###
Please contact media@sfn.org for full-text PDF.
About JNeurosci
JNeurosci was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors' changing publishing needs, representing breadth of the field and diversity in authorship.
About The Society for Neuroscience
The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 35,000 members in more than 95 countries.
END
Exploring binge eating and binge drinking alcohol comorbidity
Mouse study suggests females are more sensitive to the cooccurrence of binge eating and drinking and identifies a protein that prevents this disease comorbidity in both sexes.
2025-03-31
(Press-News.org) The comorbidity of binge eating and alcohol binge drinking is prevalent and increases the risk of other neuropsychiatric and bodily conditions. However, the mechanisms linking these forms of binge consumption are unclear. To explore the link between binge eating and binge drinking alcohol, Karen Szumlinski, from the University of California, Santa Barbara, and colleagues developed a way to model the disease comorbidity in mice. As reported in their JNeurosci paper, this mouse model led to the discovery that females with a history of binge eating start binge drinking alcohol quicker than males. The researchers also found that females had increased levels of a protein previously associated with comorbid alcohol use disorder and eating disorders called phosphodiesterase 4B (PDE4B). Inhibiting the protein prevented cooccurrence of binging in both sexes of mice. According to the authors, this study supports previous work linking PDE4B to problematic alcohol use and eating disorders and may inform future work investigating whether the protein is an effective treatment target. The authors also emphasize that the behavioral paradigm they developed may be useful for preclinical researchers working to unveil more mechanisms linking binge eating and drinking.
ELSE PRESS RELEASES FROM THIS DATE:
The proportion of harmful substances in particulate matter is much higher than assumed
2025-03-31
People breathing contaminated air over the course of years are at greater risk of developing numerous diseases. This is thought to be due to highly reactive components in particulate matter, which affect biological processes in the body. However, researchers from the University of Basel, Switzerland, have now shown that precisely these components disappear within hours and that previous measurements therefore completely underestimate the quantities in which they are present.
From chronic respiratory problems to cardiovascular diseases, ...
Administration is weakening U.S. research capacity and endangering Americans, nation’s leading scientists warn
2025-03-31
The wellbeing of Americans and the country’s longstanding position as a world leader in science and technology are in jeopardy due to the actions of the Trump administration, approximately 1,900 leading figures in medicine, science, and engineering warn today in an open statement to the American public. The list of signatories includes Nobel Prize winners, deans of medical schools, and national leaders in science and technology.
“For over 80 years, wise investments by the US government have built up the nation’s research enterprise, making it the envy of ...
Trade Tariffs on Canadian Pharmaceuticals— Implications for US Drug Supply and Costs
2025-03-31
About The Study: Although Canada is not the largest supplier of medications to the U.S., tariffs could raise costs and strain supply chains. This study estimates that $3 billion in U.S. pharmaceuticals depend on Canadian manufacturing, with 25% tariffs adding $750 million in cost. Although the Inflation Reduction Act provisions limit cost pass-through to some payers (i.e., Medicare), manufacturers may still adjust production or alter distribution, increasing supply chain fragility.
Corresponding Author: To contact the corresponding author, Mina Tadrous, PharmD, PhD, email mina.tadrous@utoronto.ca.
To access the embargoed study: Visit our For The Media website ...
Cardiovascular Health Among Rural and Urban US Adults— Healthcare, Lifestyle, and Social Factors
2025-03-31
About The Study: This national cross-sectional study found substantial rural-urban disparities in cardiometabolic risk factors and cardiovascular diseases, which were largest among younger adults and almost entirely explained by social risk factors. These findings suggest that efforts to improve socioeconomic conditions in rural communities may be critical to address the rural-urban gap in cardiovascular health.
Corresponding Author: To contact the corresponding author, Rishi K. Wadhera, MD, MPP, MPhil, email rwadhera@bidmc.harvard.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamacardio.2025.0538)
Editor’s ...
Study finds gap between heart disease outcomes in men and women has narrowed over past 20 years
2025-03-31
While the typical image of someone suffering a heart attack might be a man clutching his chest, heart disease is a major problem for women, too. In fact, it’s the leading cause of death among women in the United States, with nearly 45% of the nation’s women over age 20 living with some form of cardiovascular disease.
A new study from heart researchers at Intermountain Health in Salt Lake City shows that while rates of death and other cardiac-related events – like heart attack – are still high for women, the ...
New study links lower proportions of certain sleep stages to brain changes associated with Alzheimer’s disease
2025-03-31
DARIEN, IL — New research reveals that lower proportions of specific sleep stages are associated with reduced brain volume in regions vulnerable to the development of Alzheimer’s disease over time.
Results show that individuals with lower proportions of time spent in slow wave sleep and rapid eye movement sleep had smaller volumes in critical brain regions, particularly the inferior parietal region, which is known to undergo early structural changes in Alzheimer’s disease. The results were adjusted for potential confounders including demographic characteristics, smoking history, alcohol use, hypertension, and coronary heart disease.
