Demographics, lifestyle, comorbidities, prediabetes, and mortality

JAMA Network Open

2025-08-07

(Press-News.org) About The Study: Stratified analyses in this study revealed that prediabetes was significantly associated with mortality only among younger adults (ages 20-54), highlighting the importance of age-specific interventions. Lifestyle behaviors, limited health care access, and life stage challenges may contribute to the increased mortality risk in younger adults. Early-onset health problems in this group may also reflect stronger genetic predispositions, leading to more rapid disease progression and more severe health outcomes. These findings underscore the need for tailored diabetes prevention programs targeting young adults—such as flexible, virtual, and peer-led options—to increase accessibility and engagement. Routine screening and timely referrals to age-appropriate programs are essential.

Corresponding Author: To contact the corresponding author, Leonard E. Egede, MD, MS, email legede@buffalo.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.26219)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Demographics, lifestyle, comorbidities, prediabetes, and mortality

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