(Press-News.org) About The Study: In this randomized clinical trial of antihypertensive chronotherapy, bedtime dosing provided better control of nocturnal blood pressure and improved the circadian rhythm, without reducing the efficacy on mean daytime or 24-hour blood pressure, or increasing the risk of nocturnal hypotension. These findings support the potential advantages of bedtime administration and offer new evidence to guide future research on antihypertensive chronotherapy.
Corresponding Author: To contact the corresponding author, Xiaoping Chen, MD, email xiaopingchen15@126.com.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2025.19354)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.19354?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=070925
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
END
Morning vs bedtime dosing and nocturnal blood pressure reduction in patients with hypertension
JAMA Network Open
2025-07-09
ELSE PRESS RELEASES FROM THIS DATE:
BMI in children before, during, and after the COVID-19 pandemic
2025-07-09
About The Study: This cross-sectional study including 426,000 children in Denmark found that body mass index (BMI) outcomes of COVID-19 pandemic–related control policies and restrictions were not exclusively observed among children with obesity, which suggests that pandemic-related mitigation policies targeting children and adolescents in all BMI categories are warranted. The findings of this study highlight differences among children of varying ages and BMI classes.
Corresponding Author: To contact ...
Branching out: Tomato genes point to new medicines
2025-07-09
Picture juicy red tomatoes on the vine. What do you see? Some tomato varieties have straight vines. Others are branched. The question is why. New research from Cold Spring Harbor Laboratory (CSHL) provides the strongest evidence to date that the answer lies in what are called cryptic mutations. The findings have implications for agriculture and medicine, as they could help scientists fine-tune plant breeding techniques and clinical therapeutics.
Cryptic mutations are differences in DNA that don’t affect physical traits unless certain other genetic changes occur at the same time. CSHL Professor & HHMI Investigator Zachary Lippman has ...
Charité study analyzes 400 million years of enzyme evolution
2025-07-09
Enzymes catalyze chemical reactions in organisms - without which life would not be possible. Leveraging AlphaFold2 artificial intelligence, researchers at Charité – Universitätsmedizin Berlin have now succeeded in analyzing the laws of their evolution on a large scale. In the journal Nature*, they describe the parts of enzymes that change comparatively quickly and the parts that remain practically unchanged over time. These findings are relevant to the development of new antibiotics, for example.
Enzymes resemble ...
Large-scale DNA study maps 37,000 years of disease history
2025-07-09
A research team led by Eske Willerslev, professor at the University of Copenhagen and the University of Cambridge, has recovered ancient DNA from 214 known human pathogens in prehistoric humans from Eurasia.
The study shows, among other things, that the earliest known evidence of zoonotic diseases – illnesses transmitted from animals to humans, like COVID in recent times – dates back to around 6,500 years ago, with such diseases becoming more widespread approximately 5,000 years ago. It is ...
Results from largest review of its kind on antidepressant withdrawal symptoms
2025-07-09
The largest review of ‘gold standard’ antidepressant withdrawal studies to date has identified the type and incidence of symptoms experienced by people discontinuing antidepressants, finding most people do not experience severe withdrawal.
In a systematic review and meta-analysis of previous randomised controlled trials relating to antidepressant withdrawal, a team of researchers led by Imperial College London and King’s College London concluded that, while participants who stopped antidepressants did experience an average of one more symptom than those who continued or were taking ...
Twist to the M-ax(is): New twist platform opens path to quantum simulation of more exotic states of matter
2025-07-09
Twisted materials—known as moiré structures—have revolutionized modern physics, emerging as today's "alchemy" by creating entirely new phases of matter through simple geometric manipulation. The term "moiré" may sound familiar—it describes the strange rippling patterns you sometimes see when photographing striped shirts or screens; in physics, the same underlying principle applies at the atomic scale. Imagine taking two atomically thin sheets of either the same or different materials, stacking them up together, and rotating one layer slightly relative ...
Chang'e-6 samples unlock secrets of the Moon’s farside
2025-07-09
The Moon's near and far sides exhibit striking asymmetry—from topography and crustal thickness to volcanic activity—yet the origins of these differences long puzzled scientists. China's Chang'e-6 mission, launched on May 3, 2024, changed this by returning 1,935.3 grams of material from the lunar farside's South Pole–Aitken Basin (SPA), the Moon's largest, deepest, and oldest known impact structure, measuring 2,500 kilometers in diameter. The samples arrived on Earth on June 25, 2024.
