###
Please contact media@sfn.org for full-text PDF.
About JNeurosci
JNeurosci was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors' changing publishing needs, representing breadth of the field and diversity in authorship.
About The Society for Neuroscience
The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 35,000 members in more than 95 countries.
END
Exploring binge eating and binge drinking alcohol comorbidity
Mouse study suggests females are more sensitive to the cooccurrence of binge eating and drinking and identifies a protein that prevents this disease comorbidity in both sexes.
2025-03-31
(Press-News.org) The comorbidity of binge eating and alcohol binge drinking is prevalent and increases the risk of other neuropsychiatric and bodily conditions. However, the mechanisms linking these forms of binge consumption are unclear. To explore the link between binge eating and binge drinking alcohol, Karen Szumlinski, from the University of California, Santa Barbara, and colleagues developed a way to model the disease comorbidity in mice. As reported in their JNeurosci paper, this mouse model led to the discovery that females with a history of binge eating start binge drinking alcohol quicker than males. The researchers also found that females had increased levels of a protein previously associated with comorbid alcohol use disorder and eating disorders called phosphodiesterase 4B (PDE4B). Inhibiting the protein prevented cooccurrence of binging in both sexes of mice. According to the authors, this study supports previous work linking PDE4B to problematic alcohol use and eating disorders and may inform future work investigating whether the protein is an effective treatment target. The authors also emphasize that the behavioral paradigm they developed may be useful for preclinical researchers working to unveil more mechanisms linking binge eating and drinking.
ELSE PRESS RELEASES FROM THIS DATE:
The proportion of harmful substances in particulate matter is much higher than assumed
2025-03-31
People breathing contaminated air over the course of years are at greater risk of developing numerous diseases. This is thought to be due to highly reactive components in particulate matter, which affect biological processes in the body. However, researchers from the University of Basel, Switzerland, have now shown that precisely these components disappear within hours and that previous measurements therefore completely underestimate the quantities in which they are present.
From chronic respiratory problems to cardiovascular diseases, ...
Administration is weakening U.S. research capacity and endangering Americans, nation’s leading scientists warn
2025-03-31
The wellbeing of Americans and the country’s longstanding position as a world leader in science and technology are in jeopardy due to the actions of the Trump administration, approximately 1,900 leading figures in medicine, science, and engineering warn today in an open statement to the American public. The list of signatories includes Nobel Prize winners, deans of medical schools, and national leaders in science and technology.
“For over 80 years, wise investments by the US government have built up the nation’s research enterprise, making it the envy of ...
Trade Tariffs on Canadian Pharmaceuticals— Implications for US Drug Supply and Costs
2025-03-31
About The Study: Although Canada is not the largest supplier of medications to the U.S., tariffs could raise costs and strain supply chains. This study estimates that $3 billion in U.S. pharmaceuticals depend on Canadian manufacturing, with 25% tariffs adding $750 million in cost. Although the Inflation Reduction Act provisions limit cost pass-through to some payers (i.e., Medicare), manufacturers may still adjust production or alter distribution, increasing supply chain fragility.
Corresponding Author: To contact the corresponding author, Mina Tadrous, PharmD, PhD, email mina.tadrous@utoronto.ca.
To access the embargoed study: Visit our For The Media website ...
Cardiovascular Health Among Rural and Urban US Adults— Healthcare, Lifestyle, and Social Factors
2025-03-31
About The Study: This national cross-sectional study found substantial rural-urban disparities in cardiometabolic risk factors and cardiovascular diseases, which were largest among younger adults and almost entirely explained by social risk factors. These findings suggest that efforts to improve socioeconomic conditions in rural communities may be critical to address the rural-urban gap in cardiovascular health.
Corresponding Author: To contact the corresponding author, Rishi K. Wadhera, MD, MPP, MPhil, email rwadhera@bidmc.harvard.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamacardio.2025.0538)
Editor’s ...
Study finds gap between heart disease outcomes in men and women has narrowed over past 20 years
2025-03-31
While the typical image of someone suffering a heart attack might be a man clutching his chest, heart disease is a major problem for women, too. In fact, it’s the leading cause of death among women in the United States, with nearly 45% of the nation’s women over age 20 living with some form of cardiovascular disease.
A new study from heart researchers at Intermountain Health in Salt Lake City shows that while rates of death and other cardiac-related events – like heart attack – are still high for women, the ...
New study links lower proportions of certain sleep stages to brain changes associated with Alzheimer’s disease
2025-03-31
DARIEN, IL — New research reveals that lower proportions of specific sleep stages are associated with reduced brain volume in regions vulnerable to the development of Alzheimer’s disease over time.
Results show that individuals with lower proportions of time spent in slow wave sleep and rapid eye movement sleep had smaller volumes in critical brain regions, particularly the inferior parietal region, which is known to undergo early structural changes in Alzheimer’s disease. The results were adjusted for potential confounders including demographic characteristics, smoking history, alcohol use, hypertension, and coronary heart disease.
“Our findings provide ...
Long-term practice of Transcendental Meditation may reduce both stress and aging
2025-03-31
A collaborative study conducted by researchers at Maharishi International University (MIU), the University of Siegen, and the Uniformed Services University of the Health Sciences reveals that individuals practicing Transcendental Meditation® (TM®) technologies long-term show favorable biological markers of aging and stress. The research compared gene expression, cognitive function (via EEG), and hair glucocorticoids (cortisol and cortisone) in 12-year and 40-year TM groups and non-meditator controls.
“This study provides evidence that long-term practice of TM technologies has a broad range of health benefits at the molecular ...
Delicate balancing act determines how many genome gateways form in cells
2025-03-31
EMBARGOED UNTIL MONDAY, MARCH 31 – 11:00 AM Eastern
The nuclei in our cells are miniature warehouses safeguarding the genetic blueprint for the body’s biologic machinery.
As warehouses go, nuclei are more like libraries than bank vaults. Too many cellular components need access to the genome to lock it down like Fort Knox. Instead, large groupings of more than 1,000 individual protein molecules called nuclear pore complexes (NPCs) pepper the dividing membrane, serving as gateways for materials and messages entering and exiting the nucleus.
While the basic need for this shuttle service is constant, ...
Postpartum hormonal contraceptive use and risk of depression
2025-03-31
About The Study: Hormonal contraceptive initiation postpartum was associated with an instantaneous increased risk of developing depression in this cohort study. The associated risk was higher the earlier it was initiated postpartum, at least for combined oral contraceptives. This finding raises the issue of whether the incidence of depression postpartum is increased by routine hormonal contraceptive initiation after childbirth.
Corresponding Author: To contact the corresponding author, Vibe Gedsø Frokjaer, PhD, email vibe.frokjaer@nru.dk.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2025.2474)
Editor’s ...
CU research poised to change oxygen standards for trauma patients
2025-03-31
When a critically injured patient is admitted to the hospital, how much supplemental oxygen should they receive? New research published this week in JAMA Network Open led by investigators at the University of Colorado School of Medicine suggests it’s often less than the current standard.
“The idea has traditionally been that severe trauma causes stress to patients’ bodies, and we want to deliver as much oxygen as possible to the brain and to vital organs because they are losing blood,” says Adit Ginde, MD, MPH, professor ...
LAST 30 PRESS RELEASES:
Tiny metal figurines from Sardinia's Nuragic civilization in around 1,000 BC reveal extensive ancient Mediterranean metal trading networks
Natural microfibers may degrade differently to synthetic materials under simulated sunlight exposure in freshwater and seawater conditions, with implications for how such pollutants affect aquatic lif
Indian new mums report better postpartum wellbeing when their own mum acts as their primary support - while women whose mother-in-law is the primary caregiver instead report significantly lower overal
Young adult intelligence and education are correlated with socioeconomic status in midlife
Traditional and “existential” wellness vary significantly between US regions
Smartwatches detect early signs of PTSD among those watching coverage of the Oct 7 attacks in Israel
The pandemic may have influenced the trainability of dogs, as reported by their owners
The withdrawal of U.S. funding for tuberculosis could lead to up to 2.2 million additional deaths between 2025 and 2030 inclusive
A ‘universal’ therapy against the seasonal flu? Antibody cocktail targets virus weak spot
Could robots help kids conquer reading anxiety? New study from the Department of Computer Science at UChicago suggests so
UCSB-designed soft robot intubation device could save lives
Burial Site challenges stereotypes of Stone Age women and children
Protein found in the eye and blood significantly associated with cognition scores
USF study reveals how menopause impacts women’s voices – and why it matters
AI salespeople aren’t better than humans… yet
Millions of men could benefit from faster scan to diagnose prostate cancer
Simulations solve centuries-old cosmic mystery – and discover new class of ancient star systems
MIT study explains how a rare gene variant contributes to Alzheimer’s disease
Race, ethnicity, insurance payer, and pediatric cardiac arrest survival
High-intensity exercise and hippocampal integrity in adults with cannabis use disorder
“Brain dial” for consumption found in mice
Lung cancer rewires immune cells in the bone marrow to weaken body’s defenses
Researchers find key to Antarctic ice loss blowing in the north wind
Ten years after the discovery, gravitational waves verify Stephen Hawking's Black Hole Area Theorem
Researchers uncover potential biosignatures on Mars
Built to learn: how early brain structure primes the brain to learn efficiently
Cells use electricity to eliminate their ‘weakest’ neighbours to maintain healthy protective barriers
New motion-compensation approach delivers sharper single-pixel imaging for dynamic scenes
Journal of Psychiatry and Neuroscience now officially part of the Canadian Science Publishing portfolio
What motivates runners? Focusing on the “how” rather than the “why”
[Press-News.org] Exploring binge eating and binge drinking alcohol comorbidityMouse study suggests females are more sensitive to the cooccurrence of binge eating and drinking and identifies a protein that prevents this disease comorbidity in both sexes.