PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Comprehensive multi-omics integration reveals B cell-derived ELL2 as a novel diagnostic and prognostic biomarker in sepsis

2025-07-18
(Press-News.org) Sepsis is a life-threatening condition caused by organ dysfunction resulting from the body's dysregulated response to infection. Annually, sepsis affects more than 31 million people worldwide, with a mortality rate of approximately 30%. The disease is characterized by rapid progression, poor prognosis, and high mortality, posing significant challenges in critical care medicine. Early diagnosis and intervention are crucial for improving patient outcomes. In a study published in the journal "Med Research," a team of researchers from China outlined their discovery of new sepsis patient subtypes and identified elevated expression of the B cell-derived ELL2 gene as a novel biomarker. This finding brings hope for addressing the limitations of current clinical diagnostic tests, improving early diagnosis, and enhancing patient outcomes in sepsis management.

Dr. Wang Xuan, the first author of the study from Hebei Medical University, explained: "Recent advances in transcriptomics, proteomics, and metabolomics have made the identification of reliable biomarkers possible. With the emergence of bioinformatics, multiple studies have employed advanced machine learning methods to develop sepsis diagnostic models, improving patient identification capabilities. While existing biomarkers are useful, they have limitations such as insufficient sensitivity or specificity, leading to suboptimal treatment timing and increased mortality in sepsis patients. Therefore, there is an urgent need for new biomarkers that can accurately predict prognosis and diagnose sepsis."

The research team analyzed bulk RNA sequencing data from 10 sepsis patient cohorts. Through unbiased patient clustering, they identified three subtypes with significantly different prognoses, which were consistently reproduced across all 10 cohorts. Through comprehensive multi-dimensional analysis, they revealed distinct differences among the subtypes in terms of inflammation, immune response, and functional pathways. By integrating multiple machine learning algorithms and single-cell transcriptomic analysis, they ultimately identified ELL2 as an effective diagnostic and prognostic biomarker for sepsis. This study provides new insights into the potential mechanisms of sepsis progression and emphasizes the importance of continuous monitoring of ELL2 expression during early diagnosis and treatment.

Dr. Ning Jingyuan, who led this research, believes this represents a major breakthrough in sepsis early warning and biomarker research. "Current studies are limited by small sample sizes and poor reproducibility bottlenecks, and new biomarkers must be validated in multicenter cohorts." He added: "We hope that our study spanning 10 cohorts can provide new perspectives and therapeutic strategies for timely treatment of sepsis patients.

END


ELSE PRESS RELEASES FROM THIS DATE:

How tumor microbes shape cancer: New insights into microbial diversity in the tumor microenvironment

2025-07-18
Intratumoral microbiota—the microbial populations residing within solid tumors—have emerged as pivotal components of the tumor microenvironment (TME), influencing tumor initiation, progression, and therapeutic outcomes. In a comprehensive review published in Med Research, researchers from Southern Medical University and collaborating institutions systematically examine the heterogeneity of these microorganisms and their multifaceted roles in cancer biology. The authors categorize microbial heterogeneity at three distinct levels: among different ...

AI-powered biomarker system redefines thyroid cancer progression and subtypes

2025-07-18
Differentiated thyroid carcinoma (DTC) is typically indolent, and some patients may be managed conservatively without immediate surgery. However, it remains a clinical challenge to determine who is suitable for active surveillance and to identify when disease progression may occur. A new study led by researchers at The First Affiliated Hospital of Zhengzhou University addresses this issue by developing an innovative dynamic biomarker system. Using an optimized dynamic network biomarker (DNB) algorithm, the team identified ...

Digestive cancers in China: A two-decade burden with uneven gains in life expectancy

2025-07-18
Digestive system malignancies (DSMTs)—including oesophageal, gastric, colorectal, liver, and pancreatic cancers—represent a major public health challenge in China. A recent national epidemiological study by Hu et al., published in eGastroenterology, analysed trends from 2004 to 2021, revealing complex patterns of burden and survival. While progress has been made in reducing mortality from some cancers, the overall impact remains significant, with notable disparities across demographic and geographic lines. Below ...

ANXA2+ migratory hepatocytes identified as key players in human liver regeneration

2025-07-18
Acute liver failure (ALF) represents a life-threatening condition marked by rapid deterioration of liver function, often necessitating urgent liver transplantation. In the United States, acetaminophen (APAP) overdose remains the most common cause of drug-induced ALF, accounting for nearly half of all cases. Given the scarcity of viable donor livers—worsened by the prevalence of steatotic liver disease—understanding and promoting the liver's intrinsic regenerative capacity has become an urgent priority ...

Researchers demonstrate a new material to reduce power consumption of electronics

2025-07-18
MINNEAPOLIS / ST. PAUL (07/18/2025) — Research from the University of Minnesota Twin Cities gives new insight into a material that could make computer memory faster and more energy-efficient. The study was recently published in Advanced Materials, a peer-reviewed scientific journal. The researchers also have a patent on the technology. As technology continues to grow, so does the demand for emerging memory technology. Researchers are looking for alternatives and complements to existing memory solutions that can perform at high levels with ...

New chemical tool may improve development of key drug components

2025-07-18
COLUMBUS, Ohio – Chemists have developed a novel way to generate a variety of highly useful chemical building blocks by harnessing metal carbenes, suggests new research.   Typically used in chemical reactions essential for drug synthesis and materials development, carbenes are short-lived, highly reactive carbon atoms. In the lab, this can make carbenes especially tricky to create, as methods to form them are limited and often hazardous.  Now, for the first time, an approach discovered by researchers at The Ohio State University has made producing these ...

IEEE study achieves efficient integration of quantum dot lasers on silicon chiplets

2025-07-18
Lasers that are fabricated directly onto silicon photonic chips offer several advantages over external laser sources, such as greater scalability. Furthermore, photonic chips with these “monolithically” integrated lasers can be commercially viable if they can be manufactured in standard semiconductor foundries. III-V semiconductor lasers can be monolithically integrated with photonic chips by directly growing a crystalline layer of laser material, such as indium arsenide, on silicon substrate. However, photonic chips with such integrated laser source are challenging to manufacture due ...

Researchers discover that sound stress alone can prolong and intensify pain

2025-07-18
Pain is an important physiological response in living organisms. While physical pain is an outcome of tissue damage, pain can manifest as diverse unpleasant sensory and emotional experiences. Many studies report that emotional or psychological stress enhances pain responses. Furthermore, mice housed with other mice experiencing inflammatory pain exhibit a ‘bystander effect’ with heightened pain sensitivity, or ‘hyperalgesia.’ However, the effects that underpin social pain transmission remain elusive.  Rodents emit ultrasonic vocalizations in the form of high-pitched squeaks in response to various stimuli, including pain, in ...

Less pain, more gain: A new recipe for safer, stronger mRNA vaccines

2025-07-18
As millions of people know firsthand, the most common side effect of mRNA vaccines like the COVID-19 shot is inflammation: soreness, redness and a day or two of malaise. But what if mRNA vaccines could be redesigned to sidestep that response altogether? In a new paper in Nature Biomedical Engineering, researchers at the University of Pennsylvania show that tweaking the structure of the ionizable lipid, a key component of the lipid nanoparticles (LNPs) that deliver mRNA, not only reduces inflammation but also boosts vaccine effectiveness for preventing or treating a range of diseases, from COVID-19 to cancer. The ...

Surprising finding could pave way for universal cancer vaccine

2025-07-18
An experimental mRNA vaccine boosted the tumor-fighting effects of immunotherapy in a mouse-model study, bringing researchers one step closer to their goal of developing a universal vaccine to “wake up” the immune system against cancer. Published today in Nature Biomedical Engineering, the University of Florida study showed that like a one-two punch, pairing the test vaccine with common anticancer drugs called immune checkpoint inhibitors triggered a strong antitumor response. A surprising element, researchers said, was that they achieved the promising results not by attacking a specific target protein expressed in the tumor, but by simply revving ...

LAST 30 PRESS RELEASES:

Current and recommended diets in the USA have embedded forced labor risk

AI breakthrough helps astronomers spot cosmic events with just a handful of examples

New vaccine shows promise against typhoid and invasive salmonella in first human trial

Engineered “natural killer” cells could help fight cancer

New 3D printing method ‘grows’ ultra-strong materials

Lizard genetics provide new perspective on evolution

Can a Stevia-derived sweetener improve hair loss treatment?

Method to assess the status of wild reindeer may help with conservation efforts

Do imported cut flowers spread livestock viruses?

Does prior incarceration contribute to poor health later in life?

Could slime mold microbes be a source of potent antimicrobials?

Record-breaking 2024 Amazon fires drive unprecedented carbon emissions and ecosystem degradation

Birds thrive despite pollution from ‘forever’ chemicals

Deadwood brings wild orchids to life

Changes in gut microbiota influence which patients get AIG-related neuroendocrine tumors

Medicaid expansion linked to improved long-term survival in cancer patients

Women with surgical menopause may exit workforce earlier, but hormone therapy could help

Trailblazing Young Scientists honored with $250,000 prizes at Blavatnik National Awards Gala

Revolutionary blood test for ME / Chronic Fatigue unveiled

Calorie labelling linked to 2% average reduction in energy content of menu items

Widely prescribed opioid painkiller tramadol not that effective for easing chronic pain

Exercise snacks may boost cardiorespiratory fitness of physically inactive adults

15,000 women a year with breast cancer could benefit from whole genome sequencing, say researchers

Study highlights risks of Caesarean births to future pregnancies

GLP-1 agonists pose emerging challenge for PET-CT imaging, study finds

Scripps Research scientists unlock new patterns of protein behavior in cell membranes

Panama Canal may face frequent extreme water lows in coming decades

Flash Joule heating lights up lithium extraction from ores

COMBINEDBrain and MUSC announce partnership to establish biorepository for pediatric cerebrospinal fluid and CNS tissue bank

Questionable lead reporting for drinking water virtually vanished after Flint water crisis, study reveals

[Press-News.org] Comprehensive multi-omics integration reveals B cell-derived ELL2 as a novel diagnostic and prognostic biomarker in sepsis