(Press-News.org) Belgrade, Serbia – 17 May 2025. An artificial intelligence-enabled electrocardiogram-based algorithm performed well in the early detection of heart failure among healthcare-seeking individuals in Kenya, according to late-breaking research presented today at Heart Failure 2025,1 a scientific congress of the European Society of Cardiology (ESC).
Heart failure is highly prevalent in Sub-Saharan Africa, where patients are often younger and face worse outcomes than in high-income countries.2 Explaining the rationale for the current study, presenter Dr. Ambarish Pandey from the University of Texas Southwestern Medical Center, Dallas, Texas, USA, said: “Early detection of left ventricular systolic dysfunction (LVSD) represents an important strategy to identify patients who are likely to develop heart failure and yet there is little access to echocardiography, the gold standard method to diagnose LVSD, in resource-limited settings. We conducted a study in Kenya to determine whether LVSD could be assessed from an electrocardiogram (ECG) using validated artificial intelligence (AI)-based software3 as a potential scalable approach to screen large populations.”
This prospective cross-sectional multicentre screening study included adult patients who attended eight healthcare facilities in Kenya. Cardiovascular risk factor burden was assessed with a classification of high cardiovascular risk based on prior cardiovascular disease (CVD) or Framingham Risk Score (FRS) >10%. All participants had a 12-lead ECG and the prevalence of LVSD (left ventricular ejection fraction <40%) was assessed by the AI-ECG algorithm (AiTiALVSD; Medical AI Co, Seoul, Republic of Korea). The AI-ECG algorithm predicted LVSD probability using a pre-established threshold of >0.097 to define high risk. A subset of participants had LVSD assessments by both the AI-ECG algorithm and echocardiography to evaluate the AI-ECG model’s performance.
The evaluable study cohort included 5,992 participants who had a mean age of 55 years, two-thirds were female (66%) and 65% were classified as being at high cardiovascular risk.
The prevalence of LVSD using the AI-ECG algorithm was 18.3%, with a higher prevalence among those with high Framingham risk score (FRS, 22.9%) or existing CVD (32.0%) than those with low FRS (9.9%).
In 1,444 participants with paired assessments, echocardiography-confirmed LVSD was present in 14.1%. The AI-ECG algorithm demonstrated excellent performance metrics compared with echocardiography: sensitivity was 95.6%, specificity was 79.4% and the negative predictive value was 99.1%. “Our study shows the potential utility of AI-ECG algorithms as a relatively low cost and scalable tool for screening for heart disease including heart failure in at-risk populations in resource-limited societies,” added Dr. Bernard Samia, senior author and President of the Kenya Cardiac Society.
Dr. Pandey concluded: “It was striking that the AI-ECG algorithm identified LVSD in almost 1 in 5 individuals, highlighting the large population at risk of heart failure. Given that the AI-ECG algorithm performed well against the gold standard method, we would now like to conduct larger screening studies across several countries in Africa. It will also be important to investigate whether identification of LVSD leads to greater use of evidence-based therapies.”
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Funding: The study was funded by research grant support from Astra Zeneca and in-kind support from Tricog Health.
Disclosures: Dr. Pandey reports research support from the National Institute on Minority Health and Disparities (R01MD017529), the National Institute of Heart, Lung, and Blood Institute (R21HL169708), American Heart Association, Ultromics, Anumana, SC Pharmaceuticals, SQ Innovation, Astra Zeneca and Roche Diagnostics. He serves as a consultant for and/or received honoraria outside of the present study as an advisor/consultant for Northwestern University, Tricog Health Inc, Lilly USA, Rivus, Cytokinetics, Roche Diagnostics, Sarfez Therapeutics, Edwards Lifesciences, Merck, Bayer, Anumana, Novo Nordisk, Alleviant, Pfizer, Abbott, iRhythm, Axon Therapies, Kilele Health, Acorai, Ultromics, Kardigan, Novartis, Idorsia Pharma, and Science37; and has also served as a consultant for Palomarin Inc. with stocks compensation. Dr. Samia has no disclosures to report.
References and notes:
1‘Implementing an AI-ECG based algorithm to screen for left ventricular dysfunction in Kenya: a prospective cohort study’ will be presented during Late-breaking science: diagnostic methods and assessment on 17 May from 13:45 to 14:45 CET in Room 1.
2Siddikatou D, Linwa EMM, Ndobo V, et al. Heart failure outcomes in Sub-Saharan Africa: a scoping review of recent studies conducted after the 2022 AHA/ACC/HFSA guideline release. BMC Cardiovasc Disord. 2025;25:302.
3Kwon JM, Kim KH, Jeon KH, et al. Development and validation of deep-learning algorithm for electrocardiography-based heart failure identification. Korean Circ J. 2019;49:629–639.
About the European Society of Cardiology
The ESC brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people to live longer, healthier lives.
About Heart Failure 2025
Heart Failure is the annual congress of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). #HeartFailure2025
About the Heart Failure Association
The Heart Failure Association (HFA) is a branch of the European Society of Cardiology (ESC). Its aim is to improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research.
Information for journalists about registration for Heart Failure 2025
Heart Failure 2025 takes place from 17 to 20 May at the Sava Centar, Belgrade, Serbia and online. Explore the scientific programme
Free registration applies to accredited press.
Credentials: A valid press card or appropriate letter of assignment with proof of three recent published articles. Read the ESC media and embargo policy.
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END
AI-enabled ECG algorithm performs well in the early detection of heart failure in Kenya
2025-05-17
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