(Press-News.org) Excess weight in mid-life is a known risk factor for kidney cancer, but new research indicates that weight patterns throughout life may also affect an individual’s likelihood of developing this malignancy. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.
To assess weight patterns and their associations with kidney cancer and its different subtypes, investigators analyzed information on 204,364 individuals from the NIH-AARP Diet and Health Study, including body mass index (BMI) data when participants entered the study (an average age of 61.6 years), and prior BMI recordings at 18, 35, and 50 years of age. The team noted that there were 1,425 cases of kidney cancer, or renal cell carcinoma (RCC), among the study’s participants, with 583 having aggressive RCC and 339 having fatal RCC. The researchers also recorded the different subtypes of RCC, including clear cell RCC (541 patients), papillary RCC (146 patients), and chromophobe RCC (64 patients).
Higher BMI at any of the ages assessed was linked with higher risks of overall RCC and all subtypes (except chromophobe RCC), with a 10-40% higher risk for each 5-unit increase in BMI. Similar increased risks were linked to weight gain during adulthood that resulted in overweight or obesity, compared with maintaining normal BMI.
Also, long-term excess weight was associated with higher risks of overall RCC, aggressive RCC, fatal RCC, and clear cell RCC, but not papillary RCC and chromophobe RCC. Weight loss in which BMI was reduced by at least 10%, particularly later in life, was associated with a lower risk of RCC. Specifically, weight loss from age 18–35 years and after age 50 years was associated with 21% and 28% reductions in RCC incidence, respectively.
“These findings emphasize that maintaining a healthy weight across one’s lifetime is important for reducing RCC risk. More importantly, weight loss, even later in life, may offer protective benefits,” said lead author Zhengyi Deng, PhD, of Stanford University School of Medicine. “We should support initiatives that promote healthy weight maintenance and weight loss strategies. Some of these include lifestyle interventions, weight-loss programs, and emerging medical treatments for obesity; however, individuals should consult with their healthcare providers prior to initiation of any plan.”
Additional information
NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. A free abstract of this article will be available via the CANCER Newsroom upon online publication. For more information or to obtain a PDF of any study, please contact: Sara Henning-Stout, newsroom@wiley.com
Full Citation:
“Lifetime body weight patterns, weight loss, and renal cell carcinoma subtypes.” Zhengyi Deng, Chiyuan Amy Zhang, Justin X. Moore, Saira Khan, Rebecca E. Graff, Ken Batai, Melissa L. Bondy, Benjamin I. Chung, and Marvin E. Langston. CANCER; Published Online: March 24, 2025 (DOI: 10.1002/cncr.35763).
URL Upon Publication: http://doi.wiley.com/10.1002/cncr.35763
Author Contact: Ahmad Zaki Sadeqi, MSc, MA; Communications Manager, Department of Urology, Stanford University School of Medicine; azsadeqi@stanford.edu
About the Journal
CANCER is a peer-reviewed publication of the American Cancer Society integrating scientific information from worldwide sources for all oncologic specialties. The objective of CANCER is to provide an interdisciplinary forum for the exchange of information among oncologic disciplines concerned with the etiology, course, and treatment of human cancer. CANCER is published on behalf of the American Cancer Society by Wiley and can be accessed online. Follow CANCER on X @JournalCancer and Instagram @ACSJournalCancer, and stay up to date with the American Cancer Society Journals on LinkedIn.
About Wiley
Wiley is one of the world’s largest publishers and a trusted leader in research and learning. Our industry-leading content, services, platforms, and knowledge networks are tailored to meet the evolving needs of our customers and partners, including researchers, students, instructors, professionals, institutions, and corporations. We empower knowledge-seekers to transform today’s biggest obstacles into tomorrow’s brightest opportunities. For more than two centuries, Wiley has been delivering on its timeless mission to unlock human potential. Visit us at Wiley.com. Follow us on Facebook, X, LinkedIn and Instagram.
END
Do lifetime body weight patterns affect kidney cancer risk?
Study links higher body mass index at various ages across adulthood with greater risks of developing different types of kidney cancer.
