New Study identifies early signs of valve failure one year after TAVI, raising durability concerns in younger patients
2025-08-18
(Press-News.org) A new study published in The Annals of Thoracic Surgery, a journal from The Society of Thoracic Surgeons, has identified early hemodynamic valve deterioration (HVD) in more than 6% of patients just one year after undergoing transcatheter aortic valve implantation (TAVI), raising new questions about valve durability in younger, lower-risk populations.
The retrospective study, which analyzed 10 years of procedures from 2012 to 2022, evaluated 2,123 patients who had complete echocardiographic follow-up data. Researchers found that patients with 1-year HVD were more likely to be younger and have smaller aortic annuli than those without HVD. Importantly, smaller implanted valve sizes were significantly associated with the development of HVD, while larger valves appeared to be protective.
“As TAVI is increasingly used in younger and healthier patients, our findings suggest a need to carefully consider valve sizing and long-term durability,” said lead study author Eishan Ashwat, BS, a medical student at the University of Pittsburgh School of Medicine. “Early identification of hemodynamic deterioration may serve as a key predictor of future reintervention and patient outcomes.”
According to the study, patients with 1-year HVD had a five-year aortic valve reintervention rate nearly four times higher than those without HVD (2.3% vs. 0.6%). Prior surgical aortic valve replacement (AVR) was also independently associated with a higher risk of early HVD.
The findings underscore the importance of vigilant long-term follow-up and may influence future decision-making regarding valve selection, particularly in patients with smaller aortic anatomy or a history of AVR.
The study used the updated Valve Academic Research Consortium-3 (VARC-3) definitions to assess bioprosthetic valve function and structural deterioration.
Read the full article here.
# # #
About The Annals of Thoracic Surgery
The Annals of Thoracic Surgery is the leading journal in cardiothoracic surgery, publishing cutting-edge research on innovations, techniques, and outcomes that shape the field of thoracic and cardiovascular surgery worldwide.
About The Society of Thoracic Surgeons
The Society of Thoracic Surgeons is a not-for-profit organization representing over 7,800 surgeons, researchers, and allied healthcare professionals worldwide who are committed to improving outcomes for patients undergoing cardiothoracic surgery.
END
ELSE PRESS RELEASES FROM THIS DATE:
2025-08-18
Just as smart traffic management ensures smooth vehicular movement during peak hours, our body relies on a molecular traffic system to manage the surge in glucose levels after a meal. Pancreatic β-cells play a major role in this system by taking up glucose from the blood and triggering insulin release into the bloodstream. Inside these cells, glucose uptake is managed by glucose transporters (GLUTs) – proteins that move to the β-cell surface when blood glucose levels rise and facilitate the entry of glucose into the cell ...
2025-08-18
With a $1 million Impact Award from the U.S. Department of Defense, Tianfu Wu, a University of Houston biomedical engineer, is developing a method to send medication directly to the spleen where certain immune cells cause the disease known as lupus, or Systemic Lupus Erythematosus.
Lupus is a debilitating autoimmune disease characterized by uncontrolled disease activity, frequent flares, long-term immunosuppression, increasing infection rates, cumulative organ damage and decreased quality of life.
The spleen has often been called the security guard of the bloodstream, filtering out old or damaged blood cells while housing millions of white blood cells, or lymphocytes, that carry ...
2025-08-18
Innovative intervention delivered by trained community health workers – meaning nonclinical personnel with deep knowledge of the community – increased treatment utilization among participating families with children who have ADHD, according to a pilot study published in the Journal of Attention Disorders. This intervention for parents and caregivers, covering topics that range from education about ADHD to discussions of stigma and barriers to care, intends to reduce inequities in access to evidence-based treatment and boost family engagement in ADHD care.
“We know from previous studies that compared to White youth, Black, Hispanic, and Asian ...
2025-08-18
Zhengang Lu and Russell Epstein, from the University of Pennsylvania, led a study to explore how people maintain their sense of direction while navigating naturalistic, virtual reality cities.
As reported in their new JNeurosci paper, the researchers collected neuroimaging data while 15 participants performed a taxi driving task in a virtual reality city. Two brain regions represented forward-facing direction as people moved around. This neural signal was consistent across variations of the city with different visual features. The signal was also ...
2025-08-18
COLUMBUS, Ohio – When it comes to adopting artificial intelligence in high-stakes settings like hospitals and airplanes, good AI performance and a brief worker training on the technology is not sufficient to ensure systems will run smoothly and patients and passengers will be safe, a new study suggests.
Instead, algorithms and the people who use them in the most safety-critical organizations must be evaluated simultaneously to get an accurate view of AI’s effects on human decision making, researchers say.
The team also contends these evaluations should assess how people respond to good, mediocre and poor technology performance ...
2025-08-18
The American Geriatrics Society (AGS) has released a landmark update to its list of alternatives to medications listed in the 2023 AGS Beers Criteria® — the most widely adopted guidelines to help clinicians identify potentially inappropriate medications for older adults. This new effort delivers not only a comprehensive suite of safer pharmacologic options, but also a strong emphasis on effective non-pharmacologic treatments for common conditions impacting frail and aging populations.
The AGS panel is comprised of 19 national experts from 14 states, ...
2025-08-18
When health secretary Robert F. Kennedy Jr. recently fired an entire federal vaccine advisory panel, he described the unprecedented move as necessary to rid the committee of industry influence.
However, new research from the USC Schaeffer Center for Health Policy & Economics finds that reported conflicts on that Centers for Disease Control and Prevention panel had been at historic lows for years before Kennedy’s abrupt dismissal. Furthermore, the type of conflict typically considered the most concerning—income ...
2025-08-18
About The Study: Among patients with severe chronic rhinosinusitis with nasal polyps treated with a daily intranasal corticosteroid, stapokibart, a novel monoclonal antibody, reduced polyp size and severity of nasal symptoms at 24 weeks.
Corresponding Authors: To contact the corresponding authors, email Luo Zhang, MD, (dr.luozhang@139.com) and Chengshuo Wang, MD, (wangcs830@126.com).
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jama.2025.12515)
Editor’s Note: Please see the article for additional information, including other authors, author contributions ...
2025-08-18
A new study reports evidence of a link between prenatal exposure to the widely used insecticide chlorpyrifos (CPF) and structural abnormalities in the brain and poorer motor function in New York City children and adolescents.
The findings are the first to demonstrate enduring and widespread molecular, cellular, and metabolic effects in the brain, as well as poorer fine motor control among youth with prenatal exposure to the insecticide. The study by researchers at Columbia University Mailman School of Public Health, Children’s ...
2025-08-18
About The Study: Study participants with hearing loss with hearing aids showed reduced risk for dementia among those younger than age 70 at the time of hearing evaluation, when followed up for up to 20 years. This finding highlights the importance of early intervention for hearing loss for possible prevention of dementia.
Corresponding Author: To contact the corresponding author, Sudha Seshadri, M.D., email seshadri@uthscsa.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi: 10.1001/jamaneurol.2025.2713)
Editor’s Note: Please see the article for additional information, including ...
LAST 30 PRESS RELEASES:
[Press-News.org] New Study identifies early signs of valve failure one year after TAVI, raising durability concerns in younger patients
