GLP-1RA and SGLT2i medications for type 2 diabetes and Alzheimer disease and related dementias

JAMA Neurology

2025-04-07

(Press-News.org) About The Study: In people with type 2 diabetes, both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) were statistically significantly associated with decreased risk of Alzheimer disease and related dementias compared with other glucose-lowering drugs, and no difference was observed between both drugs.

Corresponding Author: To contact the corresponding author, Jingchuan Guo, MD, PhD, email guoj1@ufl.edu.

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(doi:10.1001/jamaneurol.2025.0353)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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GLP-1RA and SGLT2i medications for type 2 diabetes and Alzheimer disease and related dementias

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