PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Effect of respiratory phase on three-dimensional quantitative parameters of pulmonary subsolid nodules in low-dose computed tomography screening for lung cancer

2025-06-16
(Press-News.org) Background: In the screening of pulmonary subsolid nodules (SSNs), it is crucial to compare the quantitative parameters under consistent computed tomography (CT) acquisition conditions, including the same degree of lung inflation. When non-end-inspiratory chest CT scan is performed due to poor breath holding, there is a risk of inaccurate measurement of quantitative parameters and erroneous assessment of pulmonary nodule growth. This study aims to investigate the effect of respiratory phase on three-dimensional (3D) quantitative parameters of SSNs, and to further explore the impact of respiratory phase change on the judgment of SSNs growth during the follow-up of low-dose CT (LDCT) screening.

Methods: There were 255 pulmonary SSNs retrospectively found in 230 subjects who received low-dose paired inspiratory and expiratory chest CT screening. Quantitative parameters of lung and SSNs on paired inspiratory and expiratory CT were obtained. The change ratio of expiratory to inspiratory parameters was calculated and labeled as parameter(E-I)/I. Quantitative parameters were compared between inspiratory and expiratory CT. The difference of the change ratio of different quantitative parameters was also compared. The change ratio of quantitative parameters of SSNs was compared between different density types, sizes and locations. The 255 nodules were divided into two groups (the changed and unchanged group) according to the growth criteria. The quantitative parameters and the change ratio of quantitative parameters were compared between the two groups. The significant factors were included in the multivariate logistic regression analysis.

Results: There were statistical differences in all quantitative parameters of lung nodules between the inspiratory CT and the expiratory CT (all P<0.05). The change ratio of long axis diameter of nodules (7.14%) was the smallest, and the change ratio of volume of nodules (20.21%) was the largest. Significant differences were found in the change ratio of most quantitative parameters between part-solid nodules (PSNs) and pure ground-glass nodules (pGGNs). There was no statistical difference in the change ratio of all nodules’ parameters between the ≤10 mm group and the >10 mm group (all P>0.05). Nodule density(E-I)/I in lower lobes was greater than that in upper lobes (P<0.001). Significant differences were found in the change ratio of lung volume, the change ratio of long axis diameter and density of nodules, and all quantitative parameters of nodules on inspiratory CT between the changed group and the unchanged group (all P<0.05). Multivariate logistic regression analysis showed that the lung density, long axis diameter, short axis diameter, surface area and density of nodules on inspiratory CT were independent indicators for predicting whether SSNs change with respiratory phase.

Conclusions: Respiratory phase had the greatest effect on the volume of pulmonary SSNs and the least effect on the long axis diameter. During follow-up, LDCT scan in different respiratory phases may interfere with the judgment of the growth of pulmonary SSNs.

END


ELSE PRESS RELEASES FROM THIS DATE:

USC-led team sheds light on dark matter by simulating twins of our Milky Way galaxy

2025-06-16
A USC-led research team has created a series of supercomputer-simulated twins of our Milky Way galaxy—which could help scientists unlock new answers about one of the biggest mysteries in the universe: dark matter, the invisible substance that makes up about 85% of all matter in existence. The research was led by cosmologist Vera Gluscevic, who is an associate professor at the USC Dornsife College of Letters, Arts, and Sciences; as well as Ethan Nadler, formerly a postdoc at USC and Carnegie Observatories who is now an assistant professor at University of California, San Diego; and Andrew Benson, a staff scientist at Carnegie Observatories. They called ...

Researchers identify previously uncharacterized gene necessary for DNA repair

2025-06-16
EMBARGOED by Nature Cell Biology until 5 p.m. ET, June 16, 2025 Contacts: BU: Gina DiGravio, 617-358-7838, ginad@bu.edu MGH/Harvard: Marcela Quintanilla Dieck, 617-480-6501, MQuintanillaDieck@MGH.HARVARD.EDU Researchers Identify Previously Uncharacterized Gene Necessary for DNA Repair Study establishes for the first time that defective DNA repair may be the major driver of several clinical features associated with a subset of patients with 22q11.2 distal deletion syndrome (Boston)—Cells are constantly subjected to ...

Clearing out the clutter: how people retain important information from memories

2025-06-16
Removing information from memories may help people retain what they want to remember. Studies focus on how the brain removes information by subconsciously not paying attention to these details, but sometimes there is a need to consciously remove unneeded details from memories. This is especially true when details in a memory are perceptibly harmful and lead to, for example, people combating rumination, intrusive negative thoughts, or hallucinations. In a new JNeurosci paper, Jiangang Shan and Bradley Postle, from the University of Wisconsin-Madison, explored how the brain actively removes unneeded memory content.  The researchers recorded the brain activity of nearly 30 ...

High blood pressure in pregnancy linked to increased risk of seizure in children

2025-06-16
A new study led by researchers at University of Iowa Health Care has revealed a significant association between high blood pressure during pregnancy (gestational hypertension) and an increased risk of seizures in children.  The study, published June 16 in the Journal of Clinical Investigation, used extensive clinical databases and innovative animal models to uncover this critical link. The findings also suggest that inflammation in the brain may play a role in connecting gestational hypertension to seizure risk and could potentially be targeted to prevent seizures in children exposed to hypertension in the womb.   Clinical data links seizure risk in children ...

SwRI’s Angel Wileman named one of Women in Hydrogen 50 for 2025

2025-06-16
SAN ANTONIO — June 16, 2025 — The Women’s Global Leadership Conference (WGLC) in Energy has selected Southwest Research Institute’s Angel Wileman for 2025’s Women in Hydrogen 50. This list recognizes 50 women, nominated by their colleagues and peers, as the current and future leaders of the hydrogen economy. This distinction honors Wileman as one of the most accomplished figures in her industry, with the potential to affect real change. “I am deeply honored to be recognized as a leader in the hydrogen community. Society has the ...

XXIX Brazilian Congress of Nutrology

2025-06-16
The XXIX Brazilian Congress of Nutrology – CBN 2025 (link: https://abran.org.br/cbn2025/) promises to be a milestone in the health sector, being the main event dedicated to Nutrology in all of Latin America. This exceptional meeting will bring together renowned national and international experts, providing an environment conducive to the exchange of cutting-edge knowledge, the promotion of scientific innovation and the stimulation of integration among nutrology professionals. Scheduled for September 25, 26 and 27, CBN 2025 will take ...

Life expectancy of American Indian and Alaska Native persons and underreporting of mortality in vital statistics

2025-06-16
About The Study: This longitudinal cohort study found that large life expectancy differences between American Indian and Alaska Native individuals and other U.S. residents have been underestimated due to racial misclassification on death certificates, resulting in the statistical erasure of Indigenous people in routine vital statistics.  Corresponding Author: To contact the corresponding author, Jacob Bor, SD, email jbor@bu.edu. To access the embargoed study: Visit our For The Media website ...

Official US records underestimate Native Americans deaths and life expectancy

2025-06-16
A new study in JAMA reveals the “statistical erasure” of Indigenous Americans, finding that the gap between AI/AN life expectancy and the national average was 2.9 times greater than official vital statistics indicate. Death rates for American Indians’ and Alaska Natives (AI/AN) are far higher than reported in official vital statistics, according to a new study led by a Boston University School of Public Health (BUSPH) researcher.  Published in JAMA, the nationally representative study found that death certificates for at least 41 percent of AI/AN decedents failed to identify them as AI/AN, in most cases misreporting ...

Father’s mental health plays key role in child development, research shows

2025-06-16
Experts from Ann & Robert H. Lurie Children’s Hospital of Chicago affirm the need to screen new fathers for mental distress, recognizing the mounting research that underscores the importance of fathers in child development. Their invited commentary, published in JAMA Pediatrics, accompanies a systematic review, which found that paternal depression, anxiety and stress in the perinatal period are associated with poorer child development in social, emotional, cognitive and language domains. “Birth of a child can be highly stressful for both parents,” said lead author Craig Garfield, MD, MAPP, pediatrician and founder of the Family & Child Health Innovations ...

Public water arsenic and birth outcomes in the Environmental Influences on Child Health Outcomes Cohort

2025-06-16
About The Study: In this cohort study of birthing parent–infant dyads across the U.S., arsenic measured in public water systems was associated with birth outcomes at levels below the current U.S. Environmental Protection Agency’s maximum contaminant level. The findings suggest that further reducing the maximum contaminant level for arsenic may decrease the number of infants with low birth weight in the U.S.  Corresponding Author: To contact the corresponding author, Anne E. Nigra, ScM, PhD, email aen2136@cumc.columbia.edu. To access the embargoed study: Visit our For The Media website at ...

LAST 30 PRESS RELEASES:

Japan’s first nationwide survey highlights gaps in patient engagement for allergy research

World’s first pig-to-human liver xenotransplant in a living recipient reported in the Journal of Hepatology

The Lancet: Tens of thousands of children aged under five suffering acute malnutrition in Gaza, recent estimates suggest

Prostate testing may not target those most likely to benefit, warn experts

Global analysis shows hidden damage from men’s alcohol use

DRI recognizes Ashley Cornish as the 2025 Peter B. Wagner Memorial Award Winner for Women in Atmospheric Sciences

Unlocking the blueprint for a powerful plant-based drug

Bringing modern science to vitamin biology: Isha Jain wins NIH Transformative Research Award

University of Houston scientists learn that rare bacterium ‘plays dead’ to survive

Introduced animals change how island plants spread, new global study finds

Mayo Clinic researchers discover ‘traffic controller’ protein that protects DNA, and may help kill cancer cells

Protein sidekick exhibits dual roles in stress granule assembly and disassembly

New hope for MS

Kennesaw State professor receives grant to study cancer origins

Pain and antidepressant drug combo linked to increased seizure risk in older adults

Cancer researchers shape new strategies for immunotherapy

Physical exercise can ‘train’ the immune system

Calm red brocket deer can learn to "Come" and other commands - but the flightiest, most restless individuals struggle

China, the world's largest tea producer, is predicted to experience increases in land suitable for tea-growing under climate change, with the overall range shifting northwards, per AI modeling study

Composing crews for Mars missions

Early humans butchered elephants using small tools and made big tools from their bones

1,000-year-old gut microbiome revealed for young man who lived in pre-Hispanic Mexico

Bears and pandas in captivity develop significantly different gut microbiomes compared to their wild counterparts, and giant pandas in particular have less diverse microbiomes than their wild counterp

Prenatal and postnatal support apps might not work

Dancing dust devils trace raging winds on Mars

Raging winds on Mars

Real-time biopsies uncover hidden response to glioblastoma therapy

Repeated brain tumor sampling uncovers treatment response in patients with glioblastoma

Novel immunotherapy combination destroys colorectal liver metastases

Farmed totoaba could curb poaching

[Press-News.org] Effect of respiratory phase on three-dimensional quantitative parameters of pulmonary subsolid nodules in low-dose computed tomography screening for lung cancer