(Press-News.org) https://doi.org/10.1016/j.apsb.2025.04.017
This new article publication from Acta Pharmaceutica Sinica B, discusses how SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts.
Idiopathic pulmonary fibrosis (IPF), a chronic interstitial lung disease, is characterized by aberrant wound healing, excessive scarring and the formation of myofibroblastic foci. Although the role of alternative splicing (AS) in the pathogenesis of organ fibrosis has garnered increasing attention, its specific contribution to pulmonary fibrosis remains incompletely understood.
In this study, an up-regulation of serine/arginine-rich splicing factor 7 (SRSF7) was identified in lung fibroblasts derived from IPF patients and a bleomycin (BLM)-induced mouse model, and further characterized its functional role in both human fetal lung fibroblasts and mice.
It was demonstrated that enhanced expression of Srsf7 in mice spontaneously induced alveolar collagen accumulation. Mechanistically, alternative splicing events were investigated and revealed that SRSF7 modulates the alternative splicing of pyruvate kinase (PKM), leading to metabolic dysregulation and fibroblast activation.
In vivo studies showed that fibroblast-specific knockout of Srsf7 in conditional knockout mice conferred resistance to bleomycin-induced pulmonary fibrosis. Importantly, through drug screening, lomitapide was identified as a novel modulator of SRSF7, which effectively mitigated experimental pulmonary fibrosis.
Collectively, these findings elucidate a molecular pathway by which SRSF7 drives fibroblast metabolic dysregulation and propose a potential therapeutic strategy for pulmonary fibrosis.
Keywords: IPF, Alternative splicing, Splicing factor, SRSF7, PKM, Fibroblasts, Metabolism, Drug screening
Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S2211383525002746-ga1_lrg.jpg
SRSF7 regulates the alternative splicing of PKM, leading to dysregulation of glycolysis and activation of fibroblasts. This study highlights targeting the SRSF7–PKM axis as a promising therapeutic strategy for IPF.
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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
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CiteScore: 24.3
Impact Factor: 14.6 (Top 6 journal in the category of Pharmacology and pharmacy)
JIF without self-citation: 13.8
ISSN 2211-3835
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Tongzhu Jin, Huiying Gao, Yuquan Wang, Zhiwei Ning, Danyang Bing, Yan Wang, Yi Chen, Xiaomu Tian, Qiudi Liu, Zhihui Niu, Jiayu Guo, Jian Sun, Ruoxuan Yang, Qianqian Wang, Shifen Li, Tianyu Li, Yuhong Zhou, Wenxin He, Yanjie Lu, Yunyan Gu, Haihai Liang, SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts, Acta Pharmaceutica Sinica B, Volume 15, Issue 6, 2025, Pages 3041-3058, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2025.04.017
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https://doi.org/10.1016/j.apsb.2025.04.001
This new article publication from Acta Pharmaceutica Sinica B, discusses how a psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis.
Ovarian tumor (OT) is the most lethal form of gynecologic malignancy, with minimal improvements in patient outcomes over the past several decades. Metastasis is the leading cause of ovarian cancer-related deaths, yet the underlying mechanisms remain poorly understood.
Psychological stress is known to activate ...
https://doi.org/10.1016/j.apsb.2025.04.008
This new article publication from Acta Pharmaceutica Sinica B, discusses how an anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut–lung axis and NLRP3 inflammasome activation.
The coinfection of respiratory viruses and bacteria is a major cause of morbidity and mortality worldwide, despite the development of vaccines and powerful antibiotics. As a macromolecule that is difficult to absorb in the gastrointestinal tract, a homogeneous polysaccharide from Houttuynia cordata (HCPM) has been reported ...
https://doi.org/10.1016/j.apsb.2025.04.018
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Chemotherapy is currently the mainstay of systemic management for triple-negative breast cancer (TNBC), but chemoresistance significantly impacts patient outcomes.
This research indicates that Doxorubicin (Dox)-resistant TNBC cells exhibit increased glycolysis and ATP generation compared to their parental cells, with this metabolic shift contributing to chemoresistance. It was discovered ...
https://doi.org/10.1016/j.apsb.2025.04.007
This new article publication from Acta Pharmaceutica Sinica B, discusses how a photodynamic nanohybrid system reverses hypoxia and augments anti-primary and metastatic tumor efficacy of immunotherapy.
Photodynamic immunotherapy is a promising strategy for cancer treatment. However, the dysfunctional tumor vasculature results in tumor hypoxia and the low efficiency of drug delivery, which in turn restricts the anticancer effect of photodynamic immunotherapy.
The ...
https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/15/issue/6
Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes ...
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