New AI tool visualizes a cell’s ‘social network’ to help treat cancer

(Press-News.org) A first-of-its-kind artificial intelligence (AI)-based neural network can rapidly analyse and interpret millions of cells from a patient sample, predicting molecular changes in the tissue. It can potentially pinpoint where personalised treatments could be most effective for conditions such as cancer.

NicheCompass leverages the power of generative AI to create a visual database combining spatial genomic data on cell types, where they are found, and how they communicate. Created by researchers at the Wellcome Sanger Institute, the Institute of AI for Health at Helmholtz Munich, the University of Würzburg, and their collaborators as part of the wider Human Cell Atlas Initiative1, this is the first AI method capable of measuring and interpreting a range of data from a cell's social network to recognise and analyse different cellular neighbourhoods.

A new paper, published today (18 March) in Nature Genetics, introduces NicheCompass and details how it can uncover tissue changes across breast and lung cancer patients. Researchers show how NicheCompass can identify how certain people may respond differently to treatment — all in one hour, through the power of AI. Ultimately, it will help develop personalised therapy plans, highlighting specific changes that could be targeted in conditions such as cancer.

Every cell in the human body communicates with its environment and is involved in a larger network of interactions. Cells all have features that allow them to be recognised as part of their communication networks, such as which proteins they have on their surface. It is possible to connect similar cells through their features.

Single-cell and spatial genomic technologies2 have revolutionised our understanding of the human body, and enabled the creation of multiple in-depth cell atlases of different tissues and organs.

These atlases contain information on the multitude of cell types, where they are, and how genetic changes can impact how they interact with each other. By understanding how the human body works at a cellular level, it can inform our understanding of what happens in disease, and highlight new targets for drug development.

While these atlases include information about where cells are found and how they interact within their specific neighbourhoods or networks, it is difficult to quantify and interpret these neighbourhoods and understand what drives the social interactions of cells.

In a new study, Sanger Institute researchers and their collaborators present NicheCompass, a deep-learning AI model that is based on cell-to-cell communication. This means that it learns how different cells communicate through their networks and then aligns these with similar networks of cells, creating neighbours within tissues through shared features.

From this, NicheCompass can interpret the data, allowing researchers and clinicians to ask questions about the data and better understand health conditions. For example: ‘How do cancer cells communicate with the environment around them in patients with lung cancer?’.

Using NicheCompass, researchers combined data from 10 patients with lung cancer and were able to see the similarities and differences between individuals. The similarities help inform our general understanding of cancer, as well as highlight any transcriptional changes that might be useful to target in new treatments. Comparatively, the differences highlight new possible avenues for personalised medicine.

Further patient data can be included, so clinicians can input their own patient data and in one hour receive in-depth information about an individual condition, helping to guide clinical decisions.

The team also used NicheCompass on breast cancer tissue, showing its effectiveness across different types of cancer.

They also applied this network to a mouse brain spatial atlas with 8.4 million cells, and it was able to rapidly and correctly identify brain sections and create a visual resource of the entire organ. This demonstrates how it can be applied to spatial atlases of whole organs generated by researchers worldwide.

Sebastian Birk, first author at the Institute of AI for Health, Helmholtz Munich and the Wellcome Sanger Institute, said: “Having a huge amount of data about the human body is crucial to finding new ways to understand, prevent and treat disease. However, we also need tools that allow us to access all the benefits this information could provide. NicheCompass is a significant leap in this field, leveraging the power of AI but also offering interpretability, allowing researchers and clinicians to ask questions about their data and better understand and treat diseases.”

Dr Carlos Talavera-López, co-senior author at the University of Würzburg, said: “Using NicheCompass, we were able to see the differences in how immune cells interact with lung cancer tumours in patients. This real-world application not only uncovered new information that adds to our collective understanding about cancer, it also highlighted one patient whose cancer interacted with the immune system differently. In the future, NicheCompass could help uncover new ways to harness the immune system in certain cancers, creating personalised treatments that empower a patient’s immune system to target the cancer mechanisms directly.”  

Dr Mohammad Lotfollahi, co-senior author at the Wellcome Sanger Institute, said: “People often communicate to their networks with a range of different information. They might share developments from work, or pictures of their holidays, and while these might be to different friends, they can all be traced back to one individual. Cell-to-cell communication is similar, cells might use different features to communicate with their social network, creating communities or networks in their local area. NicheCompass is the first AI model of its kind that can interpret these networks and answer questions that could directly impact patient lives, such as highlighting where and how health conditions have started, and predicting how they might respond to certain treatments.”

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Notes to Editors

The Human Cell Atlas (HCA), an international collaborative consortium which is creating comprehensive reference maps of all human cells — the fundamental units of life — as a basis for understanding human health and for diagnosing, monitoring, and treating disease. The HCA is likely to impact every aspect of biology and medicine, propelling translational discoveries and applications and ultimately leading to a new era of precision medicine. The HCA was co-founded in 2016 by Dr Sarah Teichmann, then at the Wellcome Sanger Institute (UK) and Dr Aviv Regev, then at the Broad Institute of MIT and Harvard (USA). A truly global initiative, there are now more than 3,906 HCA members, from 104 countries around the world. https://www.humancellatlas.org. Single-cell genomic sequencing allows researchers to gain all the genetic information about an individual cell, helping understand all different cell types at a high resolution. Spatial technologies allow scientists to see what and where cells are in an environment, such as a tissue. Publication:

S. Birk, I. Bonafonte-Pardàs, A. Miraki Feriz, et al. (2025) ‘Quantitative characterization of cell niches in spatially-resolved omics data’. Nature Genetics. DOI: 10.1038/s41588-025-02120-6

Funding:

This research includes funding from the Knut and Alice Wallenberg Foundation, the Swedish Cancer

Society and the Swedish Brain Foundation. A full acknowledgements list can be found in the publication.

Selected websites:

About Helmholtz Munich: 

Helmholtz Munich is a leading biomedical research center. Its mission is to develop breakthrough solutions for better health in a rapidly changing world. Interdisciplinary research teams focus on environmentally triggered diseases, especially the therapy and prevention of diabetes, obesity, allergies, and chronic lung diseases. With the power of artificial intelligence and bioengineering, researchers accelerate the translation to patients. Helmholtz Munich has around 2,500 employees and is headquartered in Munich/Neuherberg. It is a member of the Helmholtz Association, with more than 43,000 employees and 18 research centers the largest scientific organization in Germany. More about Helmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH): www.helmholtz-munich.de/en  

The Wellcome Sanger Institute

The Wellcome Sanger Institute is a world leader in genomics research. We apply and explore genomic technologies at scale to advance understanding of biology and improve health. Making discoveries not easily made elsewhere, our research delivers insights across health, disease, evolution and pathogen biology. We are open and collaborative; our data, results, tools, technologies and training are freely shared across the globe to advance science.

Funded by Wellcome, we have the freedom to think long-term and push the boundaries of genomics. We take on the challenges of applying our research to the real world, where we aim to bring benefit to people and society.

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About Wellcome

Wellcome supports science to solve the urgent health challenges facing everyone. We support discovery research into life, health and wellbeing, and we’re taking on three worldwide health challenges: mental health, infectious disease and climate and health. https://wellcome.org/ 

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