(Press-News.org) About The Study: In this cohort study, higher anticholinergic exposure was associated with accelerated decline in physical performance, consistent with clinically meaningful decline. These findings suggest that minimizing anticholinergic medications is important for healthy aging.
Corresponding Author: To contact the corresponding author, Shelly L. Gray, PharmD, MS, email slgray@uw.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2025.19819)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
# # #
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.19819?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071025
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
END
Cumulative anticholinergic exposure and change in gait speed and grip strength in older adults
JAMA Network Open
2025-07-10
ELSE PRESS RELEASES FROM THIS DATE:
Study suggests lemurs age differently than humans
2025-07-10
What can lemurs tell us about inflammation and aging, aka “inflammaging” in humans? That’s the question Elaine Guevara, a biological anthropologist who studies the evolution of life history and aging in primates, set out to understand.
In newly published research on age-related inflammation in ring-tailed and sifaka lemurs, Guevara discovered that perhaps we should rethink the inevitability of inflammaging in humans.
Although similar in many ways, ring-tailed and sifaka lemurs show differences in life pacing ...
Hypothermia alters glucose metabolism and may reveal mechanisms of metabolic disease
2025-07-10
Some mammals are capable of hibernating during periods of low food availability in an effort to conserve energy and survive. While it is easy to understand why species have evolved this survival mechanism, exactly how these animals regulate their metabolism and body temperature remains a mystery.
Researchers have known for decades that the lower body temperatures observed during hibernation go hand in hand with lower metabolism. The metabolism of glucose, a sugar commonly used to generate the energy used by cells, produces heat, and maintaining lower body ...
Content or form? The two possible paths of our memories
2025-07-10
If memories are the black box of our past, they can also shed light on the present by giving meaning to new situations. But how does memory retrieve either surface matches (based on same places, same people) or deeper, more conceptual ones (based on similar intentions or actions)? A team from the University of Geneva (UNIGE) has shed light on this question, showing that memory tends to favour the substance of a situation —its concept or underlying problem — when it can be linked to familiar mental ...
Research team produces low-loss spin waveguide network
2025-07-10
The rapid rise in AI applications has placed increasingly heavy demands on our energy infrastructure. All the more reason to find energy-saving solutions for AI hardware. One promising idea is the use of so-called spin waves to process information. A team from the Universities of Münster and Heidelberg (Germany) led by physicist Prof. Rudolf Bratschitsch (Münster) has now developed a new way to produce waveguides in which the spin waves can propagate particularly far. They have thus created the largest spin waveguide network to date. Furthermore, the group succeeded in specifically controlling the ...
PolyU-led research reveals that sensory and motor inputs help large language models represent complex concepts
2025-07-10
Can one truly understand what “flower” means without smelling a rose, touching a daisy or walking through a field of wildflowers? This question is at the core of a rich debate in philosophy and cognitive science. While embodied cognition theorists argue that physical, sensory experience is essential to concept formation, studies of the rapidly evolving large language models (LLMs)suggest that language alone can build deep, meaningful representations of the world.
By exploring the similarities between LLMs and human representations, researchers at The Hong ...
Premature babies should have early skin-to-skin contact with their mother
2025-07-10
More premature babies who had early skin-to-skin contact with their mother were being breastfed at the time of discharge from hospital and for up to one year afterwards. However, this is far from the only benefit.
A team from St. Olavs Hospital and the Norwegian University of Science and Technology (NTNU) have looked at this issue in a number of articles. They now hope that more hospitals will change their practice so that premature babies are not separated from their mother during the first few hours after birth.
“The first few ...
New research in JNCCN offers reassurance about localized prostate cancer prognosis
2025-07-10
PLYMOUTH MEETING, PA [July 10, 2025] — New research in the July 2025 issue of JNCCN—Journal of the National Comprehensive Cancer Network finds that for people diagnosed with nonmetastatic low-risk prostate cancer later in life, and treated according to NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), 90% were likely to survive their cancer for their remaining life-expectancy. Of those with nonmetastatic higher-risk cancer and a longer life expectancy, that likelihood was still greater than 65%.
The researchers studied 62,839 people diagnosed with non-metastatic prostate ...
