Opioid cap laws and opioid prescriptions after total joint replacements in older adults

JAMA Network Open

2025-04-09

(Press-News.org) About The Study: The findings of this study suggest that the New York opioid restriction law was associated with reductions in opioid quantities in the immediate total joint replacement postoperative period. Additional refinements may further reduce opioid prescribing in New York, and these findings may serve as a foundation for refining laws in other states that may not achieve their intended targets or have not implemented similar laws.

Corresponding Author: To contact the corresponding author, Caroline P. Thirukumaran, MBBS, MHA, PhD, email caroline.thirukumaran@northwestern.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.4448)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.4448?guestAccessKey=c0957767-f5eb-4d6d-88a4-15c747418b57&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=040925

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Potential Alzheimer’s disease therapeutic target identified in brain immune cells

2025-04-09

Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now. In a paper published in Nature, researchers from Mass General Brigham used preclinical models to uncover Tim-3’s role in microglia, the brain's resident immune cells, and have identified it as a promising therapeutic target for Alzheimer’s disease. “Immune checkpoint inhibitors have revolutionized cancer immunotherapy, and it is exciting that we might be able to repurpose them to treat Alzheimer’s disease,” said senior author Vijay Kuchroo, ...

New gene editing tool shows promise for treating diseases with multiple mutations

2025-04-09

Investigators from Mass General Brigham and Beth Israel Deaconess Medical Center have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations. The system can be formulated completely as RNA, dramatically simplifying delivery logistics compared to traditional systems that use both RNA and DNA. By inserting an entire gene, the tool offers a one-and-done approach that overcomes hurdles from CRISPR gene editing technology—which is programmed to correct individual mutations—offering a promising step forward for gene therapy. Results are published in Nature. “CRISPR ...

Longest known seafaring venture 8,500 years ago brings hunter-gatherers to Malta before early farmers

2025-04-09

Seafaring hunter-gatherers were accessing remote, small islands such as Malta thousands of years before the arrival of the first farmers, a new international study has found. Published in Nature, the research team – led by Professor Eleanor Scerri of the Max Planck Institute of Geoanthropology (MPI-GEA) and the University of Malta – found hunter-gatherers were crossing at least 100km of open water to reach the Mediterranean island of Malta 8,500 years ago, a thousand years before the arrival of agricultural practises. This ...

How human cells repair damaged DNA

2025-04-09

The DNA of human cells consists of a sequence of about 3.1 billion building blocks. Cells go to great lengths to maintain the integrity of this vast store of information. They constantly untangle knots in the DNA strand and create new chemical bonds when a strand of DNA breaks somewhere in the nucleus. “When people read about repairing genetic material, they often think of it being in response to exposure to toxins or radiation,” says Jacob Corn, Professor of Genome Biology at ETH Zurich. However, repair mechanisms not only defend against external threats; they also play a crucial role in helping cells survive the challenges they ...

Your skin is breathing. New wearable device can measure it.

2025-04-09

Northwestern University researchers have developed the first wearable device for measuring gases emitted from and absorbed by the skin. By analyzing these gases, the device offers an entirely new way to assess skin health, including monitoring wounds, detecting skin infections, tracking hydration levels, quantifying exposure to harmful environmental chemicals and more. The new technology comprises a collection of sensors that precisely measure changes in temperature, water vapor, carbon dioxide (CO2) and volatile organic compounds (VOCs), which each give valuable ...

Serendipitous discovery could lead to more efficient catalysts

2025-04-09

PULLMAN, Wash. – Preparing catalysts by sending hot, steamy car exhaust over them could improve their efficiency and reduce the amount of rare and expensive metals required in vehicle catalytic converters and many other emission control and industrial processes. Reporting in the journal, Nature, an international team of researchers found that the hot car exhaust containing nitrogen oxides and carbon monoxide caused a previously unknown reaction that, used proactively, can significantly improve catalytic activity. Catalysts are substances that increase the rate of chemical reactions. The researchers found that hot exhaust encouraged ceria particles, one of the components of the ...

Engineering smart delivery for gene editors

2025-04-09

Overcoming Delivery Challenges in Gene Editing Modern genome editing techniques, including CRISPR systems, hold great potential for treating genetic diseases. However, delivering these molecular tools reliably to their target cells remains a significant challenge. “Previous viral and non-viral delivery systems such as adeno-associated viruses (AAVs), lipid nanoparticles (LNPs), and other virus-like particles (VLPs), have been valuable but face limitations,” says Dr. Dong-Jiunn Jeffery Truong, last author ...

Six ape genomes sequenced telomere-to-telomere

2025-04-09

Comprehensive reference genomes have now been assembled for six ape species: siamang (a Southeast Asian gibbon), Sumatran orangutan, Bornean orangutan, gorilla, bonobo and chimpanzee. Areas of their genomes previously inaccessible because of structural complexity have now mostly been resolved. The resource is already lending itself to comparative studies that offer new insights into human and ape evolution, and into what underlies the functional differences among these species. A report on how the telomere-to-telomere ape genome references were developed, and what scientists are learning from it, appears in the April 9 edition ...

Hubble Space telescope unveils the first images of ongoing star cluster mergers near the center of dwarf galaxies

2025-04-09

A new study reports the first direct observation of merging star clusters in the nuclear region of dwarf galaxies. This detection confirms the feasibility of this formation route for nuclei in dwarf galaxies, which has long been debated. The study was published in Nature science journal, and led by Postdoctoral Researcher Mélina Poulain from the University of Oulu, Finland. Dwarf galaxies are the most abundant type of galaxies that populate the Universe. Composed of 100 times fewer stars than the ...

‘Sugar’ signatures help identify and classify pancreatic cancer cell subtypes

2025-04-09

GRAND RAPIDS, Mich. (April 9, 2025) — Van Andel Institute scientists and collaborators have developed a new method for identifying and classifying pancreatic cancer cell subtypes based on sugars found on the outside of cancer cells. These sugars, called glycans, help cells recognize and communicate with each other. They also act as a cellular “signature,” with each subtype of pancreatic cancer cell possessing a different composition of glycans. The new method, multiplexed glycan immunofluorescence, combines ...

Opioid cap laws and opioid prescriptions after total joint replacements in older adults

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: