Risk of myocarditis or pericarditis with high-dose vs standard-dose influenza vaccine

JAMA Network Open

2025-08-30

(Press-News.org) About The Study: In this prespecified analysis of the DANFLU-2 trial, the risk of incident myocarditis or pericarditis was lower among individuals randomized to high-dose inactivated influenza vaccine vs standard-dose- inactivated influenza vaccine. Despite sporadic reports of myocarditis and pericarditis associated with influenza vaccination, the consistency of our results with vs without inclusion of events occurring immediately after vaccination negates a dose-response association and a causal link.

Corresponding Author: To contact the corresponding author, Tor Biering-Sørensen, MD, MSc, MPH, PhD, email tor.biering@gmail.com.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2025.36889?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=083025

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Risk of myocarditis or pericarditis with high-dose vs standard-dose influenza vaccine

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