PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Integrated analysis of serum and fecal metabolites reveals the role of bile acid metabolism in drug-induced liver injury: Implications for diagnostic and prognostic biomarkers

2025-08-20
(Press-News.org) Background and Aims Drug-induced liver injury (DILI) represents a prevalent adverse event associated with medication use. However, the exact mechanisms underlying DILI remain incompletely understood, and the lack of specific diagnostic and prognostic biomarkers poses significant challenges to the clinical diagnosis and treatment of this condition. Consequently, our study aimed to endeavor to identify serum and fecal metabolic biomarkers, enabling more accurate DILI diagnosis and improved prediction of chronic progression.

Methods Untargeted metabolomics analysis was performed on serum and fecal samples obtained from a cohort of 32 DILI patients (causality confirmed via the updated Roussel Uclaf Causality Assessment Method) and 36 healthy controls. Utilizing techniques such as partial least squares-discriminant analysis modeling and t-tests, we identified significantly differentially expressed metabolites and metabolite sets. Causality assessment was performed using the updated Roussel Uclaf Causality Assessment Method.

Results The findings from the analysis of serum and fecal metabolomics association pathways suggested that perturbations in bile acid metabolism might serve as potential mechanisms underlying the progression of DILI. Our study revealed 22 overlapping differential metabolites between serum and feces, displaying significant concentration differences between the DILI and healthy control groups. Notably, we identified chenodeoxycholic acid and deoxycholic acid as promising markers that not only distinguished DILI patients from healthy individuals but also exhibited predictive potential for DILI chronicity.

Conclusions Future studies incorporating such control groups would help clarify the causal role of drug administration in bile acid dysregulation and improve the specificity of biomarker identification. Although further validation is warranted, these metabolic signatures may provide complementary value for the early diagnosis and prognostic prediction of DILI. Future directions include multicenter, large-scale cohort studies to validate biomarker specificity, comparative metabolomic analyses across different liver diseases (e.g., viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease), and integrative multi-omics approaches to elucidate DILI-specific regulatory networks and enhance clinical applicability.

 

Full text

https://www.xiahepublishing.com/2310-8819/JCTH-2025-00073

 

The study was recently published in the Journal of Clinical and Translational Hepatology.

The Journal of Clinical and Translational Hepatology (JCTH) is owned by the Second Affiliated Hospital of Chongqing Medical University and published by XIA & HE Publishing Inc. JCTH publishes high quality, peer reviewed studies in the translational and clinical human health sciences of liver diseases. JCTH has established high standards for publication of original research, which are characterized by a study’s novelty, quality, and ethical conduct in the scientific process as well as in the communication of the research findings. Each issue includes articles by leading authorities on topics in hepatology that are germane to the most current challenges in the field. Special features include reports on the latest advances in drug development and technology that are relevant to liver diseases. Regular features of JCTH also include editorials, correspondences and invited commentaries on rapidly progressing areas in hepatology. All articles published by JCTH, both solicited and unsolicited, must pass our rigorous peer review process.

Follow us on X: @xiahepublishing

Follow us on LinkedIn: Xia & He Publishing Inc.

END



ELSE PRESS RELEASES FROM THIS DATE:

Industrial pollution’s imprint lasts generations

2025-08-20
In a groundbreaking study, University of Utah researchers found strong evidence that exposure to industrial pollution during pregnancy can shape a grandchild’s neurodevelopment. A child has a higher risk of an intellectual disability if their grandmothers lived near industrial facilities while pregnant with a parent, especially the mother. Higher density of industrial facilities corresponded to higher risk for the grandchild. “We know that breathing polluted air is dangerous for our own health now, but it’s ...

15 students named national Youth Heart Ambassadors for 2025-26 school year

2025-08-20
DALLAS, Aug. 20, 2025 — With young Americans facing rising rates of mental and physical health challenges[1], the American Heart Association, a relentless force changing the future of health for everyone everywhere, is enlisting a new class of Youth Heart Ambassadors to spark change in schools and communities nationwide. The Association selected 15 first through 12th grade students from across the country as national Youth Heart Ambassadors for the 2025-26 school year. Representing the Association’s Kids Heart Challenge™ and American Heart Challenge™ initiatives, the student ambassadors will use their personal connection to heart ...

Do no harm: Rethink treating diabetes, hypertension in frail older adults

2025-08-20
Effectively managing chronic conditions like diabetes and hypertension can greatly improve quality of life, reduce complications and extend longevity for older adults. However, when treatment becomes overly aggressive, it can do more harm than good. Every day, thousands of vulnerable older adults in the United States are harmed by intensive management of these conditions – resulting in dangerously low blood sugar or blood pressure, emergency visits, hospitalizations, disability or even death. These harms are ...

Hospitals, sanitation linked to spread of antibiotic resistance in Guatemala

2025-08-20
PULLMAN, Wash. — In Guatemalan communities, a recent visit to a health clinic or hospital — not antibiotic use — is the strongest predictor of carrying bacteria resistant to critical antibiotics, according to a new study led by Washington State University. Previous research in Guatemala’s Western Highlands found nearly 46% of residents were colonized in the gastrointestinal tract with bacteria known as extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE). These bacteria, often E. coli, can render the commonly used and important antibiotic ceftriaxone ineffective, complicating care for infections such as pneumonia or ...