2025-03-24
ELSE PRESS RELEASES FROM THIS DATE:
AI can predict premature deaths in people with inflammatory bowel disease
2025-03-24
Almost half of people who died with inflammatory bowel disease (IBD) died prematurely, according to a study published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.241117 that used machine learning models to predict death.
Canada has some of the highest rates of IBD worldwide, which includes Crohn disease and ulcerative colitis. People with IBD have shorter life expectancy than people without such diseases, and they can develop other chronic health conditions related to their IBD. The study found that people with IBD are at risk for premature death (defined ...
Household electricity three times more expensive than upcoming ‘eco-friendly’ aviation e-fuels, study reveals
2025-03-24
Existing tax policies during the energy transition from fossil fuels to renewable sources will lead to major energy injustices and skewed priorities, new research published in Climate Policy shows.
The peer-reviewed study found that electricity serving primary needs, such as heating or lighting, ultimately costs three times more than electricity for tertiary needs such as long-distance mobility – mostly due to taxation policies.
Further highlighting the ongoing social inequalities of fuel and related policies, the findings also demonstrate within the European Union (EU), the wealthiest 1% of all its population is responsible for 66% of the distance ...
Urine test could halve post-op scans for kidney cancer
2025-03-24
A simple urine test could accurately show the recurrence of kidney cancer at an early stage, potentially sparing patients invasive scans and enabling faster access to treatment, new research has shown.
The findings are presented today [Monday 24 March 2025] at the European Association of Urology (EAU) Congress in Madrid and have been accepted for publication in European Urology Oncology.
The test analyses the distinctive profiles of certain types of sugar molecules, called glycosaminoglycans which are found in urine. These profiles are known as the GAGome.
The international AURORAX-0087A (AUR87A) study is assessing whether a GAGome test can accurately detect ...
Thousands of lives could be saved by combining two cholesterol-lowering drugs
2025-03-23
London, UK: The largest analysis to examine the best way to lower levels of ‘bad’ cholesterol in patients with blocked arteries shows that they should immediately be given a combination of a statin and another drug called ezetimibe, rather than statins alone. This could prevent thousands of deaths a year from heart attacks, strokes and other cardiovascular diseases.
The meta-analysis of 108,353 patients in 14 studies who were at very high risk of suffering heart attack or stroke, or who had already suffered one of these cardiovascular events is published in the journal Mayo Clinic Proceedings ...
High resolution ultrasound could enable faster prostate cancer diagnosis
2025-03-23
Biopsies guided by high resolution ultrasound are as effective as those using MRI in diagnosing prostate cancer, an international clinical trial has shown.
The technology, called micro-ultrasound, is cheaper and easier to use than MRI. It could significantly speed up diagnosis, reduce the need for multiple hospital visits and free up MRI for other uses, researchers say.
The results of the OPTIMUM trial are presented today [Sunday 23 March 2025] at the European Association of Urology Congress in Madrid and published in JAMA.
OPTIMUM is the first randomised trial to compare micro-ultrasound (microUS) guided biopsy with ...
Guardians of the vineyard: Canines and chemistry work to combat powdery mildew
2025-03-23
SAN DIEGO, March 23, 2025 — Dogs have many jobs but one you may not expect is identifying grapevines coated in a destructive and highly contagious fungus. Although dogs can detect serious vine infections by smell, scientists don’t know exactly what odor molecules are triggering the response. Researchers are now analyzing volatile chemicals emanating from grape leaves infected by a fungus called powdery mildew with the goal of improving training for vineyard canines.
Nayelly Rangel, a graduate student at Texas Tech University, will present the team’s results at the spring meeting of the American Chemical Society (ACS). ACS Spring 2025 is being held ...
Improving GLP-1 drug delivery by ‘painting’ it on antibodies
2025-03-23
SAN DIEGO, March 23, 2025 — Glucagon-like peptide-1 (GLP-1) receptor agonists are peptide-based therapeutics for treating diabetes and for weight loss. Unfortunately, shortages and high costs have made it difficult for people to start and maintain treatment. Now, researchers report a drug delivery system that “paints” these peptides directly on the antibodies they target. In studies with mice, the system led to sustained weight loss and prolonged blood sugar management with a GLP-1 injection one fourth that of the standard dose.
Bradley Pentelute, professor of chemistry at the Massachusetts Institute of Technology (MIT), will present his team’s results at the spring ...
