Glucagon-like peptide-1 receptor agonists and risk of neovascular age-related macular degeneration

JAMA Ophthalmology

2025-06-05

(Press-News.org) About The Study: In this cohort study, the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) among patients with diabetes was associated with a 2-fold higher risk of incident neovascular age-related macular degeneration development than among similar patients with diabetes who did not receive a GLP-1 RA. Further research is needed to elucidate the exact pathophysiological mechanisms involved and to understand the trade-offs between the benefits and risks of GLP-1 RAs.

Corresponding Author: To contact the corresponding author, Rajeev H. Muni, MD, MSc, email rajeev.muni@utoronto.ca.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamaophthalmol.2025.1455)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Glucagon-like peptide-1 receptor agonists and risk of neovascular age-related macular degeneration

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