Breaking new ground in stealth technology: KRISS develops core radar components domestically

2025-08-20
The Korea Research Institute of Standards and Science (KRISS, President Lee Ho Seong) has successfully localized core Radar Stealth technologies through indigenous development, without reliance on foreign technologies. This achievement is a significant milestone, laying the foundation for the establishment of stealth weapon systems in Korea, which have long been difficult to import due to their classification as national strategic military assets. As global military tensions rise and competition in advanced weapon development intensifies, the importance of developing stealth weapon systems has increased significantly. Radar stealth ...

Global Virus Network launches first-ever “Global Guardians” youth camp to prepare the next generation of virus hunters

2025-08-20
Tampa, FL, August 20, 2025 – The Global Virus Network (GVN), in partnership with the University of South Florida (USF) Youth Experiences and Hillsborough County Public Schools STEM Department, recently concluded its inaugural “Global Guardians: Youth for Pandemic Preparedness” summer camp, an immersive, hands-on experience that brought together some of Tampa’s brightest high school students with internationally renowned virologists, public health experts, and scientists. “This camp shows our students that science is a living, evolving field with real-world impact,” said Catherine ...

The quest for an HIV vaccine

2025-08-20
When SARS-CoV-2, the coronavirus that causes COVID-19, began spreading worldwide in 2020, many research teams immediately set to work developing a vaccine against it. Building on decades of previous work on mRNA technology and on other viral vaccines, including HIV, they achieved their goal within the year. The most widely used mRNA vaccine design contains the genetic instructions for the body to make the spike protein that the virus uses to enter cells. The resulting immune response protects against infection and, more importantly, disease and death. However, ...

Scientists discover a new crystal that breathes oxygen

2025-08-20
A team of scientists from Korea and Japan has discovered a new type of crystal that can "breathe"—releasing and absorbing oxygen repeatedly at relatively low temperatures. This unique ability could transform the way we develop clean energy technologies, including fuel cells, energy-saving windows, and smart thermal devices. The newly developed material is a special kind of metal oxide made of strontium, iron, and cobalt. What makes it extraordinary is that it can release oxygen when heated in a simple gas environment and then take it back in, all without falling apart. This process can be repeated many times, making it ideal for real-world applications. This ...

Robust isolated quantum spins established on a magnetic substrate

2025-08-20
Establishing robust isolated spins on solid surfaces is crucial for fabricating quantum bits or qubits, sensors, and single-atom catalysts. An isolated spin is a single spin that is shielded from external interactions. Because isolated spins can maintain their state for long periods, they are ideal for use as qubits, the basic units of quantum computation, and for ultrafast spintronic memory.  Consequently, significant research has been dedicated to identifying materials capable of producing a stable isolated quantum spin. Candidates include single atoms of transition metals such as copper (Cu) in the Cu-phthalocyanine molecule (CuPc), molecular magnets, nitrogen-vacancy ...

Omega-3’s could protect women against Alzheimer’s

2025-08-20
Omega fatty acids could protect against Alzheimer’s disease in women, new research has found. Analysis of lipids – fat molecules that perform many essential functions in the body – in the blood found there was a noticeable loss of unsaturated fats, such as those that contain omega fatty acids, in the blood of women with Alzheimer’s disease compared to healthy women. Scientists found no significant difference in the same lipid molecule composition in men with Alzheimer’s disease compared to healthy men, ...

LAST 30 PRESS RELEASES:

Calorie labelling linked to 2% average reduction in energy content of menu items

Widely prescribed opioid painkiller tramadol not that effective for easing chronic pain

Exercise snacks may boost cardiorespiratory fitness of physically inactive adults

15,000 women a year with breast cancer could benefit from whole genome sequencing, say researchers

Study highlights risks of Caesarean births to future pregnancies

GLP-1 agonists pose emerging challenge for PET-CT imaging, study finds

Scripps Research scientists unlock new patterns of protein behavior in cell membranes

Panama Canal may face frequent extreme water lows in coming decades

Flash Joule heating lights up lithium extraction from ores

COMBINEDBrain and MUSC announce partnership to establish biorepository for pediatric cerebrospinal fluid and CNS tissue bank

Questionable lead reporting for drinking water virtually vanished after Flint water crisis, study reveals

Assessing overconfidence among national security officials

Bridging two frontiers: Mitochondria & microbiota, Targeting Extracellular Vesicles 2025 to explore game-changing pathways in medicine

New imaging tech promises to help doctors better diagnose and treat skin cancers

Once dominant, US agricultural exports falter amid trade disputes and rising competition

Biochar from invasive weed shields rice from toxic nanoplastics and heavy metals

Rice University announces second cohort of Chevron Energy Graduate Fellows

Soil bacteria and minerals form a natural “battery” that breaks down antibiotics in the dark

Jamestown colonists brought donkeys, not just horses, to North America, old bones reveal

FIU cybersecurity researchers develop midflight defense against drone hijacking

Kennesaw State researcher aims to discover how ideas spread in the digital age

Next-generation perovskite solar cells are closer to commercial use

Sleep patterns linked to variation in health, cognition, lifestyle, and brain organization

University of Oklahoma researcher awarded funding to bridge gap between molecular data and tissue architecture

Nationally-recognized pathologist Paul N. Staats, MD, named Chair of Pathology at University of Maryland School of Medicine

The world’s snow leopards are very similar genetically. That doesn’t bode well for their future

Researchers find key to stopping deadly infection

Leafcutter ants have blind spots, just like truck drivers

Tayac receives funding for community engagement project

Parker receives funding for Elementary Education Program Professional Development School (PDS)

[Press-News.org] Integrated analysis of serum and fecal metabolites reveals the role of bile acid metabolism in drug-induced liver injury: Implications for diagnostic and prognostic biomarkers