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Moffitt-led international study finds new drug delivery system effective against rare eye cancer

Clinical trial finds that a focused approach to treating liver tumors may extend lives of patients with uveal melanoma

2025-04-10
(Press-News.org) TAMPA, Fla. (Apr. 10, 2025) — A multi-institutional study led by Moffitt Cancer Center found that percutaneous hepatic perfusion using a melphalan hepatic delivery system may help patients with a rare eye cancer that has spread to their liver. This disease, known as metastatic uveal melanoma, is traditionally very hard to treat and usually has poor outcomes.

The phase 3 FOCUS trial, published in the Annals of Surgical Oncology, compared two treatments for metastatic uveal melanoma. One group of patients received the melphalan hepatic delivery system treatment, while the other group received standard of care treatment. Patients treated with the melphalan hepatic delivery system experienced significantly improved outcomes than those receiving alternative care. The median progression-free survival for these patients was 9.1 months, compared with 3.3 months for those on standard treatments.

The objective response rate was 27.5%, nearly three times the 9.4% observed in the comparison group. The disease control rate also substantially increased from 46.9% to 80.0%. Patients treated with the melphalan hepatic delivery system lived a median of 18.5 months, compared with 14.5 months for those receiving other forms of care. Although there were some side effects, mostly related to blood cell counts, these were treated with standard care as an outpatient and mostly resolved with observation alone.

“This new treatment gives hope to patients with this historically tough-to-treat cancer,” said Jonathan Zager, M.D., surgical oncologist in the Cutaneous Oncology Department at Moffitt and lead author of the study. “This is the second publication in Annals of Surgical Oncology on the results of the FOCUS trial and definitely shows that treatment with the melphalan hepatic delivery system can help control the cancer in the liver. The treatment provides an option that does not interfere with their quality of life and gives patients a chance at longer survival.”

The melphalan hepatic delivery system treatment was approved by the U.S. Food and Drug Administration in August 2023 based on the phase 3 trial results. Unlike regular chemotherapy, this treatment delivers a high dose of the drug directly into the liver, which is isolated with a series of catheters and balloons via percutaneous insertions. The chemotherapy is filtered out before it gets introduced to the rest of the body. This targeted approach helps reduce harmful side effects in the rest of the body. More research is planned to test the benefits of the melphalan hepatic delivery system. Studies will also look at combining this treatment with other new therapies.

The FOCUS trial is sponsored by Delcath Systems, Inc.

About Moffitt Cancer Center
Moffitt is dedicated to one lifesaving mission: to contribute to the prevention and cure of cancer. The Tampa-based facility is one of only 57 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt’s scientific excellence, multidisciplinary research, and robust training and education. Moffitt’s expert nursing staff is recognized by the American Nurses Credentialing Center with Magnet® status, its highest distinction. For more information, call 1-888-MOFFITT (1-888-663-3488), visit MOFFITT.org, and follow the momentum on Facebook, Twitter, Instagram and YouTube.

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[Press-News.org] Moffitt-led international study finds new drug delivery system effective against rare eye cancer
Clinical trial finds that a focused approach to treating liver tumors may extend lives of patients with uveal melanoma