Previous studies indicated that the SPA was formed by a colossal impact approximately 4.25 billion years ago, releasing energy greater than that of a trillion ...
Teaching lasers to self-correct in high-precision patterned laser micro-grooving
2025-07-09
In International Journal of Extreme Manufacturing, a new laser machining method that dynamically adapts its beam shape is proposed to fabricate microgrooves with complex, highly precise cross-sections—some with a root mean square error decreased to less than 0.5 μm when processing microgrooves with a width of 10 μm.
The technique, developed by researchers at the Southern University of Science and Technology (SUSTech) in Shenzhen, China, could advance the production of microfluidic devices, sensors, and heat dissipation systems by allowing for rapid and scalable manufacturing of custom microstructures.
Laser micromachining has long been constrained by the fundamental ...
EGFR-targeted therapy resistance in breast and head & neck cancers
2025-07-09
“By synthesizing current insights on both RTK and non-RTK mediated resistance against anti-EGFR therapies, this review aims to guide future research and improve therapeutic strategies for these cancers.”
BUFFALO, NY – July 9, 2025 – A new review was published in Volume 16 of Oncotarget on June 25, 2025, titled “Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms.”
Researchers from the University of Cincinnati and Cincinnati ...
JMIR Medical Informatics invites submissions on ambient AI scribes and AI-driven documentation technologies
2025-07-09
(Toronto, July 9, 2025) JMIR Publications invites submissions to a new theme issue titled “Ambient AI Scribes and AI-Driven Documentation Technologies” in its open access journal JMIR Medical Informatics. The premier, peer-reviewed journal is indexed in MEDLINE, PubMed, PubMed Central, DOAJ, Scopus, and the Science Citation Index Expanded (SCIE).
Recent developments in generative artificial intelligence (AI) offer a promising pathway for reducing long-standing administrative burdens for physicians and clinicians. Specifically, there is a rapidly evolving field of ambient AI ...
LAST 30 PRESS RELEASES:
Paleontologist Stephen Chester and colleagues reveal new clues about early primate evolution
UF research finds a gentler way to treat aggressive gum disease
Strong alcohol policy could reduce cancer in Canada
Air pollution from wildfires linked to higher rate of stroke
Tiny flows, big insights: microfluidics system boosts super-resolution microscopy
Pennington Biomedical researcher publishes editorial in leading American Heart Association journal
New tool reveals the secrets of HIV-infected cells
HMH scientists calculate breathing-brain wave rhythms in deepest sleep
Electron microscopy shows ‘mouse bite’ defects in semiconductors
Ochsner Children's CEO joins Make-A-Wish Board
Research spotlight: Exploring the neural basis of visual imagination
Wildlife imaging shows that AI models aren’t as smart as we think
Prolonged drought linked to instability in key nitrogen-cycling microbes in Connecticut salt marsh
Self-cleaning fuel cells? Researchers reveal steam-powered fix for ‘sulfur poisoning’
Bacteria found in mouth and gut may help protect against severe peanut allergic reactions
Ultra-processed foods in preschool years associated with behavioural difficulties in childhood
A fanged frog long thought to be one species is revealing itself to be several
Weill Cornell Medicine selected for Prostate Cancer Foundation Challenge Award
Largest high-precision 3D facial database built in China, enabling more lifelike digital humans
SwRI upgrades facilities to expand subsurface safety valve testing to new application
Iron deficiency blocks the growth of young pancreatic cells
Selective forest thinning in the eastern Cascades supports both snowpack and wildfire resilience
A sea of light: HETDEX astronomers reveal hidden structures in the young universe
Some young gamers may be at higher risk of mental health problems, but family and school support can help
Reduce rust by dumping your wok twice, and other kitchen tips
High-fat diet accelerates breast cancer tumor growth and invasion
Leveraging AI models, neuroscientists parse canary songs to better understand human speech
Ultraprocessed food consumption and behavioral outcomes in Canadian children
The ISSCR honors Dr. Kyle M. Loh with the 2026 Early Career Impact Award for Transformative Advances in Stem Cell Biology
The ISSCR honors Alexander Meissner with the 2026 ISSCR Momentum Award for exceptional work in developmental and stem cell epigenetics
[Press-News.org] Morning vs bedtime dosing and nocturnal blood pressure reduction in patients with hypertensionJAMA Network Open