Weekly semaglutide improves blood sugar and weight in adults with Type 1 diabetes

A double-blind clinical trial shows promising results

2025-06-23

(Press-News.org) A new clinical trial found that taking a popular diabetes and weight-loss drug once weekly significantly improves blood sugar and leads to substantial weight loss in adults with Type 1 diabetes who use automated insulin delivery systems.

The results were published today in the journal NEJM Evidence.

Semaglutide is a medication that belongs to a class of drugs known as glucagon-like peptide-1, or GLP-1, receptor agonists. Sold under the trade names such as Ozempic, Wegovy and Rybelsus, the drug was initially developed for the treatment of Type 2 diabetes, helping to manage blood sugar levels.

The 26-week, double-blind study involved 72 participants across four medical centers, including Oregon Health & Science University. Researchers found that 36% of patients taking semaglutide met all three key health goals — improved blood glucose levels, reduced time spent in low blood sugar and at least 5% weight loss — compared to none in the placebo group.

“Semaglutide helped more people reach their blood sugar and weight goals without decreasing blood sugar,” said Andrew Ahmann, M.D., emeritus professor of medicine at Oregon Health & Science University’s School of Medicine, and a co-author on the study.

Those on semaglutide lost an average of about 18.5 pounds over six months in the study and saw modest improvements in average blood sugar levels (A1C) and the amount of time blood sugar stays in a healthy range, without a higher risk of dangerous low blood sugar or serious complications like diabetic ketoacidosis.

While semaglutide is already approved for Type 2 diabetes and obesity, its use in Type 1 diabetes remains investigational. This is the first randomized clinical trial to show that the medication may also be effective in Type 1 diabetes in patients already using automated insulin delivery.

Viral Shah, M.D., of the Indiana University School of Medicine, is senior author on the study. In addition to Shah and Ahmann, other co-authors include Halis Akturk, M.D. and Janet Snell-Bergeon, Ph.D., of University of Colorado Anschutz Medical Campus, Davida Kruger, D.N.P., M.D., of Henry Ford Health, Anuj Bhargava, M.D., of Iowa Diabetes Research, Giorgos Bakoyannis, Ph.D., of Indiana University School of Medicine, and Laura Pyle, Ph.D., of the University of Washington.

The research reported in this publication was supported by Breakthrough T1D, Clinicaltrials.gov number NCT05537233.

END

ELSE PRESS RELEASES FROM THIS DATE:

Concerned father, statistician develops software to improve skills therapy

2025-06-23

UNIVERSITY PARK, Pa. — Mabel Ramos’s favorite song is “Ghostbusters” by Ray Parker Junior. From morning until night, if Mabel is awake, she is listening and dancing to — or asking to listen to — the number one Billboard hit from 1984. Though some parents might be annoyed by listening to a single song repeatedly, her father, Mark Ramos, said he is delighted by his daughter’s ability to dance, communicate and express her enthusiasm. Mabel, who is five years old, has autism spectrum disorder. Mark, assistant research professor of health policy and administration at ...

Your smartwatch might know you’re sick before you do — and it might help stop pandemics

2025-06-23

Smartwatch features that measure heart rates, oxygen levels, fitness levels and sleep quality have been marketed as valuable tools for people who are eager to monitor their health. But what if these features could do more than detect potential health issues — what if they could prevent potential health disasters such as pandemics? Recent studies have demonstrated that smartwatches’ health apps and sensors provide enough information to accurately predict when a person has become infected with a disease like COVID-19 or the flu, even within as few as 12 hours after infection. In a study published this March in PNAS Nexus, researchers ...

ImmunoPET tracer enhances early detection of liver cancer

2025-06-23

NEW ORLEANS—A novel molecular imaging agent targeting glypican-3 (GPC3) has demonstrated high sensitivity and specificity in detecting hepatocellular carcinoma (HCC), including tumors smaller than one centimeter, according to results from a pilot clinical study. The agent, 68Ga-aGPC3-scFv, coded as XH06, was shown to be safe, well-tolerated, and effective at providing high-contrast images of GPC3-positive liver tumors, offering a promising new tool for early diagnosis and staging of HCC—one of the most lethal forms of liver cancer. ...

