(Press-News.org) About The Study: In this individual participant data meta-analysis of 4 randomized clinical trials (RCTs), and an overall meta-analysis of 8 RCTs of patients with severe symptomatic aortic stenosis at low to intermediate risk, transcatheter aortic valve implantation (TAVI) was associated with a reduction in the 1-year incidence of all-cause death or any stroke. These findings emphasize TAVI as alternative option in patients at low to intermediate risk. Long-term follow-up is warranted to evaluate sustainability of these findings.
Corresponding Authors: To contact the corresponding authors, email Moritz Seiffert, MD, (moritz.seiffert@bergmannsheil.de) and Andreas Ziegler, PhD, (andreas.ziegler@cardio-care.ch).
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2025.3403?guestAccessKey=6f1c3c46-c58f-4fd4-a450-f7b2ec3aabdd&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=083025
END
Transcatheter or surgical treatment of patients with aortic stenosis at low to intermediate risk
JAMA Cardiology
2025-08-30
ELSE PRESS RELEASES FROM THIS DATE:
Promising new drug for people with stubborn high blood pressure
2025-08-30
A new treatment has been shown to significantly lower blood pressure in people whose levels stay dangerously high, despite taking several existing medicines, according to the results of a Phase III clinical trial led by a UCL Professor.
Globally around 1.3 billion people have high blood pressure (hypertension), and in around half of cases the condition is uncontrolled or treatment resistant. These individuals face a much greater risk of heart attack, stroke, kidney disease, and early death. In the UK the number of people with hypertension is around 14 ...
One shot of RSV vaccine effective against hospitalization in older adults for two seasons
2025-08-30
One shot of an RSV vaccine protects adults ages 60 or older from RSV-associated hospitalization and critical illness during two consecutive RSV seasons, according to a study published in JAMA today by the IVY Network research group.
RSV causes substantial seasonal illness during fall and winter in the U.S., with an estimated 100,000-150,000 hospitalizations and 4,000-8,000 deaths occurring annually among adults 60 or older.
The results reinforce the recommendations for RSV vaccines in older adults and lay the groundwork for understanding how long a single dose of the vaccine may be effective, ...
Bivalent RSV prefusion F protein–based vaccine for preventing cardiovascular hospitalizations in older adults
2025-08-30
About The Study: In adults age 60 or older, all-cause cardiorespiratory hospitalization was significantly lower with respiratory syncytial virus (RSV) prefusion F protein than with no vaccine. The findings suggest potential downstream cardiorespiratory benefits of RSV immunization, although the effect on all-cause cardiovascular hospitalization was not statistically significant.
Corresponding Author: To contact the corresponding author, Tor Biering-Sørensen, MD, MSc, MPH, PhD, email tor.biering@gmail.com.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
Editor’s ...
Clonal hematopoiesis and risk of new-onset myocarditis and pericarditis
2025-08-30
About The Study: In this study, clonal hematopoiesis of indeterminate potential (CHIP) was a strong risk factor for myocarditis and pericarditis among middle-aged adults. Targeting CHIP and its downstream pathways may represent a strategy for preventing or treating pericarditis and myocarditis.
Corresponding Author: To contact the corresponding author, Michael C. Honigberg, MD, MPP, email mhonigberg@mgh.harvard.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
Editor’s Note: Please see the article for additional information, including other authors, author contributions ...
Risk of myocarditis or pericarditis with high-dose vs standard-dose influenza vaccine
2025-08-30
About The Study: In this prespecified analysis of the DANFLU-2 trial, the risk of incident myocarditis or pericarditis was lower among individuals randomized to high-dose inactivated influenza vaccine vs standard-dose- inactivated influenza vaccine. Despite sporadic reports of myocarditis and pericarditis associated with influenza vaccination, the consistency of our results with vs without inclusion of events occurring immediately after vaccination negates a dose-response association and a causal link.
Corresponding Author: To ...
High-dose vs standard-dose influenza vaccine and cardiovascular outcomes in older adults
2025-08-30
About The Study: This study found reduced incidence of cardiorespiratory hospitalization among those who received high-dose inactivated influenza vaccine vs standard-dose inactivated influenza vaccine, driven by a lower incidence of cardiovascular hospitalizations, and particularly heart failure hospitalizations. These differences should be interpreted as exploratory findings in the setting of a large randomized clinical trial with a neutral primary outcome.
Corresponding Author: To contact the corresponding author, Tor Biering-Sørensen, ...
