chronic pain is complex and difficult to treat. Prescribing opioid pain medications has become controversial but may help some patients. With the goal of informing clinician practice, a new study explores the harms and benefits of continuing and of discontinuing the long-term prescription of opioid medicines to adults with chronic pain. The authors analyzed the opinions of 28 experts on the harms versus benefits of maintaining, tapering or terminating opioid pain medication prescriptions ...

National Academy of Inventors welcomes 162 emerging inventors

2025-02-20

The National Academy of Inventors (NAI) has announced the 2025 class of Senior Members, comprised of 162 emerging inventors from NAI’s Member Institutions. This year’s class of NAI Senior Members is the largest to date and hails from 64 NAI Member Institutions across the nation. Collectively, they are named inventors on over 1200 U.S. patents. “To see this program grow year over year is a testament to the dedication our Member Institutions have to fostering innovation on their campuses and supporting their inventive staff ...

Narcissists more likely to feel ostracized

2025-02-20

Narcissists feel ostracized more frequently than their less self-absorbed peers, according to research published by the American Psychological Association. This may stem not only from being shunned due to their personalities but from a tendency to misinterpret ambiguous social signals as exclusion. “Feeling ostracized is a subjective experience based on the perception of social cues by the individual. Some may be intentionally ostracized, while others may merely believe they are being excluded when that’s not the case,” said lead author Christiane Büttner, PhD, of the University of Basel. “Our findings suggest that ...

Unfolded protein response: A key regulator of intestinal health and disease

2025-02-20

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system. To maintain homeostasis, intestinal epithelial cells (IECs) must efficiently manage protein production and secretion, a process tightly controlled by the unfolded protein response (UPR). New research published in eGastroenterology demonstrates that disruptions in the UPR contribute to inflammatory bowel diseases (IBD), colorectal cancer, and other gut-related disorders. This highlights potential therapeutic strategies to restore ...

ACS Central Science | Researchers from Insilico Medicine and Lilly publish foundational vision for fully autonomous “Prompt-to-Drug” pharmaceutical R&D

Increasing the number of coronary interventions in patients with acute myocardial infarction does not appear to reduce death rates

Striking genomic architecture discovered in embryonic reproductive cells before they start developing into sperm and eggs

AABNet and partners launch landmark guide on the conservation of African livestock genetic resources and sustainable breeding strategies

Produce hydrogen and oxygen simultaneously from a single atom! Achieve carbon neutrality with an 'All-in-one' single-atom water electrolysis catalyst

Sleep loss linked to higher atrial fibrillation risk in working-age adults

Visible light-driven deracemization of α-aryl ketones synergistically catalyzed by thiophenols and chiral phosphoric acid

Babies with an increased likelihood of autism may struggle to settle into deep, restorative sleep, according to a new study from the University of East Anglia.

National Reactor Innovation Center opens Molten Salt Thermophysical Examination Capability at INL

International Progressive MS Alliance awards €6.9 million to three studies researching therapies to address common symptoms of progressive MS

[Press-News.org] Semaglutide and nonarteritic anterior ischemic optic neuropathy
JAMA Ophthalmology

Semaglutide and nonarteritic anterior ischemic optic neuropathy

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: