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SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts

2025-07-09
(Press-News.org) https://doi.org/10.1016/j.apsb.2025.04.017

This new article publication from Acta Pharmaceutica Sinica B, discusses how SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts.

 

Idiopathic pulmonary fibrosis (IPF), a chronic interstitial lung disease, is characterized by aberrant wound healing, excessive scarring and the formation of myofibroblastic foci. Although the role of alternative splicing (AS) in the pathogenesis of organ fibrosis has garnered increasing attention, its specific contribution to pulmonary fibrosis remains incompletely understood.

 

In this study, an up-regulation of serine/arginine-rich splicing factor 7 (SRSF7) was identified in lung fibroblasts derived from IPF patients and a bleomycin (BLM)-induced mouse model, and further characterized its functional role in both human fetal lung fibroblasts and mice.

 

It was demonstrated that enhanced expression of Srsf7 in mice spontaneously induced alveolar collagen accumulation. Mechanistically, alternative splicing events were investigated and revealed that SRSF7 modulates the alternative splicing of pyruvate kinase (PKM), leading to metabolic dysregulation and fibroblast activation.

 

In vivo studies showed that fibroblast-specific knockout of Srsf7 in conditional knockout mice conferred resistance to bleomycin-induced pulmonary fibrosis. Importantly, through drug screening, lomitapide was identified as a novel modulator of SRSF7, which effectively mitigated experimental pulmonary fibrosis.

 

Collectively, these findings elucidate a molecular pathway by which SRSF7 drives fibroblast metabolic dysregulation and propose a potential therapeutic strategy for pulmonary fibrosis.

 

Keywords: IPF, Alternative splicing, Splicing factor, SRSF7, PKM, Fibroblasts, Metabolism, Drug screening

 

Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S2211383525002746-ga1_lrg.jpg

SRSF7 regulates the alternative splicing of PKM, leading to dysregulation of glycolysis and activation of fibroblasts. This study highlights targeting the SRSF7–PKM axis as a promising therapeutic strategy for IPF.

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The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

 

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

 

Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).

 

CiteScore: 24.3

Impact Factor: 14.6 (Top 6 journal in the category of Pharmacology and pharmacy) 

JIF without self-citation: 13.8

 

ISSN 2211-3835

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Tongzhu Jin, Huiying Gao, Yuquan Wang, Zhiwei Ning, Danyang Bing, Yan Wang, Yi Chen, Xiaomu Tian, Qiudi Liu, Zhihui Niu, Jiayu Guo, Jian Sun, Ruoxuan Yang, Qianqian Wang, Shifen Li, Tianyu Li, Yuhong Zhou, Wenxin He, Yanjie Lu, Yunyan Gu, Haihai Liang, SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts, Acta Pharmaceutica Sinica B, Volume 15, Issue 6, 2025, Pages 3041-3058, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2025.04.017

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[Press-News.org] SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts