(Press-News.org) Exercise has been recognized as an extremely effective tool to improve human health— it can have a preventative and even therapeutic effect on non-communicable diseases such as diabetes and cardiovascular diseases. By promoting physical activity not only among athletes, but also among the general population, several non-communicable diseases can be prevented, eventually reducing the financial burden upon the healthcare system. However, the exact changes that occur at a molecular level due to different types of exercise have not been explored thoroughly. One reason for this is that, traditionally, collecting molecular information (such as metabolite data) required invasive tissue or muscle biopsies, limiting the scale of studies that could be performed.
Now, in a study published in Volume 11 of the journal Sports Medicine - Open on May 14, 2025, Dr. Kayvan Khoramipour from Miguel de Cervantes European University, along with other coauthors, and Professor Katsuhiko Suzuki from the Faculty of Sport Sciences, Waseda University, Japan, introduce and review literature in two emerging fields that could advance our understanding of exercise physiology in humans. These disciplines use ‘multi-omics’ data, or data from multiple sets of biological molecules (such as proteins, metabolites, or even RNA). Prof. Suzuki and his colleagues have termed these fields as ‘resistomics’ and ‘enduromics.’
The authors explain that ‘enduromics’ and ‘resistomics’ are fields that examine the molecular changes induced by endurance and resistance training, respectively. While endurance training is what we might refer to as aerobic exercise (that increases your breathing and heart rate), resistance training involves improving your muscle strength. To better explain these two terms, Prof. Suzuki further elaborates that, “Enduromics and resistomics examine unique molecular adaptations to endurance and resistance training in a larger population, as opposed to the field of ‘sportomics,’ which focuses on molecular alterations in competitive athletes.”
More specifically, enduromics reveals the biological pathways involved in processes such as lipid metabolism, generation of new mitochondria, and aerobic efficiency, or your body’s ability to effectively use oxygen—all of which adapt and change in response to moderate-to-intense aerobic exercise. On the other hand, resistomics specifically focuses on muscle hypertrophy or muscle growth, synthesis of new proteins, and neuromuscular adaptations in the body. These fields can identify the biomarkers and metabolic fingerprints, aiding in understanding how specific metabolic states differ between individuals. Taken together, both resistomics and enduromics can give us a clear picture of the molecular adaptations that arise in different individuals in response to both resistance and endurance training.
Emphasizing the practical applications of enduromics and resistomics, Prof. Suzuki explains, “By utilizing molecular profiling, these disciplines pave the way for personalized exercise prescriptions, using molecular insights to tailor training to an individual.” He adds that these personalized training plans can enhance fitness and rehabilitation while reducing injury risks for both athletes as well as the general population. The team also believes that by transitioning the focus from athletes to the general population, the collective health of society can be strengthened.
In the long term, Prof. Suzuki and his colleagues would like to discover molecular mechanisms underpinning adaptation to exercise, which could even prove helpful for disease prevention and treatment. We hope that enduromics and resistomics will pave the way for a new approach to exercise and public health!
***
Reference
Authors: Kayvan Khoramipour1, Sergio Maroto-Izquierdo1, Simone Lista1, Alejandro Santos-Lozano1, and Katsuhiko Suzuki2
DOI: 10.1186/s40798-025-00855-4
Affiliations: 1i+HeALTH Strategic Research Group, Department of Health Sciences, Miguel de Cervantes European University (UEMC), Spain
2Faculty of Sport Sciences, Waseda University, Japan
About Waseda University
Located in the heart of Tokyo, Waseda University is a leading private research university that has long been dedicated to academic excellence, innovative research, and civic engagement at both the local and global levels since 1882. The University has produced many changemakers in its history, including eight prime ministers and many leaders in business, science and technology, literature, sports, and film. Waseda has strong collaborations with overseas research institutions and is committed to advancing cutting-edge research and developing leaders who can contribute to the resolution of complex, global social issues. The University has set a target of achieving a zero-carbon campus by 2032, in line with the Sustainable Development Goals (SDGs) adopted by the United Nations in 2015.
To learn more about Waseda University, visit https://www.waseda.jp/top/en
About Professor Katsuhiko Suzuki from Waseda University
Dr. Katsuhiko Suzuki is currently a Professor in the Faculty of Sport Sciences at Waseda University. He completed both his M.D and Ph.D from the Hirosaki University School of Medicine. His research interests include exercise prescription for lifestyle-related diseases and risk assessment of acute and chronic exercise using biochemical and immunological variables. He has published more than 450 papers in the fields of exercise immunology, sports science, muscle damage, exercise biochemistry, and applied physiology, and has accumulated over 20,000 citations for the same, with a high h-index score of 74. He will hold a symposium of the International Society of Exercise Immunology as Chairman in Tokyo in late August 2026. To know more:
https://katsu.suzu.w.waseda.jp/ISEI2026_Tokyo.html
END
No more hunger after cooking? A newly identified network of nerve cells is responsible, a research group at the Max Planck Institute for Metabolism Research has discovered in mice. They discovered a direct connection from the nose to a group of nerve cells in the brain that are activated by the smell of food and, when activated, trigger a feeling of fullness. This was not the case in obese mice. This discovery suggests that treating obesity might require different advice about smelling food before a meal based on a person's weight.
