Ambient air pollution and the severity of Alzheimer disease neuropathology

JAMA Neurology

2025-09-08

(Press-News.org) About The Study: In this study, fine particulate matter air pollution exposure was associated with increased dementia severity and increased Alzheimer disease neuropathologic change. Population-based studies are needed to better understand this relationship.

Corresponding Author: To contact the corresponding author, Edward B. Lee, MD, PhD, email edward.lee@pennmedicine.upenn.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamaneurol.2025.3316)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2025.3316?guestAccessKey=55b8956b-ab3e-4a8e-a029-d503e36f33ed&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=090825

END

ELSE PRESS RELEASES FROM THIS DATE:

Ocean warming puts vital marine microbe Prochlorococcus at risk

2025-09-08

Among the tiniest living things in the ocean are a group of single celled microbes called Prochlorococcus. They are cyanobacteria, also known as blue-green algae, and they supply nutrients for animals all the way up the food chain. Over 75% of surface waters teem with Prochlorococcus, but as ocean temperatures rise, researchers fear that the water might be getting too warm to support the population. Prochlorococcus is the most abundant photosynthesizing organism in the ocean, accounting for 5% of global photosynthesis. Because Prochlorococcus thrive in the tropics, researchers predicted that they would adapt ...

Nicotine pouches may offer path to reduced tobacco harm, Rutgers study finds

2025-09-08

As lawmakers and public health experts debate the safety of nicotine pouches, researchers from Rutgers Health found that for now, most adults that use these products also have a history of tobacco use and may be choosing these products as a possible step toward reducing or quitting more dangerous forms of nicotine delivery. The findings – believed to be the first national estimates of daily nicotine pouch use in the U.S. – were published in JAMA Network Open. Faced with declining cigarette sales, tobacco manufacturers in the U.S. are turning to tobacco-free nicotine ...

Duke-NUS study reveals how dengue rewires the immune system, reshaping vaccine response

2025-09-08

SINGAPORE, 8 SEPTEMBER 2025—Just as a computer’s operating system can be rewritten after a major update, dengue infection can ‘re-programme’ the body’s immune system, leaving a long-lasting genetic imprint that influences how people respond to future infections—an effect not seen with vaccination. These novel insights from a recent study shed light on the mechanics of dengue disease progression and vaccine action, filling an important knowledge gap on how even imperfect vaccines can be used safely. It also paves the way for the future development of safer and ...

Dr. Gianluca Ianiro wins a prestigious grant from the European Research Council (ERC)

2025-09-08

The MicroRestore project, presented by Dr. Gianluca Ianiro, has been awarded one of the European Research Council (ERC) Starting Grants, intended for talented young scientists who have completed their doctoral studies (PhD) no more than seven years ago. Following a rigorous selection process and an in-person interview, an international panel of experts draws up a merit ranking that rewards scientific excellence. The ERC Starting Grant—worth €1.5 million and lasting five years—is a highly prestigious recognition, that had never before been awarded to a researcher from the Fondazione Policlinico Gemelli/Università ...

‘Rogue’ DNA rings reveal earliest clues to deadly brain cancer’s growth

2025-09-08

‘Rogue’ DNA Rings Reveal Earliest Clues to Deadly Brain Cancer’s Growth An international team of scientists has revealed how rogue rings of DNA that float outside of our chromosomes – known as extrachromosomal DNA, or ecDNA – can drive the growth of a large proportion of glioblastomas, the most common and aggressive adult brain cancer. The discovery could open the door to much-needed new approaches to diagnose glioblastoma early, track its progress and treat it more effectively. The findings, published today in Cancer Discovery, are the first to suggest that ecDNA ...

Clinical study deepens understanding of mesothelioma and opens the door to potential treatment options

2025-09-08

WASHINGTON – People with operable diffuse pleural mesothelioma may benefit from immunotherapy before and after surgery, based on results of a clinical trial exploring the sequence of treatment and the role of surgery for this difficult to treat cancer. Mesothelioma is a rare cancer that affects the tissue that lines many organs of the body. Approximately 30,000 cases are diagnosed every year worldwide, most of them in the pleura, or lining of the lungs. It occurs most often in people who have been exposed ...

New study and major data updates expand the Kids First data ecosystem

2025-09-08

The Gabriella Miller Kids First Pediatric Research Program (Kids First) has released its 36th study and introduced significant new data updates to two existing studies, further advancing efforts to uncover the genetic foundations of childhood cancers and congenital conditions. This brings the total data files available at the Kids First Data Resource Center (Kids First DRC) to more than 110,000. WHO: Kids First, a program from the National Institutes of Health (NIH) WHAT: Announcing the latest data releases to the Kids First data ecosystem. Newly released and updated datasets are available publicly, including: CONGENITAL CONDITIONS Kids ...

Seaweed snare: Sargassum stops sea turtle hatchlings in their tracks

2025-09-08

Every year, sea turtles hatch on Florida’s beaches and make their way from the sand to the ocean – a critical journey that determines their chances of survival. As these hatchlings navigate obstacles such as artificial lights, beach debris and predators like birds and crabs, a new hazard looms. Sargassum seaweed washing up on Florida’s shores in record amounts is more than just a nuisance for beachgoers – it’s becoming a serious threat to vulnerable sea turtle hatchlings. While it’s long been known that obstacles on the beach can slow down hatchlings and put ...

Scientists uncover key to decoupling economic growth from pollution in developing countries

2025-09-08

Balancing environmental conservation with economic progress is one of the most pressing challenges of our time. This is particularly difficult for many developing countries, which urgently need to lift their populations out of poverty while grappling with the increasing degradation of their environment. Unfortunately, a common belief is that these nations have to choose between economic growth and a clean environment—a situation made more complex by their reliance on foreign aid. While the United Nations Sustainable Development Goals provide a global roadmap for tackling such issues, ...

Frailty fuels gut imbalance and post-surgery gastrointestinal risks

2025-09-08

Gastrointestinal (GI) complications, such as postoperative ileus (POI) and intra-abdominal infections (IAI), remain a major concern after radical cystectomy for bladder cancer. Even with advances in surgical techniques, including robot-assisted radical cystectomy with intracorporeal urinary diversion (iRARC), and the adoption of enhanced recovery protocols, these complications continue to affect a substantial proportion of patients. They not only prolong hospital stays but also increase patient morbidity, underscoring the need to identify risk factors beyond surgical technique alone. In a new study ...

Ambient air pollution and the severity of Alzheimer disease neuropathology

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: