Illuminated changes: Enhancing D-lactic acid output with UV irradiation

Improved production of compounds from methanol and Komagataella phaffii yeast achieved through DNA alteration

2025-06-17

(Press-News.org) Amid concerns over rising petroleum prices and resource depletion, organic compounds such as methanol are attracting attention as potential replacements. Though this bodes well in theory, the production of raw materials from methanol relies on costly chemical processes. An energy-saving, bio-based process is necessary for fully tapping into this resource.

To make this a reality, Associate Professor Ryosuke Yamada’s team at Osaka Metropolitan University’s Graduate School of Engineering has developed a Komagataella phaffii (K. phaffii) yeast strain that can efficiently produce D-lactic acid, a raw material for pharmaceuticals and bioplastics, from methanol.

In their research, the team used ultraviolet irradiation to damage K. phaffii cell DNA and induce gene mutations to improve D-lactic acid output. The exposure to ultraviolet rays successfully created a new strain, DLac_Mut2_221, that produces approximately 1.5 times more D-lactic acid.

“Further, we performed genetic analyses using next-generation sequencers and identified the genes involved in improving D-lactic acid productivity,” stated Professor Yamada. “Going forward, we plan to further improve the efficiency of D-lactic acid production from K. phaffii and develop technologies for producing other useful compounds from methanol.”

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About OMU

Established in Osaka as one of the largest public universities in Japan, Osaka Metropolitan University is committed to shaping the future of society through “Convergence of Knowledge” and the promotion of world-class research. For more research news, visit https://www.omu.ac.jp/en/ and follow us on social media: X, Facebook, Instagram, LinkedIn.

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