The researchers used brain scans to investigate which regions of the mice's brains respond to ...
Today, 2.2 billion people in the world lack access to safe drinking water. In the United States, more than 46 million people experience water insecurity, living with either no running water or water that is unsafe to drink. The increasing need for drinking water is stretching traditional resources such as rivers, lakes, and reservoirs.
To improve access to safe and affordable drinking water, MIT engineers are tapping into an unconventional source: the air. The Earth’s atmosphere contains millions of billions of gallons of water in the form of vapor. If this vapor can be efficiently captured and condensed, it could supply clean drinking water in ...
CAMBRIDGE, MA -- The human brain is very good at solving complicated problems. One reason for that is that humans can break problems apart into manageable subtasks that are easy to solve one at a time.
This allows us to complete a daily task like going out for coffee by breaking it into steps: getting out of our office building, navigating to the coffee shop, and once there, obtaining the coffee. This strategy helps us to handle obstacles easily. For example, if the elevator is broken, we can revise how we get ...
The forerunners of dinosaurs and crocodiles in the Triassic period were able to migrate across areas of the ancient world deemed completely inhospitable to life, new research suggests.
In a paper published in Nature Ecology and Evolution today (11th June), researchers from the University of Birmingham and University of Bristol have used a new method of geographical analysis to infer how these ancestral reptiles, known as archosauromorphs, dispersed following one of the most impactful climate events the Earth has ever seen, the end-Permian mass extinction.
The first archosauromorphs, some resembling modern reptiles and many ...
Imagine you’re walking to work when the unspeakable occurs: Your favorite coffee shop — where you stop every day — is closed. You groggily navigate to a newly opened coffee shop a couple blocks away, which, you’re pleased to discover, actually makes quite a good morning brew. Soon, you find yourself looking forward to stopping at the new location instead of the old one.
That switch probably alters more than just your morning routine. Each time you visit that new coffee shop, the ...
A team of Korean scientists has developed an innovative green technology that transforms plastic waste into clean hydrogen fuel using only sunlight and water.
Researchers at the Institute for Basic Science (IBS) Center for Nanoparticle Research, led by Professor KIM Dae-Hyeong and Professor HYEON Taeghwan of Seoul National University, announced the successful development of a photocatalytic system that produces hydrogen from PET bottles. The key innovation lies in wrapping the photocatalyst in a hydrogel polymer, which helps it float on water and stay active even under harsh environmental ...
Brain cell discovery may explain excessive hunger
Researchers identify “meal memory” neurons in laboratory rats that could explain why forgetting lunch leads to overeating.
Scientists have discovered a specific group of brain cells that create memories of meals, encoding not just what food was eaten but when it was eaten. The findings, published today in Nature Communications, could explain why people with memory problems often overeat and why forgetting about a recent meal can trigger excessive hunger and lead to disordered eating.
During eating, neurons in the ventral hippocampus region of the brain become active and form what the team of researchers call ...
A new study from Karolinska Institutet involving over a million women links difficult childhood experiences to the risk of being diagnosed with endometriosis later in life. The study shows a link between childhood exposure to violence and a twofold increase in the risk of developing this gynaecological disease.
Endometriosis is a condition in which tissue similar to the lining of the uterus grows outside the uterus. These cells attach to the abdominal lining, uterus, ovaries or other organs and form endometriosis lesions. The lesions react to ...
About The Study: Augmenting enteral protein during critical illness did not improve number of days free of the index hospital and alive at day 90.
Corresponding Author: To contact the corresponding author, Adam M. Deane, PhD, email Adam.deane@mh.org.au.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jama.2025.9110)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding ...
CLEVELAND—Pancreatic cancer has a five-year survival rate of just 13%, making it the deadliest cancer, according to the American Cancer Society. It typically causes no symptoms until it has already metastasized. Surgery, radiation and chemotherapy can extend survival, but rarely provide a cure.
Now, researchers at Case Western Reserve University and Cleveland Clinic are developing vaccines targeting pancreatic cancer that could eliminate the disease, leaving a patient cancer-free. So far, the vaccines have achieved dramatic results ...
