Weight loss in midlife, chronic disease incidence, and all-cause mortality during extended follow-up

JAMA Network Open

2025-05-27

(Press-News.org) About The Study: In this study, conducted when surgical and pharmacological weight-loss interventions were nearly nonexistent, sustained midlife weight loss compared with persistent overweight was associated with a decreased risk of chronic diseases beyond type 2 diabetes and decreased all-cause mortality.

Corresponding Author: To contact the corresponding author, Timo E. Strandberg, MD, PhD, email timo.strandberg@helsinki.fi.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.11825)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.11825?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=052725

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Patient-delivered continuous care for weight loss maintenance

2025-05-27

About The Study: In this trial, patient-delivered lifestyle intervention (mentor interventionists plus peer support) yielded significantly better weight loss maintenance and cardiovascular risk outcomes compared with standard-of-care treatment delivered by professionals. Future research may examine the effectiveness of this novel treatment approach in community and clinical settings. Corresponding Author: To contact the corresponding author, Tricia M. Leahey, PhD, email tricia.leahey@uconn.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2025.1345) Editor’s ...

HIV drug can improve vision in patients with common diabetes complication, clinical trial suggests

2025-05-27

An inexpensive, long-approved HIV drug can improve vision in patients with a blinding complication of diabetes more effectively and a much lower cost than many existing treatments, an initial clinical trial suggests. Further, the drug is taken orally, potentially offering patients an alternative to monthly injections directly into their eyes. The drug, lamivudine, could represent an important new option for millions of patients with diabetic macular edema (DME), a condition which causes fluid to build up in the retina of the eye. ...

New fuel cell could enable electric aviation

2025-05-27

Batteries are nearing their limits in terms of how much power they can store for a given weight. That’s a serious obstacle for energy innovation and the search for new ways to power airplanes, trains, and ships. Now, researchers at MIT and elsewhere have come up with a solution that could help electrify these transportation systems. Instead of a battery, the new concept is a kind of fuel cell — which is similar to a battery but can be quickly refueled rather than recharged. In this case, the fuel is liquid sodium metal, an inexpensive and widely available commodity. The other side of the cell is just ordinary air, which serves as ...

New clinical practice guideline for the surgical management of chronic rhinosinusitis in adults

2025-05-27

ALEXANDRIA, VA —The American Academy of Otolaryngology–Head and Neck Surgery Foundation (AAO-HNSF) published the new Clinical Practice Guideline (CPG): Surgical Management of Chronic Rhinosinusitis today in Otolaryngology–Head and Neck Surgery. Chronic rhinosinusitis (CRS) affects 11.6% of adults and prompts 4.1 million annual ambulatory visits. "Chronic rhinosinusitis doesn't just affect the nose—it can influence a person's general life. Patients can struggle with poor sleep, ...

Newly discovered ‘molecular fingerprints’ could transform diabetes treatment and diagnosis

2025-05-27

Scientists have unearthed surprising details about how our bodies handle insulin – the hormone that plays a crucial role in regulating blood sugar and developing diabetes. The discovery could lead to better treatment of type 2 diabetes and earlier diagnosis, potentially even before the disease develops. In a new paper in the scientific journal Cell, researchers from the University of Copenhagen found that all individuals have unique and varying degrees of insulin resistance at the molecular level. The discovery of this ‘molecular fingerprint’ for insulin sensitivity challenges the traditional binary classification ...

MicroRNA-124-3p and brain-derived neurotrophic factor in rat spinal cord injury: Inverse expression pattern

2025-05-27

Spinal cord injury (SCI) significantly impacts the central nervous system, with limited effective treatments available. Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal growth, survival, and regeneration after SCI. MicroRNAs, particularly miR-124-3p, have been implicated in SCI pathophysiology. However, the relationship between miR-124-3p and BDNF in the context of SCI remains unclear. This study aimed to investigate the correlation between miR-124-3p expression and BDNF levels in a rat model of spinal cord injury and to assess how the timing of injury affects this relationship. Methods This study included 72 male Wistar rats divided ...

Oldest whale bone tools discovered

2025-05-27

Humans were making tools from whale bones as far back as 20,000 years ago, according to a study conducted by scientists from the Institute of Environmental Science and Technology of the Universitat Autònoma de Barcelona (ICTA-UAB), the French National Centre for Scientific Research (CNRS), and the University of British Columbia. This discovery broadens our understanding of early human use of whale remains and offers valuable insight into the marine ecology of the time. Whales, the largest animals on Earth, were an important ...

Germinated flours in breadmaking: Striking a balance between nutrition and quality

2025-05-27

A recent study explores the potential of germinated flours as functional ingredients in breadmaking, highlighting both their nutritional benefits and their technological challenges. The growing demand for healthier foods has inspired the scientific community to reexamine traditional ingredients through a modern lens. One such example is germinated flours, which are emerging as a promising alternative for enhancing the nutritional profile of bread, one of the most widely consumed foods worldwide. At the Food Science and Technology Laboratory at ESPOL, researchers comprehensively reviewed the latest findings on the use of germinated ...

Timely initiation of statin therapy for diabetes shown to dramatically reduce risk of heart attack and stroke

2025-05-27

Taking a statin medication is an effective, safe, and low-cost way to lower cholesterol and reduce risk of cardiovascular events. Despite clinicians recommending that many patients with diabetes take statins, nearly one-fifth of them opt to delay treatment. In a new study, researchers from Mass General Brigham found that patients who started statin therapy right away reduced the rate of heart attack and stroke by one third compared to those who chose to delay taking the medication. The results, which can help guide decision-making conversations between clinicians and their patients, are published in the Journal of the ...

University of Houston awarded $3M to launch cancer biomarker facility for immunotherapy research

2025-05-27

Key takeaway: The new University of Houston Cancer Immunotherapy Biomarker Core facility will accelerate biomarker discovery, improve immunotherapy targeting and expand research capacity across Texas — enhancing the state's competitiveness in cancer research and ultimately improving patient outcomes. HOUSTON, May 27 -- As part of a $93 million grant package, the Cancer Prevention and Research Institute of Texas, known for funding groundbreaking projects, has awarded the University of Houston $3 million to set up a Cancer Immunotherapy Biomarker Core. This state-of-the-art facility will offer researchers in Texas ...

Weight loss in midlife, chronic disease incidence, and all-cause mortality during extended follow-up

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: