GLP-1 receptor agonists and cancer risk in adults with obesity

JAMA Oncology

2025-08-21

(Press-News.org) About The Study: This retrospective cohort study found that taking glucagon-like peptide-1 receptor agonists (GLP-1RAs) was associated with a reduced overall risk of cancer, including lower risks of endometrial, ovarian, and meningioma cancers, among patients with obesity or overweight. However, taking GLP-1RAs may be associated with an increased risk of kidney cancer, highlighting the need for longer-term follow-up to clarify the underlying mechanisms and clinical implications of these findings.

Corresponding Author: To contact the corresponding author, Jiang Bian, PhD, email bianji@iu.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamaoncol.2025.2681)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaoncology/fullarticle/10.1001/jamaoncol.2025.2681?guestAccessKey=b6aa6c28-0f78-453c-820f-7bbccc2484b7&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=082125

END

ELSE PRESS RELEASES FROM THIS DATE:

Impact of a weight loss intervention on 1-year weight change in women with stage II/III breast cancer

2025-08-21

About The Study: In this secondary analysis of a randomized clinical trial, a telephone-based weight loss intervention induced significant weight loss in patients with breast cancer with overweight and obesity across demographic and treatment factors. Further follow-up of the Breast Cancer Weight Loss trial will evaluate whether the weight loss intervention improves disease outcomes. Corresponding Author: To contact the corresponding author, Jennifer A. Ligibel, MD, email jennifer_ligibel@dfci.harvard.edu. To access the embargoed ...

Novel tool helps identify key targets to strengthen CAR NK cell therapies

2025-08-21

Researchers developed the first genome-wide CRISPR screening tool for primary human natural killer (NK) cells Study revealed critical regulators of NK cell activity that can be targeted to improve chimeric antigen receptor (CAR) NK cell therapies Findings open new avenues for developing more effective CAR NK cell therapies for many cancers HOUSTON, AUGUST 21, 2025 ― Natural killer (NK) cells became markedly better at killing cancer cells after scientists removed key gene targets identified through a new genome-wide CRISPR screening tool, according to new research from The University of Texas MD Anderson ...

New RP-HPLC method for orlistat analysis validated

2025-08-21

A recent study published in Current Pharmaceutical Analysis introduces a robust and validated reverse-phase high-performance liquid chromatography (RP-HPLC) method for the analysis of orlistat, a widely used anti-obesity drug. The method, developed by researchers from KIET School of Pharmacy in India, ensures accurate quantification and is fully compliant with International Council for Harmonisation (ICH) guidelines. The research team, led by Kandasamy Nagarajan, optimized the chromatographic conditions to achieve high sensitivity and precision. "Our method uses an XBridge C8 column and acetonitrile as the mobile phase, providing sharp peaks ...

How AI will transform mental health support for patients with breast cancer

2025-08-21

From virtual counselors that can hear depression creeping into a person’s voice to smart watches that can detect stress, artificial intelligence is poised to revolutionize mental health care for patients with breast cancer. In a new paper, UVA Cancer Center’s J. Kim Penberthy, PhD, and colleagues detail the many ways artificial intelligence could help ensure patients receive the support they need. AI, they say, can identify patients at risk for mental-health struggles, get them treatment earlier, provide continuous psychological monitoring and even ...

First observations by the Total Anthropogenic and Natural emissions mapping SpectrOmeter-3 (TANSO-3) onboard the Global Observing SATellite for Greenhouse gases and Water cycle “IBUKI GW” (GOSAT-GW)

2025-08-21

1. Summary The National Institute for Environmental Studies (NIES), in cooperation with the Ministry of the Environment of Japan (MOE) and the Japan Aerospace Exploration Agency (JAXA), has been observing atmospheric carbon dioxide, methane, and other gases by utilizing the Greenhouse Gases Observing Satellite (GOSAT) Series, with the aim of advancing climate change science and contributing to the evaluation of climate change policies and initiatives. The Global Observing SATellite for Greenhouse gases and Water cycle “IBUKI GW” (GOSAT-GW)1, developed jointly by MOE, NIES, ...

Optimizing how cells self-organize

2025-08-21

Key Takeaways Harvard physicists have developed a computational method that can uncover the rules that cells use to self-organize, translating the complex process of cell growth into an optimization problem a computer can solve. The technique they use is automatic differentiation, originally built for training neural networks, but used in this context for predicting how small changes in genes or cellular signals affect the final design. Scientists could someday use such predictive models in real biological experiments to design living tissues with specific functions or shapes. One of the most fundamental processes in all of biology ...

Impact of cancer on forensic DNA methylation age estimation

2025-08-21

“[…]age estimation on blood stains from cancer patients might not result in significantly higher estimation errors, except for very aggressive forms of cancer.” BUFFALO, NY — August 21, 2025 — A new research paper was published in Volume 17, Issue 7 of Aging (Aging-US) on July 17, 2025, titled “The influence of cancer on a forensic age estimation tool.” In this study by Charlotte Sutter, Daniel Helbling, Cordula Haas and Jacqueline Neubauer from the Zurich Institute of Forensic Medicine, University ...

Researchers use photonic origami to fold glass into microscopic 3D optical devices

2025-08-21

WASHINGTON — Researchers have developed a technique to fold glass sheets into microscopic 3D photonic structures directly on a chip — a process they call photonic origami. The method could enable tiny, yet complex optical devices for data processing sensing and experimental physics. “Existing 3D printers produce rough 3D structures that aren’t optically uniform and thus can’t be used for high-performance optics,” said research team leader Tal Carmon from Tel Aviv University in Israel. “Mimicking the way a pinecone’s scales bend outward to release ...

Dr. Matthew Greenblatt awarded Paul-Gallin Trailblazer Prize for bone stem cell discoveries

2025-08-21

Dr. Matthew Greenblatt will receive the prestigious Paul-Gallin Trailblazer Prize for Physician-Scientists in recognition of his discovery of distinct types of bone-building stem cells in different parts of the body. These unique cells have the ability to create copies of themselves as well as develop into specialized cells that perform distinct functions in the body. Each year, the Foundation for the National Institutes of Health awards the Paul-Gallin Trailblazer Prize to an early- to mid-career physician-scientist who is translating their basic science discoveries into new ways to diagnose, prevent, treat, or cure disease ...

Natural products used as disinfectants in prosthodontics and oral implantology

2025-08-21

Infection control is paramount in prosthodontics and oral implantology to prevent complications like denture stomatitis and peri-implantitis. While synthetic disinfectants (e.g., chlorhexidine) are widely used, their side effects—including mucosal irritation, toxicity, and antimicrobial resistance—drive the search for safer alternatives. Natural products derived from plants, animals, and minerals offer promising solutions due to their antimicrobial efficacy, biocompatibility, and environmental sustainability. Key Natural Agents and Mechanisms Plant-Based Products: Clove oil (eugenol), tea tree oil (terpinen-4-ol), neem (azadirachtin), ...

GLP-1 receptor agonists and cancer risk in adults with obesity

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: