PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Exploring binge eating and binge drinking alcohol comorbidity

Mouse study suggests females are more sensitive to the cooccurrence of binge eating and drinking and identifies a protein that prevents this disease comorbidity in both sexes.

2025-03-31
(Press-News.org) The comorbidity of binge eating and alcohol binge drinking is prevalent and increases the risk of other neuropsychiatric and bodily conditions. However, the mechanisms linking these forms of binge consumption are unclear. To explore the link between binge eating and binge drinking alcohol, Karen Szumlinski, from the University of California, Santa Barbara, and colleagues developed a way to model the disease comorbidity in mice. As reported in their JNeurosci paper, this mouse model led to the discovery that females with a history of binge eating start binge drinking alcohol quicker than males. The researchers also found that females had increased levels of a protein previously associated with comorbid alcohol use disorder and eating disorders called phosphodiesterase 4B (PDE4B). Inhibiting the protein prevented cooccurrence of binging in both sexes of mice. According to the authors, this study supports previous work linking PDE4B to problematic alcohol use and eating disorders and may inform future work investigating whether the protein is an effective treatment target. The authors also emphasize that the behavioral paradigm they developed may be useful for preclinical researchers working to unveil more mechanisms linking binge eating and drinking. 

###

Please contact media@sfn.org for full-text PDF.

About JNeurosci

JNeurosci was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors' changing publishing needs, representing breadth of the field and diversity in authorship.

About The Society for Neuroscience

The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 35,000 members in more than 95 countries.

END



ELSE PRESS RELEASES FROM THIS DATE:

The proportion of harmful substances in particulate matter is much higher than assumed

2025-03-31
People breathing contaminated air over the course of years are at greater risk of developing numerous diseases. This is thought to be due to highly reactive components in particulate matter, which affect biological processes in the body. However, researchers from the University of Basel, Switzerland, have now shown that precisely these components disappear within hours and that previous measurements therefore completely underestimate the quantities in which they are present. From chronic respiratory problems to cardiovascular diseases, ...

Administration is weakening U.S. research capacity and endangering Americans, nation’s leading scientists warn

2025-03-31
The wellbeing of Americans and the country’s longstanding position as a world leader in science and technology are in jeopardy due to the actions of the Trump administration, approximately 1,900 leading figures in medicine, science, and engineering warn today in an open statement to the American public. The list of signatories includes Nobel Prize winners, deans of medical schools, and national leaders in science and technology. “For over 80 years, wise investments by the US government have built up the nation’s research enterprise, making it the envy of ...

Trade Tariffs on Canadian Pharmaceuticals— Implications for US Drug Supply and Costs

2025-03-31
About The Study: Although Canada is not the largest supplier of medications to the U.S., tariffs could raise costs and strain supply chains. This study estimates that $3 billion in U.S. pharmaceuticals depend on Canadian manufacturing, with 25% tariffs adding $750 million in cost. Although the Inflation Reduction Act provisions limit cost pass-through to some payers (i.e., Medicare), manufacturers may still adjust production or alter distribution, increasing supply chain fragility. Corresponding Author: To contact the corresponding author, Mina Tadrous, PharmD, PhD, email mina.tadrous@utoronto.ca. To access the embargoed study: Visit our For The Media website ...

Cardiovascular Health Among Rural and Urban US Adults— Healthcare, Lifestyle, and Social Factors

2025-03-31
About The Study: This national cross-sectional study found substantial rural-urban disparities in cardiometabolic risk factors and cardiovascular diseases, which were largest among younger adults and almost entirely explained by social risk factors. These findings suggest that efforts to improve socioeconomic conditions in rural communities may be critical to address the rural-urban gap in cardiovascular health. Corresponding Author: To contact the corresponding author, Rishi K. Wadhera, MD, MPP, MPhil, email rwadhera@bidmc.harvard.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamacardio.2025.0538) Editor’s ...

Study finds gap between heart disease outcomes in men and women has narrowed over past 20 years

Study finds gap between heart disease outcomes in men and women has narrowed over past 20 years
2025-03-31
While the typical image of someone suffering a heart attack might be a man clutching his chest, heart disease is a major problem for women, too. In fact, it’s the leading cause of death among women in the United States, with nearly 45% of the nation’s women over age 20 living with some form of cardiovascular disease. A new study from heart researchers at Intermountain Health in Salt Lake City shows that while rates of death and other cardiac-related events – like heart attack ­– are still high for women, the ...

New study links lower proportions of certain sleep stages to brain changes associated with Alzheimer’s disease

2025-03-31
DARIEN, IL — New research reveals that lower proportions of specific sleep stages are associated with reduced brain volume in regions vulnerable to the development of Alzheimer’s disease over time. Results show that individuals with lower proportions of time spent in slow wave sleep and rapid eye movement sleep had smaller volumes in critical brain regions, particularly the inferior parietal region, which is known to undergo early structural changes in Alzheimer’s disease. The results were adjusted for potential confounders including demographic characteristics, smoking history, alcohol use, hypertension, and coronary heart disease. “Our findings provide ...

Long-term practice of Transcendental Meditation may reduce both stress and aging

Long-term practice of Transcendental Meditation may reduce both stress and aging
2025-03-31
A collaborative study conducted by researchers at Maharishi International University (MIU), the University of Siegen, and the Uniformed Services University of the Health Sciences reveals that individuals practicing Transcendental Meditation® (TM®) technologies long-term show favorable biological markers of aging and stress. The research compared gene expression, cognitive function (via EEG), and hair glucocorticoids (cortisol and cortisone) in 12-year and 40-year TM groups and non-meditator controls. “This study provides evidence that long-term practice of TM technologies has a broad range of health benefits at the molecular ...

Delicate balancing act determines how many genome gateways form in cells

Delicate balancing act determines how many genome gateways form in cells
2025-03-31
EMBARGOED UNTIL MONDAY, MARCH 31 – 11:00 AM Eastern The nuclei in our cells are miniature warehouses safeguarding the genetic blueprint for the body’s biologic machinery. As warehouses go, nuclei are more like libraries than bank vaults. Too many cellular components need access to the genome to lock it down like Fort Knox. Instead, large groupings of more than 1,000 individual protein molecules called nuclear pore complexes (NPCs) pepper the dividing membrane, serving as gateways for materials and messages entering and exiting the nucleus. While the basic need for this shuttle service is constant, ...

Postpartum hormonal contraceptive use and risk of depression

2025-03-31
About The Study: Hormonal contraceptive initiation postpartum was associated with an instantaneous increased risk of developing depression in this cohort study. The associated risk was higher the earlier it was initiated postpartum, at least for combined oral contraceptives. This finding raises the issue of whether the incidence of depression postpartum is increased by routine hormonal contraceptive initiation after childbirth. Corresponding Author: To contact the corresponding author, Vibe Gedsø Frokjaer, PhD, email vibe.frokjaer@nru.dk. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.2474) Editor’s ...

CU research poised to change oxygen standards for trauma patients

2025-03-31
When a critically injured patient is admitted to the hospital, how much supplemental oxygen should they receive? New research published this week in JAMA Network Open led by investigators at the University of Colorado School of Medicine suggests it’s often less than the current standard.   “The idea has traditionally been that severe trauma causes stress to patients’ bodies, and we want to deliver as much oxygen as possible to the brain and to vital organs because they are losing blood,” says Adit Ginde, MD, MPH, professor ...

LAST 30 PRESS RELEASES:

Program takes aim at drinking, unsafe sex, and sexual assault on college campuses

Inability to pay for healthcare reaches record high in U.S.

Science ‘storytelling’ urgently needed amid climate and biodiversity crisis

KAIST Develops Retinal Therapy to Restore Lost Vision​

Adipocyte-hepatocyte signaling mechanism uncovered in endoplasmic reticulum stress response

Mammals were adapting from life in the trees to living on the ground before dinosaur-killing asteroid

Low LDL cholesterol levels linked to reduced risk of dementia

Thickening of the eye’s retina associated with greater risk and severity of postoperative delirium in older patients

Almost one in ten people surveyed report having been harmed by the NHS in the last three years

Enhancing light control with complex frequency excitations

New research finds novel drug target for acute myeloid leukemia, bringing hope for cancer patients

New insight into factors associated with a common disease among dogs and humans

Illuminating single atoms for sustainable propylene production

New study finds Rocky Mountain snow contamination

Study examines lactation in critically ill patients

UVA Engineering Dean Jennifer West earns AIMBE’s 2025 Pierre Galletti Award

Doubling down on metasurfaces

New Cedars-Sinai study shows how specialized diet can improve gut disorders

Making moves and hitting the breaks: Owl journeys surprise researchers in western Montana

PKU Scientists simulate the origin and evolution of the North Atlantic Oscillation

ICRAFT breakthrough: Unlocking A20’s dual role in cancer immunotherapy

How VR technology is changing the game for Alzheimer’s disease

A borrowed bacterial gene allowed some marine diatoms to live on a seaweed diet

Balance between two competing nerve proteins deters symptoms of autism in mice

Use of antifungals in agriculture may increase resistance in an infectious yeast

Awareness grows of cancer risk from alcohol consumption, survey finds

The experts that can outsmart optical illusions

Pregnancy may reduce long COVID risk

Scientists uncover novel immune mechanism in wheat tandem kinase

Three University of Virginia Engineering faculty elected as AAAS Fellows

[Press-News.org] Exploring binge eating and binge drinking alcohol comorbidity
Mouse study suggests females are more sensitive to the cooccurrence of binge eating and drinking and identifies a protein that prevents this disease comorbidity in both sexes.