PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Possible new approach to treating a life-threatening blood disorder

2011-01-26
(Press-News.org) Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease of the blood system. The condition is caused by the presence of ultralarge multimers of the protein von Willebrand factor, which promote the formation of blood clots (thrombi) in small blood vessels throughout the body. Current treatments are protracted and associated with complications. However, a team of researchers, led by José López, at the Puget Sound Blood Center, Seattle, has generated data in mice that suggest that the drug N-acetylcysteine (NAC), which is FDA approved as a treatment for chronic obstructive lung disease and as an antidote for toxicity due to acetaminophen (paracetamol), might provide a rapid and effective treatment for patients with TTP through its ability to decrease the size of von Willebrand factor multimers.

In an accompanying commentary, Michael Berndt and Robert Andrews, concur with the conclusions of López and colleagues, although they caution that there are a number of caveats to the view that NAC could be used to treat patents with TTP.

INFORMATION:

TITLE: N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice

AUTHOR CONTACT:
José A. López
Puget Sound Blood Center, Seattle, Washington, USA.
Phone: 206.398.5930; Fax: 206.587.6056; E-mail: josel@psbcresearch.org.

View this article at: http://www.jci.org/articles/view/41062?key=f24412516a0e75fcdeae

ACCOMPANYING COMMENTARY
TITLE: Thrombotic thrombocytopenic purpura: reducing the risk?

AUTHOR CONTACT:
Michael C. Berndt
Dublin City University, and Royal College of Surgeons in Ireland, Dublin, Ireland.
Phone: 353.1.7007658; Fax: 353.1.7006558; E-mail: michael.berndt@dcu.ie.

View this article at: http://www.jci.org/articles/view/46091?key=72ff692cf01de9590c43

END



ELSE PRESS RELEASES FROM THIS DATE:

JCI table of contents: Jan. 25, 2011

2011-01-26
EDITOR'S PICK: Possible new approach to treating a life-threatening blood disorder Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease of the blood system. The condition is caused by the presence of ultralarge multimers of the protein von Willebrand factor, which promote the formation of blood clots (thrombi) in small blood vessels throughout the body. Current treatments are protracted and associated with complications. However, a team of researchers, led by José López, at the Puget Sound Blood Center, Seattle, has generated data in mice that suggest ...

After stroke, admission to designated stroke center hospitals associated with reduced risk of death

2011-01-26
Patients who had an ischemic stroke and were admitted to hospitals designated as primary stroke centers had a modestly lower risk of death at 30 days, compared to patients who were admitted to non-designated hospitals, according to a study in the January 26 issue of JAMA. Stroke is the leading cause of serious long-term disability and the third leading cause of death in the United States. Responding to the need for improvements in acute stroke care, the Brain Attack Coalition (BAC) published recommendations for the establishment of primary stroke centers in 2000, and ...

Occurrence of stroke after coronary artery bypass graft surgery appears to be decreasing

2011-01-26
An analysis of data on more than 45,000 patients who underwent coronary artery bypass graft (CABG) surgery at an academic medical center over the past 30 years finds that the occurrence of stroke after CABG has declined, despite an increase in risk profiles of patients, according to a study in the January 26 issue of JAMA. Stroke is a devastating and potentially preventable complication of CABG surgery. Because it increasingly is being reserved for elderly patients with extensive coronary disease and co-existing conditions, prevalence of stroke after CABG is likely to ...

Cholera vaccination beneficial, post-outbreak

2011-01-26
Cholera vaccination beneficial, post-outbreak Researchers newly report evidence that vaccination against cholera can be beneficial even after an outbreak has begun. Rita Reyburn, Dr. Lorenz von Seidlein, Dr. John Clemens and colleagues at the International Vaccine Institute (IVI) in Seoul, Korea analyze the impact that vaccination could have had on recent outbreaks around the globe in "The case for reactive mass oral cholera vaccinations", and Drs. Dang Duc Anh and Anna Lena Lopez and colleagues at IVI and in Vietnam report on the impact of such "reactive" use of vaccine ...

Study: Get thee to a stroke center

2011-01-26
Hospitals with designated stroke centers are associated with up to 20 percent higher survival rate for patients with ischemic stroke and significantly greater use of acute stroke therapy. That is the conclusion of a study appearing today in the Journal of the American Medical Association which compares treatment and outcomes in stroke care between hospitals in New York State. "The basic premise of stroke centers and stroke care – that coordinated care delivered around a specific disease can likely improve outcomes – is widely accepted," said University of Rochester ...