Prevalence, determinants, and time trends of cardiovascular health in the WHO African region
2025-08-30
About The Study: This situational analysis of cross-sectional WHO STEPS surveys of cardiovascular health (CVH) status region identified actionable factors of the CVH status across 22 countries in the WHO African Region. This information is crucial for guiding policy efforts in cardiovascular disease prevention in countries of the WHO African Region.
Corresponding Author: To contact the corresponding author, Jean-Philippe Empana, MD, PhD, email jean-philippe.empana@inserm.fr.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
Editor’s Note: Please see the article for additional information, including ...
New study finds that, after a heart attack, women have worse prognosis when treated with beta-blockers
2025-08-30
A major new analysis from REBOOT (Treatment with Beta-blockers after Myocardial Infarction without Reduced Ejection Fraction) clinical trial, an international study coordinated by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), published at the European Heart Journal has revealed important sex-specific differences in the effects of beta-blockers following heart attacks, raising questions about long-standing treatment practices.
REBOOT, presented in a Hotline session of the ESC congress in Madrid, ...
CNIC-led REBOOT clinical trial challenges 40-year-old standard of care for heart attack patients
2025-08-30
Madrid, August 30, 2025. An international clinical trial coordinated by the Centro Nacional de Investigaciones Cardiovasculares (CNIC), in collaboration with the Mario Negri Institute for Pharmacological Research in Milan, has found that beta-blockers—drugs commonly prescribed for a range of cardiac conditions—offer no clinical benefit for patients who have had an uncomplicated myocardial infarction (i.e., without deterioration of the heart function after the event).
The findings—published in two articles in The New England Journal of Medicine and The Lancet and presented today during a “Hot Line” ...
Systolic blood pressure and microaxial flow pump–associated survival in infarct-related cardiogenic shock
2025-08-30
About The Study: Randomization systolic blood pressure (SBP) was associated with the survival benefit of microaxial flow pump treatment, with the most hypotensive patients deriving the largest survival benefit. Early SBP may help identify patients most likely to gain a net benefit from microaxial flow pump treatment. Findings are hypothesis generating.
Corresponding Author: To contact the corresponding author, Astrid Duus Mikkelsen, MD, email astrid.duus.mikkelsen@reigonh.dk.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
Editor’s Note: Please see the article for additional information, including ...
LAST 30 PRESS RELEASES:
Red light therapy shows promise for protecting football players’ brains
Trees — not grass and other greenery — associated with lower heart disease risk in cities
Chemical Insights scientist receives Achievement Award from the Society of Toxicology
Breakthrough organic crystalline material repairs itself in extreme cold temperatures, unlocking new possibilities for space and deep-sea technologies
Scientists discover novel immune ‘traffic controller’ hijacked by virus
When tropical oceans were oxygen oases
Positive interactions dominate among marine microbes, six-year study reveals
Safeguarding the Winter Olympics-Paralympics against climate change
Most would recommend RSV immunizations for older and pregnant people
Donated blood has a shelf life. A new test tracks how it's aging
Stroke during pregnancy, postpartum associated with more illness, job status later
American Meteorological Society announces new executive director
People with “binge-watching addiction” are more likely to be lonely
Wild potato follows a path to domestication in the American Southwest
General climate advocacy ad campaign received more public engagement compared to more-tailored ad campaign promoting sustainable fashion
Medical LLMs may show real-world potential in identifying individuals with major depressive disorder using WhatsApp voice note recordings
Early translational study supports the role of high-dose inhaled nitric oxide as a potential antimicrobial therapy
AI can predict preemies’ path, Stanford Medicine-led study shows
A wild potato that changed the story of agriculture in the American Southwest
Cancer’s super-enhancers may set the map for DNA breaks and repair: A key clue to why tumors become aggressive and genetically unstable
Prehistoric tool made from elephant bone is the oldest discovered in Europe
Mineralized dental plaque from the Iron Age provides insight into the diet of the Scythians
Salty facts: takeaways have more salt than labels claim
When scientists build nanoscale architecture to solve textile and pharmaceutical industry challenges
Massive cloud with metallic winds discovered orbiting mystery object
Old diseases return as settlement pushes into the Amazon rainforest
Takeaways are used to reward and console – study
Velocity gradients key to explaining large-scale magnetic field structure
Bird retinas function without oxygen – solving a centuries-old biological mystery
Pregnancy- and abortion-related mortality in the US, 2018-2021
[Press-News.org] Transcatheter or surgical treatment of patients with aortic stenosis at low to intermediate riskJAMA Cardiology