Fluorinated polyimide: High toughness and low dielectric properties pave new path for high-frequency communication materials
2025-07-10
Conventional polyimides (PIs) exhibit excellent thermal stability and mechanical performance, yet their dielectric properties (dielectric constant (Dk) > 3.2, dissipation factor (Df) > 0.005 @ 10 GHz). In previous reports, the introduction of trifluoromethyl reduced the dielectric constant and dissipation factor, but it increased chain rigidity, weakened hydrogen bonds interaction, and reduced free volume, which definitely reduced mechanical performance (such as poor toughness leading to crack risks in advanced packaging). Therefore, it is necessary to design PI materials with high toughness and low dielectric properties to meet ...
Radar-based control of a helical microswimmer in 3-Dimensional space with dynamic obstacles
2025-07-10
Recent advances have yielded significant progress in actuation, navigation, and control of magnetic microrobots. Nevertheless, dynamic obstacle avoidance in 3D environments remains a critical challenge, often relying on computationally intensive path-planning methods that limit real-time performance. "Using a hierarchical radar system to enable high-frequency direction updates minimizes computational load while ensuring collision-free navigation," explained corresponding author Jiangfan Yu, a professor at The Chinese University of Hong Kong, Shenzhen. The radar framework comprises (a) a motion sphere for directional ...
Short-term physical activity reduces metabolic-associated steatohepatitis by promoting the degradation of branched-chain amino acids in skeletal muscle
2025-07-10
Background and Aims
Metabolic-associated steatohepatitis (MASH) is an advanced and progressive liver disease that potentially causes cirrhosis and hepatocellular carcinoma. Exercise is a crucial and effective intervention for ameliorating metabolic dysfunction-associated steatotic liver disease. This study aimed to provide a comprehensive understanding of the underlying mechanisms of MASH, which benefit a broad spectrum of MASH patients, including those who have difficulty engaging in physical activity.
Methods
We established a mouse model of MASH and selectively knocked down ...
LAST 30 PRESS RELEASES:
Media Tip Sheet: Symposia at ESA2025
NSF CAREER Award will power UVA engineer’s research to improve drug purification
Tiny parasitoid flies show how early-life competition shapes adult success
New coating for glass promises energy-saving windows
Green spaces boost children’s cognitive skills and strengthen family well-being
Ancient trees dying faster than expected in Eastern Oregon
Study findings help hone precision of proven CVD risk tool
Most patients with advanced melanoma who received pre-surgical immunotherapy remain alive and disease free four years later
Introducing BioEmu: A generative AI Model that enables high-speed and accurate prediction of protein structural ensembles
Replacing mutated microglia with healthy microglia halts progression of genetic neurological disease in mice and humans
New research shows how tropical plants manage rival insect tenants by giving them separate ‘flats’
Condo-style living helps keep the peace inside these ant plants
Climate change action could dramatically limit rising UK heatwave deaths
Annual heat-related deaths projected to increase significantly due to climate and population change
Researchers discover new way cells protect themselves from damage
Rivers choose their path based on erosion — a discovery that could transform flood planning and restoration
New discovery reveals dopamine operates with surgical precision, not as a broad signal
New AI tool gives a helping hand to x ray diagnosis
New Leicester study reveals hidden heart risks in women with Type 2 Diabetes
Over 400 different types of nerve cell have been grown – far more than ever before
Newly discovered molecule may explain reduced muscle mass in type 2 diabetes
Rheumatoid arthritis and muscle wasting: New review points to overlooked complications
Overcoming intrinsic dispersion locking by misaligned bilayer metagratings
Vaccines work: Cohort data from Denmark show real-world evidence of stable protection against HPV-related cervical cancer
Underwater shaped charge explosions: a comprehensive experimental study on coupling dynamics
Wristband sensor provides all-in-one monitoring for diabetes and cardiovascular care
Unveiling the spatiotemporal landscape of Ganoderma lingzhi: insights into ganoderic acid distribution and biosynthesis
Quality and antibiotic resistance risks in livestock probiotics in China
Genomic study reveals deep roots of human survival and adaptation in Himalayas
Differential obesity trends in Asian and Native Hawaiian or other Pacific Islander US adults
[Press-News.org] Cumulative anticholinergic exposure and change in gait speed and grip strength in older adultsJAMA Network Open