Influenza-associated acute necrotizing encephalopathy in US children

JAMA

2025-07-30

(Press-News.org) About The Study: In this case series of children with influenza-associated acute necrotizing encephalopathy from the 2 most recent influenza seasons in the U.S., the condition was associated with high morbidity and mortality in this cohort of predominantly young and previously healthy children. The findings emphasize the need for prevention, early recognition, intensive treatment, and standardized management protocols.

Corresponding Author: To contact the corresponding author, Andrew Silverman, MD, MHS, email Aesilver@stanford.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2025.11534)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

About The Editorial: Timothy M. Uyeki, MD, MPH, MPP, of the Centers for Disease Control and Prevention, wrote about the study in an Editorial.

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Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.11534?guestAccessKey=cf976c38-c219-4f1e-968a-5728eafd28e6&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=073025

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Influenza-associated acute necrotizing encephalopathy in US children

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