CRF announces TCT 2025 late-breaking clinical trials and science

Annual scientific symposium will take place October 25-28 in San Francisco

2025-08-27

(Press-News.org) NEW YORK – August 27, 2025 – The Cardiovascular Research Foundation® (CRF®) is excited to announce the late-breaking clinical trials and science set to be presented at TCT® 2025, the annual scientific symposium of CRF® and the world’s premier educational meeting specializing in interventional cardiovascular medicine. This year’s conference will take place October 25–28 at the Moscone Center in San Francisco, bringing together top experts, innovators, and clinicians from around the globe.

For more than 30 years, TCT® has served as a cornerstone for advancing cardiovascular care, showcasing transformative research and fostering collaboration across disciplines. Each year, the symposium delivers pivotal data that shapes clinical practice and enhances outcomes for patients with heart and vascular disease.

Late-breaking clinical trials and science are among the most anticipated sessions, offering first looks at novel therapies, devices, and techniques. This year, 28 cutting-edge studies will be presented, focusing on the safety and efficacy of minimally invasive procedures, emerging pharmaceuticals, and breakthrough technologies aimed at preventing and treating cardiovascular conditions.

These high-impact findings will be featured in the main program and spotlighted during dedicated press briefings on Sunday, October 26, Monday, October 27, and Tuesday, October 28.

Sunday, October 26, 2025

One-Year Results of the SELUTION DeNovo Trial Comparing a Strategy of PCI with a Sirolimus-eluting Balloon and Provisional Stenting Versus Systematic DES Implantation to Treat DeNovo Coronary Lesions

Christian M. Spaulding

Sirolimus-Eluting Balloon Versus Repeat Drug-Eluting Stenting or Balloon Angioplasty for In-stent Restenosis

Donald Cutlip

Randomized Comparison of Intravascular Lithotripsy vs. Cutting Balloon Treatment in Calcified Coronary Artery Disease – The Short-CUT Trial

Suzanne J. Baron

A Randomized, Multicenter, Non-Inferiority Comparison of Intravascular Lithotripsy and Super-High-Pressure Non-Compliant Balloons for Treatment of Calcified and Refractory Coronary Lesions - The VICTORY Trial

Randomized Controlled Trial of Mechanical Thrombectomy with Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Results from STORM-PE

Robert A. Lookstein

Three-Year Outcomes of the LIFE-BTK Randomized Controlled Trial Evaluating the Esprit™ BTK Drug-Eluting Resorbable Scaffold for Treatment of Infrapopliteal Lesions

Sahil A. Parikh

Short-Term Anticoagulation Versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure

Josep Rodés-Cabau

Evaluating Real-World Outcomes of the EVOQUE Valve in Early Commercial Experience from the STS/ACC TVT Registry

Raj Makkar

Lessons Learned from 800+ Patients Treated with Tricuspid TEER: Update from the TRILUMINATE Pivotal Trial

Jonathan G. Schwartz

Monday, October 27, 2025

Defining the Prevalence of Valvular Heart Disease in Older Americans: The PREVUE-VALVE Study

David J. Cohen

Long-Term Follow-up of the PARTNER 3 Low-Risk Randomized Trial: Seven-Year Clinical and Echocardiographic Outcomes

Michael J. Mack

Tendyne Transcatheter Mitral Valve System in Patients with Severe Mitral Annular Calcification: One-year Outcomes from the SUMMIT Severe MAC Cohort

Paul Sorajja

Percutaneous Transseptal Transcatheter Mitral Valve Replacement using a Dedicated Balloon Expandable Valve: 1 Year Outcomes from the ENCIRCLE Trial using the SAPIEN M3

David Daniels

Long Term Clinical Outcomes in Patients Treated with the Bioadaptor Compared with a Contemporary Drug Eluting Stent: The INFINITY-SWEDEHEART Randomized Trial

David Erlinge

Comparison of Drug-Coated Versus Conventional Balloons for Treatment of Side Branches of Bifurcation Lesions: The OCVC-BIF Study

