(Press-News.org) https://doi.org/10.1016/j.apsb.2025.05.013
This new article publication from Acta Pharmaceutica Sinica B, discusses how single-cell RNA sequencing reveals that Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells.
Colorectal tumorigenesis generally progresses from adenoma to adenocarcinoma, accompanied by dynamic changes in the tumor microenvironment (TME). A randomized controlled trial has confirmed the efficacy and safety of Shen-Bai-Jie-Du decoction (SBJDD) in preventing colorectal tumorigenesis. However, the mechanism remains unclear. In this study, single-cell RNA sequencing (scRNA-seq) was employed to investigate the dynamic evolution of the TME and validated cell infiltration with multiplex immunohistochemistry and flow cytometry. Bulk RNA sequencing was utilized to assess the underlying mechanisms. The results constructed the mutually verifiable single-cell transcriptomic atlases in ApcMin/+ mice and clinical patients. There was a marked accumulation of CCL22+ dendritic cells (DCs) and an enhanced immunosuppressive action, which SBJDD and berberine reversed. Combined treatment with cholesterol and lipopolysaccharide induced characteristic gene expression of CCL22+ DCs, which may represent “exhausted DCs”. Intraperitoneal injection of these DCs after SBJDD treatment eliminated its therapeutic effects. TMEM131 derived CCL22+ DCs generation by TNF signaling pathway and may be a potential target of berberine in retarding colorectal tumorigenesis. These findings emphasize the role of exhausted DCs and the regulatory mechanisms of SBJDD and berberine in colorectal cancer (CRC), suggesting that the multi-component properties of SBJDD may help restore TME homeostasis and offer novel cancer therapy.
Keywords: Single-cell RNA sequencing, Colorectal tumorigenesis, Tumor microenvironment, Traditional Chinese medicine, CCL22+ dendritic cells, CD4+ regulatory T cells, TMEM131, TNF signaling pathway
Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S221138352500320X-ga1_lrg.jpg
Single-cell RNA sequencing in ApcMin/+ mice and clinical specimens demonstrates that Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by regulating TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells.
# # # # # #
The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/
Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board
APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).
Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).
CiteScore: 24.3
Impact Factor: 14.6 (Top 6 journal in the category of Pharmacology and pharmacy)
JIF without self-citation: 13.8
ISSN 2211-3835
# # # # #
Yuquan Tao, Yinuo Ma, Limei Gu, Ye Zhang, Qinchang Zhang, Lisha Zhou, Jie Pan, Meng Shen, Xuefei Zhuang, Linmei Pan, Weixing Shen, Chengtao Yu, Dan Dong, Dong Zhang, Tingsheng Ling, Yang Sun, Haibo Cheng, Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells, Acta Pharmaceutica Sinica B, Volume 15, Issue 7, 2025, Pages 3545-3560, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2025.05.013
END
https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/15/issue/7
Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes ...
In a first for the field, researchers from The Grainger College of Engineering at the University of Illinois Urbana-Champaign have reported a photopumped lasing from a buried dielectric photonic-crystal surface-emitting laser emitting at room temperature and an eye-safe wavelength. Their findings, published in IEEE Photonics Journal, improve upon current laser design and open new avenues for defense applications.
For decades, the lab of Kent Choquette, professor of electrical and computer engineering, have explored VCSELs, a type of surface-emitting laser used in common technology like smartphones, laser printers, barcode scanners, and even vehicles. But ...
A new study led by investigators from Mass General Brigham trialed stereotactic (targeted) brain-directed radiation in 100 patients with small cell lung cancer and brain metastases, finding they experienced positive outcomes that support use of targeted radiation in the future for such patients. Results are published in the Journal of Clinical Oncology.
“Despite being the historical standard, whole brain radiation might not be necessary for all patients,” said first author Ayal Aizer, MD, MHS, director of Central Nervous System Radiation Oncology at Brigham and Women’s Hospital, a founding member of the ...
https://doi.org/10.1016/j.apsb.2025.04.020
This new article publication from Acta Pharmaceutica Sinica B, discusses a high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers.
An ideal dermal filler should integrate filling, repair, and anti-aging effects, with immediate tissue augmentation, slow degradation, and progressive stimulation of collagen regeneration. However, commonly used hyaluronic ...
A traditionally overlooked type of RNA plays an important role in promoting resilience to depression—but only in females. According to a new study led by the Icahn School of Medicine at Mount Sinai, researchers have now discovered a novel role this molecule plays in how the female brain makes decisions. The authors revealed brain-region-specific and sex-dependent effects of this biomarker, translated from humans to animals, on how individuals make only certain types of choices. This study uncovered ...
Analyzed 174 donated brains, including from former high school, college football players
Larger studies needed to understand how p-tau relates to aging and the extent to which repetitive impact from contact sport predisposes to p-tau accumulation
Whether such changes cause or are associated with clinical problems during life remains unclear
CHICAGO --- In recent years, some scientists and advocates have warned that playing contact sports like football and hockey may increase the risk of brain diseases like Alzheimer’s disease or chronic traumatic encephalopathy (CTE) due to a buildup of a specific protein in the brain.
But a new ...
An international research team led by Freiburg biologists Dr. Wenjing Qi and Prof. Ralf Baumeister has discovered how the LINE1 retrotransposon exploits a cell protein to become active itself, as occurs in tumours. At the same time, the researchers have also deciphered the cell's appropriate countermeasure to prevent conditions such as tumour formation or chronic inflammation. The results have been published in the journal Nature Communications.
Cellular sleepers
"Sleepers" are the name the Secret Service gives agents who live inconspicuously in ...
LA JOLLA, CA—A new microchip invented by Scripps Research scientists can reveal how a person’s antibodies interact with viruses—using just a drop of blood. The technology offers researchers faster, clearer insights that could help accelerate vaccine development and antibody discovery.
“This lets us take a quick snapshot of antibodies as they are evolving after a vaccine or pathogen exposure,” says Andrew Ward, professor in the Department of Integrative Structural and Computational Biology at Scripps Research and senior author of the new paper published ...
Why do some communities unite in times of crisis, while others fall apart? The study of Kaunas University of Technology researchers revealed a surprising link – cultural heritage is not just a historical asset, but also a powerful tool that helps people build a sense of belonging and act collectively when challenges arise.
Along with trust and emotional attachment to place, it becomes a foundation for communities to care for their environment, maintain relationships, and respond to crises together.
“A resilient community is a group of people who can unite, ...
For decades, the story of Alzheimer’s research has been dominated by a battle between A-beta and tau amyloids, both of which can kill neurons and impact the brain’s ability to function. A new study suggests, however, that these sticky brain plaques may not be operating alone.
Johns Hopkins University researchers have identified more than 200 types of misfolded proteins in rats that could be associated with age-related cognitive decline.
The findings could lead the way to finding new therapeutic targets and treatments in humans that could provide relief for the millions of people over 65 who suffer from Alzheimer’s, ...
