(Press-News.org) A new study by investigators from Mass General Brigham adds evidence that the most effective way to prevent preterm birth among patients with a history of cervical insufficiency is to place a cervical stitch higher in the abdomen rather than vaginally. This difference in surgical technique was associated with a 70% reduction in risk of preterm birth (birth before 34 weeks) among patients at Brigham and Women’s Hospital (BWH), a founding member of the Mass General Brigham healthcare system, where approximately 6,200 babies are born every year. Results are published in The American Journal of Obstetrics and Gynecology (AJOG).
“Our goal is to ensure a healthy pregnancy and safe delivery for every patient who comes to the hospital. We have data from a previous clinical trial that shows it’s important to choose the right surgical technique to help patients who are at very high risk for recurrent preterm birth. Our study suggests that finding translates to a population of slightly lower-risk women, who are sometimes offered these interventions,” said lead author Chelsea J. Messinger, MD, PhD, of the Department of Anesthesiology at Mass General Brigham.
The study examined an obstetric population at BWH with lower average risk for recurrent early preterm birth than that of an earlier clinical trial, The Multicentre Abdominal vs. Vaginal Randomised Intervention of Cerclage (MAVRIC). Both MAVRIC and the new study compared two surgical methods to prevent preterm births in patients with a history of cervical insufficiency. Cervical insufficiency is a condition in which the cervix opens too early during pregnancy, increasing the risk of a miscarriage or early delivery, and can be treated with a surgical technique in which a stitch is placed to support the cervix.
For the new study, researchers identified two cohorts of singleton pregnancies at BWH between Jan. 1, 2001 and Feb. 28, 2021. The study included 188 patients, of whom 87 received a transabdominal cerclage (TAC), in which a stitch is placed higher in the abdomen, and 101 received a transvaginal cerclage (TVC), in which the stitch is placed vaginally. Eighty-six of the 87 TACs were placed via a minimally invasive approach. After adjusting for sources of bias, researchers found that 5.5% of TAC patients delivered before 34 weeks, compared to 18.7% of TVC patients. Complications from surgery were rare but included uterine perforation and rupture in the TAC group. In the study of BWH patients, Messinger and colleagues found that TAC was associated with a 70% reduced risk of preterm birth compared to TVC. MAVRIC had a similar finding, reporting a 77% reduction in risk.
While the research offers promising information for women with history of cervical insufficiency, researchers emphasize the importance of shared decision-making between patients and their healthcare providers regarding which procedure, if any, may be optimal for individual patients. This includes careful consideration of whether the potential benefits of TAC outweigh the risks of abdominal surgery and Cesarean delivery among patients with fewer risk factors for recurrent preterm birth or miscarriage compared to patients in MAVRIC.
Authorship: In addition to Messinger, Mass General Brigham authors include Sonia Hernández-Diaz, Albert Hofman, Natalie Sadlak, Jon Einarsson, Thomas McElrath.
Disclosures: None.
Mirvie Inc (scientific advisory board, equity payment); Hoffman – LaRoache (scientific advisory board); Comanche Biopharma, Inc. (scientific advisory board payment). Hernández-Diaz has consulted for Roche and Moderna, and received grants from Takeda and UCB, for unrelated work. Einarsson is a consultant for Arthrex. The remaining authors report no conflict of interest.
Funding: Funding provided by National Institute of General Medical Sciences (T32GM144273 and T32GM007753) and the National Institute on Aging (T32AG051108)
Paper cited: Messinger, C. et al. “ Effect of transabdominal versus transvaginal cerclage on preterm birth and neonatal outcomes among patients with history of cervical insufficiency” AJOG DOI: 10.1016/j.ajog.2025.06.049
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About Mass General Brigham
Mass General Brigham is an integrated academic health care system, uniting great minds to solve the hardest problems in medicine for our communities and the world. Mass General Brigham connects a full continuum of care across a system of academic medical centers, community and specialty hospitals, a health insurance plan, physician networks, community health centers, home care, and long-term care services. Mass General Brigham is a nonprofit organization committed to patient care, research, teaching, and service to the community. In addition, Mass General Brigham is one of the nation’s leading biomedical research organizations with several Harvard Medical School teaching hospitals. For more information, please visit massgeneralbrigham.org.
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