Prevalence of extremely severe obesity and metabolic dysfunction among US children and adolescents

JAMA Network Open

2025-07-16

(Press-News.org) About The Study: In this nationally representative cross-sectional study of U.S. children and adolescents, prevalence of extremely severe obesity significantly increased over time, particularly among older adolescents and non-Hispanic Black participants. Extremely severe obesity was associated with severe metabolic and cardiovascular complications, including metabolic dysfunction–associated steatotic liver disease, prediabetes or diabetes, severe insulin resistance, and metabolic syndrome. These findings emphasize the urgent need for public health interventions and policies to address pediatric obesity broadly.

Corresponding Author: To contact the corresponding author, Phillipp Hartmann, MD, MAS, email phhartmann@health.ucsd.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.21170)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.21170?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=071625

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Estimated burden of influenza and direct and indirect benefits of influenza vaccination

2025-07-16

About The Study: In this analytical model study, influenza vaccination provided substantial benefit in reducing infections to both the vaccinated and unvaccinated portions of the population. Even when both vaccine effectiveness and vaccine uptake were low, vaccination showed marked reductions in disease burden for transmission levels characteristic of seasonal influenza. However, when the level of transmission was very high, even a highly effective vaccine did not protect unvaccinated individuals. These findings underscore the importance of vaccination in disease prevention and ...

Projected health system and economic impacts of 2025 Medicaid policy proposals

2025-07-16

About The Study: This analysis indicates that proposed Medicaid reforms would have far-reaching consequences beyond federal budget savings, including negative health outcomes, economic losses, and health care system disruptions, with rural and underserved communities disproportionately affected. Corresponding Author: To contact the corresponding author, Sanjay Y. Basu, MD, PhD, email sanjay.basu@ucsf.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamahealthforum.2025.3187) Editor’s Note: Please see the article for additional information, including ...

New tech for imaging brain waves could advance disease research, AI

2025-07-16

When electrical activity travels across the brain, it moves like ripples on a pond. The motion of these “brain waves,” first observed in the 1920s, can now be seen more clearly than ever before thanks to instruments and techniques created by a Stanford-led team. The technology, described in the journal Cell, involves two ultra-sensitive optical instruments that can detect signals of genetically engineered proteins, known as “voltage indicators,” revealing neuronal brain wave activity in mice. While limited to research animals, the advance has already shown its potential. Using these instruments, the researchers ...

Immigrants in U.S. earn 10.6% less than native-born workers, but biggest driver is job access, not wage discrimination

2025-07-16

AMHERST, Mass. — Immigrants in the United States earn 10.6% less than similarly educated U.S.-born workers, largely because they are concentrated in lower-paying industries, occupations and companies, according to a major new study published today in Nature, co-authored by a University of Massachusetts Amherst sociologist who studies equal opportunity in employment. The research—one of the most comprehensive global comparisons of immigrant labor market integration to date—analyzes linked employer-employee ...

New peer-reviewed study reveals severe health and economic consequences of 2025 Medicaid policy changes

2025-07-16

Waymark, a public benefit company dedicated to improving access and quality of care in Medicaid, today published peer-reviewed research in JAMA Health Forum examining the projected health system and economic impacts of 2025 Medicaid policy changes. The study, conducted in collaboration with researchers at the University of North Carolina at Chapel Hill, reveals that H.R. 1, the "One Big Beautiful Bill Act" recently passed by Congress, could result in devastating consequences for vulnerable populations, rural communities, and local economies nationwide. Numerous studies from multiple organizations, including the nonpartisan ...

Faster, smarter, more open: a new way to accelerate AI models

2025-07-16

Just as people from different countries speak different languages, AI models also create various internal “languages” – a unique set of tokens understood only by each model. Until recently, there was no way for models developed by different companies to communicate directly, collaborate or combine their strengths to improve performance. This week, at the International Conference on Machine Learning (ICML) in Vancouver, Canada, scientists from the Weizmann Institute of Science and Intel Labs are presenting a ...

What does it cost an animal to fight?

2025-07-16

How do animals decide when to fight and when to walk, fly, slither, or swim away? Most research on animal conflict has focused on the short-term costs of single interactions, but a pair of behavioral ecologists argue that these one-time events might paint an incomplete picture. In an opinion paper publishing July 16 in the Cell Press journal Trends in Ecology & Evolution, the researchers say that to really understand the consequences of animal conflict, we need to also consider its long-term and cumulative impact on an individual’s longevity and reproduction. “By linking individual contests to lifetime reproductive success, we ...

Discovery could battle Alzheimer’s by boosting blood flow to brain

2025-07-16

New University of Virginia School of Medicine research suggests an unexpected way doctors may be able to improve blood flow to the brain to battle Alzheimer’s and other neurodegenerative diseases. Scientists led by Ukpong B. Eyo, PhD, of UVA’s Department of Neuroscience, found that immune cells called microglia play an essential role in determining how well tiny capillaries deliver blood and essential nourishment to our brains. The scientists believe problems with these microglia could be contributing to failing brain health, and targeting them could help us prevent or reverse memory-stealing diseases caused or worsened by lack of adequate blood flow. This could include Alzheimer’s, ...

New antibody selectively targets immune cells that suppress anti-tumor responses

2025-07-16

“Taken together, our studies suggest that 2B010 represents an anti-CD25 mAb with unique properties in that it deleted Treg from an inflammatory environment (GVHD) as well as from the TME.” BUFFALO, NY – July 16, 2025 – A new research paper was published in Volume 16 of Oncotarget on July 9, 2025, titled “A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment.” In this study, researchers from the National Institute of Allergy and Infectious Diseases, led by first author Maja ...

OHSU scientists develop tool that improves tissue cancer analysis

2025-07-16

Researchers have developed a powerful new tool that makes it easier to study the mix of cell types in human tissue, which is crucial for understanding diseases such as cancer. Developed by researchers at Oregon Health & Science University’s Knight Cancer Institute, the tool, dubbed OmicsTweezer, uses advanced machine learning techniques to analyze biological data at a scale large enough to estimate the composition of cell types in a sample of tissue that may be taken from a biopsy. This process allows scientists to map the cellular makeup of tumors and surrounding tissues — an area ...

Prevalence of extremely severe obesity and metabolic dysfunction among US children and adolescents

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: