Childhood loneliness and cognitive decline and dementia risk in middle-aged and older adults

JAMA Network Open

2025-09-12

(Press-News.org) About The Study: In this cohort study, childhood loneliness was associated with cognitive decline and dementia risk in middle and later adulthood, even in the absence of adult loneliness. Early interventions aimed at reducing childhood loneliness may help promote lifelong cognitive health and reducing dementia risk.

Corresponding Author: To contact the corresponding author, Xiuhua Guo, PhD, email statguo@ccmu.edu.cn.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2025.31493)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

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Childhood loneliness and cognitive decline and dementia risk in middle-aged and older adults

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