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After stroke, admission to designated stroke center hospitals associated with reduced risk of death

( Patients who had an ischemic stroke and were admitted to hospitals designated as primary stroke centers had a modestly lower risk of death at 30 days, compared to patients who were admitted to non-designated hospitals, according to a study in the January 26 issue of JAMA.

Stroke is the leading cause of serious long-term disability and the third leading cause of death in the United States. Responding to the need for improvements in acute stroke care, the Brain Attack Coalition (BAC) published recommendations for the establishment of primary stroke centers in 2000, and in 2003 the Joint Commission began certifying stroke centers based on these recommendations, according to background information in the article. Now, nearly 700 of the 5,000 acute care hospitals in the United States are Joint Commission-certified stroke centers, with some states establishing their own designation programs using the BAC core criteria. "Despite widespread support for the stroke center concept, there is limited empirical evidence demonstrating that admission to a stroke center is associated with lower mortality," the authors write.

Ying Xian, M.D., Ph.D., of the Duke Clinical Research Institute, Durham, N.C., and colleagues conducted a study to evaluate the association between admission to stroke centers for acute ischemic stroke and the rate of death. Using data from the New York Statewide Planning and Research Cooperative System, the researchers compared mortality for patients admitted with acute ischemic stroke (n = 30,947) between 2005 and 2006 at designated stroke centers and nondesignated hospitals. Patients were followed up for mortality for 1 year after hospitalization through 2007. To assess whether the findings were specific to stroke, the researchers also compared mortality for patients admitted with gastrointestinal hemorrhage (n = 39,409) or heart attack (n = 40,024) at designated stroke centers and nondesignated hospitals.

Among the patients with acute ischemic stroke, 49.4 percent (n = 15,297) were admitted to designated stroke centers (n=104) and 50.6 percent to non-designated hospitals. The overall 30-day all-cause mortality rate was 10.1 percent for patients admitted to designated stroke centers and 12.5 percent for patients admitted to nondesignated hospitals, with analysis indicating that admission to a designated stroke center hospital was associated with a 2.5 percent absolute reduction in 30-day all-cause mortality. Use of thrombolytic therapy (dissolving blood clots) was 4.8 percent for patients admitted at designated stroke centers and 1.7 percent for patients admitted at nondesignated hospitals (adjusted difference in use, 2.2 percent). Among patients surviving to hospital discharge, there was no difference in rates of 30-day all-cause readmission and discharge to a skilled nursing facility.

"Differences in mortality also were observed at 1-day, 7-day, and 1-year follow-up. The outcome differences were specific for stroke, as stroke centers and nondesignated hospitals had similar 30-day all-cause mortality rates among those with gastrointestinal hemorrhage or acute myocardial infarction," the authors write.

"Even though the differences in outcomes between stroke centers and nondesignated hospitals were modest, our study suggests that the implementation and establishment of a BAC-recommended stroke system of care was associated with improvement in some outcomes for patients with acute ischemic stroke."

(JAMA. 2011;305[4]:373-380. Available pre-embargo to the media at

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Preventing Death One Stroke at a Time

In an accompanying editorial, Mark J. Alberts, M.D., of the Stroke Program, Northwestern University School of Medicine, Chicago, comments on the future of acute stroke care.

"A multitiered system of stroke care is developing, with the comprehensive stroke center (CSC) at the top of the pyramid, the primary stroke center (PSC) in the middle, and the acute stroke ready hospital (ASRH) at the base. Within a geographical region, a small number of CSCs would provide care for patients with the most complicated stroke cases; a larger number of PSCs would provide care for the patients with typical, uncomplicated cases; and the ASRH would provide initial screening and triage and begin acute care for patients in a rural, small urban, or suburban setting. Emergency medical services personnel would perform initial screening and triage and would transport patients with a clearly defined stroke to the closest stroke center facility. Using telemedicine technologies, hospital personnel could communicate and transfer patients to the facility with the most appropriate level of care. Many states and guidelines now support and even mandate the diversion of patients suspected of having a stroke to the nearest stroke center facility."

(JAMA. 2011;305[4]:408-409. Available pre-embargo to the media at

Editor's Note: Please see the article for additional information, including financial disclosures, funding and support, etc.

To contact Ying Xian, M.D., Ph.D., call Melissa Schwarting at 919-660-1303 or email To contact editorial author Mark J. Alberts, M.D., call Marla Paul at 312-503-8928 or email

###For More Information: Contact the JAMA/Archives Media Relations Department at 312-464-JAMA or email:


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[] After stroke, admission to designated stroke center hospitals associated with reduced risk of death