AI-based brain-mapping software receives FDA market authorization

2025-06-23

A new AI-based technology that rapidly maps the brain to locate sensitive areas that control speech, vision, movement and other critical functions has received authorization from the Food and Drug Administration (FDA), enabling it to be marketed to hospitals with the aim of enhancing the precision of neurosurgeries. The technology was developed by researchers and clinicians at Washington University School of Medicine in St. Louis to more precisely guide neurosurgeons in performing delicate brain surgeries to remove tumors or treat epilepsy, for example. The Cirrus Resting ...

New PET tracer identifies diverse invasive mold infections behind life-threatening illnesses in cancer and transplant patients

2025-06-23

NEW ORLEANS (June 23, 2025)—A novel PET radiotracer can accurately detect a wide range of mold species that are linked to dangerous infections, according to new research presented at the Society of Nuclear Medicine and Molecular Imaging 2025 Annual Meeting. The imaging agent has the potential to dramatically enhance the diagnosis and monitoring of invasive mold infections in patients. Advances in cancer and immunosuppressive treatments have helped many patients live longer, but they also leave more people with weakened immune systems, making invasive mold ...

Current Pharmaceutical Analysis (CPA) achieves notable impact factor growth in latest journal citation reports

2025-06-23

In 2025-06-18, the highly anticipated 2024 Journal Citation Reports (JCR) were released, revealing significant progress for the journal Current Pharmaceutical Analysis (CPA). The journal has achieved an impact factor of 1.5, marking a remarkable doubling from the previous year. This accomplishment underscores CPA's growing academic influence and recognition within the field of pharmacology and pharmacy. The impact factor, a core metric for evaluating a journal's academic impact, reflects the average ...

AI chatbot safeguards fail to prevent spread of health disinformation

2025-06-23

Embargoed for release until 5:00 p.m. ET on Monday 23 June 2025 Follow @Annalsofim on X, Facebook, Instagram, threads, and Linkedin Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent. ---------------------------- 1. ...

UTIA researcher to receive award from the Soil and Water Conservation Society

2025-06-23

Sindhu Jagadamma, associate professor of soil science at the University of Tennessee Institute of Agriculture, will receive the Soil and Water Conservation Society’s 2025 Conservation Research Award at the society’s annual conference in August. Soil health is critical for sustainable food production, and Jagadamma’s research in her Sustainable Soil Management Lab are developing ways to mitigate soil and environmental problems associated with conventional farm management practices. Her team studies how to maintain soil health through the implementation of conservation management, ...

HSE linguists study how bilinguals use phrases with numerals in Russian

2025-06-23

Researchers at HSE University analysed over 4,000 examples of Russian spoken by bilinguals for whom Russian is a second language, collected from seven regions of Russia. They found that most non-standard numeral constructions are influenced not only by the speakers’ native languages but also by how frequently these expressions occur in everyday speech. For example, common phrases like 'two hours' or 'five kilometres’ almost always match the standard literary form, while less familiar expressions—especially ...

Cold winters halt the northward spread of species in a warming climate

2025-06-23

As the climate warms, many species are shifting northward into areas that were previously too cold for them. A new study on the wall brown butterfly, published in the scientific journal PNAS, shows that rapid evolution can aid this process – but only up to a point. Cold winters stop further expansion beyond certain climatic limits. “Our results show that even though the butterflies adapt their life cycle as they move northwards, there are limits that evolution cannot easily overcome,” says Mats Ittonen, one of the lead authors of the study done by researchers at the Department of Zoology, Stockholm University. The wall brown (Lasiommata ...

LAST 30 PRESS RELEASES:

Can medical AI lie? Large study maps how LLMs handle health misinformation

The Lancet: People with obesity at 70% higher risk of serious infection with one in ten infectious disease deaths globally potentially linked to obesity, study suggests