Effectiveness and safety of RSV vaccine for U.S. adults age 60 or older

JAMA Network Open

2025-05-09

(Press-News.org) About The Study: Vaccine effectiveness (VE) for the respiratory syncytial virus (RSV) protein subunit vaccine in this case-control study was similar to the VE in clinical trials. The VE for immunocompromised patients was mildly (overall) to moderately (for stem cell transplant recipients) diminished. Risk of immune thrombocytopenic purpura after vaccination was not elevated, but the risk of Guilain-Barré syndrome was statistically significantly elevated in patients who received the RSVPreF vaccine but not in those who received RSVPreF+AS01 vaccine, although the risk was small. These observations should inform clinicians’ choices and patient instructions.

Corresponding Author: To contact the corresponding author, Pamela B. Davis, MD, PhD, email pbd@case.edu.

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(doi:10.1001/jamanetworkopen.2025.8322)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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[Press-News.org] Effectiveness and safety of RSV vaccine for U.S. adults age 60 or older
JAMA Network Open

Effectiveness and safety of RSV vaccine for U.S. adults age 60 or older

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