Report examines life expectancy in US and other high-income nations

2011-01-26
Over the last 25 years, life expectancy in the U.S. has been rising at a slower rate than in many other high-income countries, such as Japan and Australia, despite our spending more on health care than any other nation. EXPLAINING DIVERGENT LEVELS OF LONGEVITY IN HIGH-INCOME COUNTRIES, a new report from the National Research Council, identifies factors that contribute to the U.S. shortfall in life expectancy. ###Reporters who wish to obtain copies should contact the Office of News and Public Information at 202-334-2138 or e-mail news@nas.edu. Advance copies will be available ...

Protection of pregnant women against malaria still inadequate

2011-01-26
A study published today in The Lancet Infectious Diseases finds that methods to protect pregnant women from malaria are still underutilised in sub-Saharan Africa (SSA). A review of national control strategies by a team of international researchers, led by the Malaria in Pregnancy Consortium and funded by the Consortium and the Wellcome Trust, has concluded that despite major efforts, coverage is still inadequate in many areas and needs to be scaled up. Malaria infection in pregnancy can lead to devastating consequences for both mother and child. The World Health Organization's ...

Fluorescent color of coral larvae predicts whether they'll settle or swim

Fluorescent color of coral larvae predicts whether theyll settle or swim
2011-01-26
AUSTIN, Texas—Young staghorn coral that fluoresce redder are less likely to settle and develop into coral polyps than their greener peers, University of Texas at Austin biologists have discovered. The finding may help scientists monitor how corals adapt to global warming because the less likely coral larvae are to settle, the more likely they will disperse from their reef of origin. "By simply looking at the color of a larval population, we may soon be able to say which larvae are going to be long-range dispersers and which will be short-range dispersers," says Mikhail ...

Star performer in basic biology labs diagnosed with first virus

2011-01-26
A workhorse of modern biology is sick, and scientists couldn't be happier. Researchers at Washington University School of Medicine in St. Louis, the Jacques Monod Institute in France and Cambridge University have found that the nematode C. elegans, a millimeter-long worm used extensively for decades to study many aspects of biology, can be targeted by naturally occurring viral infections. The discovery means C. elegans is likely to help scientists study the way viruses and their hosts interact. The findings will be published next week in the online, open access journal ...

Shining new light on air pollutants using entangled porous frameworks

2011-01-26
Kyoto, Japan -- Certain types of pollution monitoring may soon become considerably easier. A group of researchers centered at Kyoto University has shown in a recent Nature Communications paper that a newly-formulated entangled framework of porous crystals (porous coordination polymers, or PCPs) can not only capture a variety of common air pollutants, but that the mixtures then glow in specific, easily-detected colors. Lead author for the paper was Dr. Yohei Takashima. Until now, chemical sensors have generally needed to be custom-designed to recognize specific compounds, ...

LAST 30 PRESS RELEASES:

Living in hurricane affected areas could increase mortality of older people by 9% years after disaster

New risk calculator can better predict stroke to direct the best prevention

Social media boosts news diversity amid traditional media decline

HOXB13 in cancer development: molecular mechanisms and clinical implications

Research shows Alaska early quake warning system could provide critical seconds

Researchers discover universal laws of quantum entanglement across all dimensions

Emeishan mantle plume created 400 km gas-rich carbonate belt in Sichuan Basin

On-board camera footage offers bird’s eye glimpse into seabird flights and feeding behaviour

Why birds on the edge stay there: Study sheds light on murmuration mysteries

Fossil-free graphite from biomass for greener process industries

‘Solastalgia’ might help explain effects of climate change on mental health

Childhood verbal abuse shows similar impact to adult mental health as physical abuse

New term for systematic, deliberate attacks on healthcare as acts of war: ‘healthocide’

The Lancet Rheumatology: Course of psychotherapy for low back pain remains effective for at least three years, finds trial

Urbanization linked to a 43 per cent drop in pollinating insects

Media Tip Sheet: Urban ecology at ESA2025

UC Irvine researchers find combination of natural compounds for brain cleaning

Electric double layer structure at nucleation sites revealed, providing fundamental insight into electrochemical cells and batteries

There’s something fishy going on with great white sharks that scientists can’t explain

‘Sweet’ discovery reveals how glucose fuels cancer-fighting immune cells

KBH Energy Center to host symposium

Self assembling monolayer can improve lead-free perovskite solar cells too

Like us, pregnant roaches need more sleep

Unlocking the value of intangible assets abroad requires strong board oversight, new study finds

Internalizing stress may lead to cognitive decline in

'Arctic Monkeys': Early primates survived in cold climates, not tropical forests

How do cells prevent premature protein release? UIC study cracks the case

Study demonstrates excellent potential of earthquake early warning system in Alaska

Wild chimpanzees learn how to communicate from relatives on mom’s side, not dad’s

Kids of obese parents more likely to develop obesity due to inheriting related genes

[Press-News.org] Possible new approach to treating a life-threatening blood disorder