Second TB vaccination boosts immunity in bladder cancer patients and reduces cancer recurrence
2025-03-23
Two doses of a simple tuberculosis vaccination after surgery helps the immune system fight cancer cells and could greatly improve patient outcomes for the most common type of bladder cancer, according to a pilot study of 40 patients.
Initial results from the RUTIVAC-1 Trial are presented today [Sunday 23 March 2025] at the European Association of Urology (EAU) Congress in Madrid.
In the randomised controlled trial, administering the vaccine alongside standard treatment led to an elevated immune response, which is known to improve the body’s ability to suppress future tumours. Patients who received the vaccine had no discernible ...
Study of UK biobank reveals link between new-onset type 2 diabetes and some but not all obesity-related cancers
2025-03-22
New research to be presented at this year’s European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14 May) shows that a new diagnosis of type 2 diabetes is linked to a subsequent increase in the risk of developing some, but not all, obesity related cancers. The study is by Owen Tipping, University of Manchester, UK, and Professor Andrew Renehan, National Institute for Health Research (NIHR) Manchester Biomedical Research Centre, Manchester, UK, and colleagues.
Previous research has described associations between type 2 diabetes mellitus (T2D) and higher risk of several obesity-related cancers ...
Waist circumference stronger risk marker than BMI for obesity-related cancer in men, but not women
2025-03-22
Body size and excess weight, conventionally assessed using body mass index (BMI), are well-established risk factors for many types of cancer. However, new research to be presented at this year’s European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14 May) and published in The Journal of the National Cancer Institute shows that waist circumference (WC) is a stronger risk marker than BMI for developing obesity-related cancers in men, but not women. The study was conducted by Dr Ming Sun, Dr Josef Fritz and Dr Tanja Stocks, Lund University, ...
LAST 30 PRESS RELEASES:
Government of Guyana, Mount Sinai Health System and Hess Corporation announce five-year extension of national healthcare initiative.
Preclinical study: after heart attack, a boost in anti-inflammatory cells promoted healing
Glucose revealed as a master regulator of tissue regeneration in Stanford Medicine study
Open-label placebo appears to reduce premenstrual symptoms, study suggests
New mums advised to do two hours of moderate to vigorous exercise a week
Milk as Medicine: New Study Shows Breast Milk Transforms Challenges into Triumphs
CU Cancer Center researchers identify the ‘switch’ that allows intestinal cells to regenerate after injury
Special issue of Academic Emergency Medicine explores the science of errors in emergency care
Organoid fusions as models to study meninges-brain signaling
A multimodal light manipulator
OU researcher leverages technology for alcohol disorder interventions in primary care
Automated lead nurturing boosts sales—but only under the right conditions
Lessons from Venezuela’s democratic collapse: How opposition movements can defy autocratic leaders
USU ecologists document Utah's bee species and say beehive state is rich in bee diversity
A hit of dopamine tells baby birds when their song practice is paying off
Basketball analytics investment is key to NBA wins and other successes
Scientific cooperation is strategic for Brazil to strengthen relations with Europe
Engineering antibodies with a novel fusion protein
Transforming cardiovascular care through upfront combination therapy
URI to host international XV Progress in Motor Control Conference
How Zika virus knocks out our immune defenses
Could an arthritis drug unlock lasting relief from epilepsy and seizures? UW–Madison researchers see promising results in mice
SCAI announces 2025-26 recipients of JSCAI Editorial Fellowship Program
Study unravels mystery of cancer-fueling enzyme—could lead to new therapies
Lupus-related antibody shows promise in enhancing cancer treatment efficacy
BESSY II: Magnetic ‘microflowers’ enhance local magnetic fields
New study may help predict cardiometabolic disease risk and personalize prevention strategies
The Frontiers of Knowledge Award goes to Avelino Corma, John Hartwig and Helmut Schwarz for their founding work on the catalysts that are enabling a more efficient, sustainable chemistry
New software finds aging cells that contribute to disease and health risks
UTA inventors recognized worldwide for innovations
[Press-News.org] Do lifetime body weight patterns affect kidney cancer risk?Study links higher body mass index at various ages across adulthood with greater risks of developing different types of kidney cancer.