Takayuki Ishihara

Sirolimus-Eluting Iron Bioresorbable Scaffold in Coronary Artery Disease: Two-Year Results of IRONMAN-II Randomized Controlled Trial

Lei Song

Drug-Coated Balloon Angioplasty with Rescue Stenting Versus Intended Stenting for the Treatment of DeNovo Coronary Artery Lesions: 3-Year Clinical Outcomes of the REC-CAGEFREE I Trial

Chao Gao

Percutaneous Coronary Angioplasty Versus Coronary Artery Bypass Grafting in the Treatment of Unprotected Left Main Stenosis: 10-year Mortality Outcomes from the Randomized NOBLE Trial

Evald H. Christiansen

Tuesday, October 28, 2025

Percutaneous Coronary Intervention of Native Coronary Artery versus Saphenous Vein Graft in Patients with Prior Coronary Artery Bypass Graft Surgery (PROCTOR): A Multicenter, Open-label, Randomized Trial

Ruben de Winter

Effects of Intracoronary Low-Dose Recombinant Tissue Plasminogen Activator as an Ajunct to Primary PCI in Patients with STEMI and Large Thrombus Burden: A Randomized, Double-Blind, Placebo-Controlled Trial

Shamir R. Mehta

Immediate Instantaneous Wave-Free Ratio Guided Versus Deferred Cardiac Magnetic Resonance Imaging Guided Revascularization of Non-Culprit Lesions in Patients with Acute ST-Elevation Myocardial Infarction: A Randomized Superiority Trial

Robin Nijveldt

Stratified Treatment of Myocardial Infarction with Non-Obstructive Coronary Arteries: The PROMISE Trial

Rocco Antonio Montone

Supraflex Cruz versus Xience in Patients with Diabetes and Multivessel Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: Results from the TUXEDO-2 Randomized Trial

Upendra Kaul

iFR Versus Angiography-Guided CABG: 3-Year Results of the iCABG Randomized Trial

Rasa Ordiene

Randomized Comparison of the Supraflex CruzTM vs. SYNERGYTM Drug-Eluting Stents: The Multivessel TALENT Randomized Trial

Patrick W. Serruys

A Prospective, Randomized Clinical Trial of Hemodynamic Support with a Novel Developed pVAD Versus IABP in Patients Undergoing High-Risk Percutaneous Coronary Intervention

Rui Wang

AI-Enabled ECG Interpretation in STEMI: Findings from a Multicenter U.S. Registry

Timothy D. Henry

The Effectiveness and Safety of a Planned Investment Procedure in High-Risk Chronic Total Occlusions - The INVEST CTO Single Arm Study

Anja Oksnes

Media are invited to attend TCT® and can apply for media credentials at: https://www.tctconference.com/press-registration.

Receive updates on X at https://x.com/TCTConference and https://x.com/crfheart.

About CRF® and TCT®

The Cardiovascular Research Foundation® (CRF®) is a global leader in interventional cardiovascular medicine, driving innovation, spearheading groundbreaking research, and transforming education in the field. Through its relentless pursuit of excellence, CRF® not only accelerates medical breakthroughs but also equips healthcare professionals with the tools and knowledge necessary to enhance survival rates and elevate the quality of life for millions worldwide. CRF®’s centers of excellence include the CRF® Skirball Center for Innovation, CRF® Clinical Trials Center, CRF® Center for Education, CRF® Digital, TCTMD®, and Structural Heart: The Journal of the Heart Team.

Transcatheter Cardiovascular Therapeutics® (TCT®) is the annual scientific symposium of CRF® and the world’s premier educational meeting specializing in interventional cardiovascular medicine. Anchored in a legacy spanning over three decades, TCT® is a world-class educational experience featuring disruptive innovation, scientific breakthroughs, expert-led tutorials, hands-on training, and ample opportunities for networking and collaboration.

For more information, visit www.crf.org and www.tctconference.com.

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CRF announces TCT 2025 late-breaking clinical trials and science

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