“Our findings provide ...
Long-term practice of Transcendental Meditation may reduce both stress and aging
2025-03-31
A collaborative study conducted by researchers at Maharishi International University (MIU), the University of Siegen, and the Uniformed Services University of the Health Sciences reveals that individuals practicing Transcendental Meditation® (TM®) technologies long-term show favorable biological markers of aging and stress. The research compared gene expression, cognitive function (via EEG), and hair glucocorticoids (cortisol and cortisone) in 12-year and 40-year TM groups and non-meditator controls.
“This study provides evidence that long-term practice of TM technologies has a broad range of health benefits at the molecular ...
Delicate balancing act determines how many genome gateways form in cells
2025-03-31
EMBARGOED UNTIL MONDAY, MARCH 31 – 11:00 AM Eastern
The nuclei in our cells are miniature warehouses safeguarding the genetic blueprint for the body’s biologic machinery.
As warehouses go, nuclei are more like libraries than bank vaults. Too many cellular components need access to the genome to lock it down like Fort Knox. Instead, large groupings of more than 1,000 individual protein molecules called nuclear pore complexes (NPCs) pepper the dividing membrane, serving as gateways for materials and messages entering and exiting the nucleus.
While the basic need for this shuttle service is constant, ...
Postpartum hormonal contraceptive use and risk of depression
2025-03-31
About The Study: Hormonal contraceptive initiation postpartum was associated with an instantaneous increased risk of developing depression in this cohort study. The associated risk was higher the earlier it was initiated postpartum, at least for combined oral contraceptives. This finding raises the issue of whether the incidence of depression postpartum is increased by routine hormonal contraceptive initiation after childbirth.
Corresponding Author: To contact the corresponding author, Vibe Gedsø Frokjaer, PhD, email vibe.frokjaer@nru.dk.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2025.2474)
Editor’s ...
CU research poised to change oxygen standards for trauma patients
2025-03-31
When a critically injured patient is admitted to the hospital, how much supplemental oxygen should they receive? New research published this week in JAMA Network Open led by investigators at the University of Colorado School of Medicine suggests it’s often less than the current standard.
“The idea has traditionally been that severe trauma causes stress to patients’ bodies, and we want to deliver as much oxygen as possible to the brain and to vital organs because they are losing blood,” says Adit Ginde, MD, MPH, professor ...
LAST 30 PRESS RELEASES:
We should talk more at school: Researchers call for more conversation-rich learning as AI spreads
LHAASO uncovers mystery of cosmic ray "knee" formation
The simulated Milky Way: 100 billion stars using 7 million CPU cores
Brain waves’ analog organization of cortex enables cognition and consciousness, MIT professor proposes at SfN
Low-glutamate diet linked to brain changes and migraine relief in veterans with Gulf War Illness
AMP 2025 press materials available
New genetic test targets elusive cause of rare movement disorder
A fast and high-precision satellite-ground synchronization technology in satellite beam hopping communication
What can polymers teach us about curing Alzheimer's disease?
Lead-free alternative discovered for essential electronics component
BioCompNet: a deep learning workflow enabling automated body composition analysis toward precision management of cardiometabolic disorders
Skin cancer cluster found in 15 Pennsylvania counties with or near farmland
For platforms using gig workers, bonuses can be a double-edged sword
Chang'e-6 samples reveal first evidence of impact-formed hematite and maghemite on the Moon
New study reveals key role of inflammasome in male-biased periodontitis
MD Anderson publicly launches $2.5 billion philanthropic campaign, Only Possible Here, The Campaign to End Cancer
Donors enable record pool of TPDA Awards to Neuroscience 2025
Society for Neuroscience announces Gold Sponsors of Neuroscience 2025
The world’s oldest RNA extracted from woolly mammoth
Research alert: When life imitates art: Google searches for anxiety drug spike during run of The White Lotus TV show
Reading a quantum clock costs more energy than running it, study finds
Early MMR vaccine adoption during the 2025 Texas measles outbreak
Traces of bacteria inside brain tumors may affect tumor behavior
Hypertension affects the brain much earlier than expected
Nonlinear association between systemic immune-inflammation index and in-hospital mortality in critically ill patients with chronic obstructive pulmonary disease and atrial fibrillation: a cross-sectio
Drift logs destroying intertidal ecosystems
New test could speed detection of three serious regional fungal infections
New research on AI as a diagnostic tool to be featured at AMP 2025
New test could allow for more accurate Lyme disease diagnosis
New genetic tool reveals chromosome changes linked to pregnancy loss
[Press-News.org] Exploring binge eating and binge drinking alcohol comorbidityMouse study suggests females are more sensitive to the cooccurrence of binge eating and drinking and identifies a protein that prevents this disease comorbidity in both sexes.