Weight loss in midlife, chronic disease incidence, and all-cause mortality during extended follow-up

JAMA Network Open

2025-05-27

(Press-News.org) About The Study: In this study, conducted when surgical and pharmacological weight-loss interventions were nearly nonexistent, sustained midlife weight loss compared with persistent overweight was associated with a decreased risk of chronic diseases beyond type 2 diabetes and decreased all-cause mortality.

Corresponding Author: To contact the corresponding author, Timo E. Strandberg, MD, PhD, email timo.strandberg@helsinki.fi.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.11825)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Weight loss in midlife, chronic disease incidence, and all-cause mortality during extended follow-up

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