PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Researchers build 'artificial ovary' to develop oocytes into mature human eggs

2010-09-14
(Press-News.org) PROVIDENCE, R.I. [Brown University] — Researchers at Brown University and Women & Infants Hospital have invented the first artificial human ovary, an advance that provides a potentially powerful new means for conducting fertility research and could also yield infertility treatments for cancer patients. The team has already used the lab-grown organ to mature human eggs.

"An ovary is composed of three main cell types, and this is the first time that anyone has created a 3-D tissue structure with triple cell line," said Sandra Carson, professor of obstetrics and gynecology at the Warren Alpert Medical School of Brown University and director of the Division of Reproductive Endocrinology and Infertility at Women & Infants Hospital. Carson is a senior author of a recent article in the Journal of Assisted Reproduction and Genetics that describes the innovation.

Carson said that the ovary not only provides a living laboratory for investigating fundamental questions about how healthy ovaries work, but also can act as a testbed for seeing how problems, such as exposure to toxins or other chemicals, can disrupt egg maturation and health.

Clinically, the artificial ovary could play a role in preserving the fertility of women facing cancer treatment in the future, said Stephan Krotz, a Houston fertility doctor who is the paper's lead author and a former fellow in Carson's lab. Immature eggs could be salvaged and frozen before the onset of chemotherapy or radiation, he said, and then matured outside the patient in the artificial ovary.

Building an ovary

What makes the artificial ovary a functional tissue, rather than just a cell culture, is that it brings all three ovarian cell types into a 3-D arrangement similar to a real ovary in the body. The means for making such compositions of cells was invented in the lab of Jeffrey Morgan, associate professor of medical science and engineering, who is a co-author of the paper published online Aug. 25. His so-called 3D Petri dishes are made of a moldable agarose gel that provides a nurturing template to encourage cells to assemble into specific shapes.

To create the ovary, the researchers formed honeycombs of theca cells, one of two key types in the ovary, donated by reproductive-age (25-46) patients at the hospital. After the theca cells grew into the honeycomb shape, spherical clumps of donated granulosa cells were inserted into the holes of the honeycomb together with human egg cells, known as oocytes. In a couple days the theca cells enveloped the granulosa and eggs, mimicking a real ovary.

The big test, however, was whether the structure could function like an ovary — namely to mature eggs. In experiments the structure was able to nurture eggs from the "early antral follicle" stage to full maturity.

"[This] represents the first success in using 3-D tissue engineering principles for in vitro oocyte maturation," the researchers wrote in the journal article.

Carson said her goal was never to invent an artificial organ, per se, but merely to create a research environment in which she could study how theca and granulosa cells and oocytes interact. When she learned of Morgan's 3-D Petri dishes, they began to collaborate on creating an organ. Morgan said this is the first fully functional tissue to be made using the method.

To help fund the work, Morgan and Carson applied for and won a Collaborative Research Award from the Rhode Island Science and Technology Advisory Council (STAC). STAC grants encourage research with commercial potential. Morgan has recently founded a local Rhode Island startup, MicroTissues Inc. The company will begin selling these micro-mold tools in about a month to researchers looking to engineer 3-D tissues. Other funding came from Women & Infants Hospital.

With what appears to be a fully functional artificial organ, Carson and Morgan continue to collaborate and are now embarking on the studies she dreamed it would make possible. She's reluctant to predict what they'll turn up, however.

"This is really very, very new," she said.

INFORMATION: The paper's other authors are Jared Robins, Toni-Marie Ferruccio, Richard Moore and Margaret Steinhoff, all of Brown University.

Editors: Brown University has a fiber link television studio available for domestic and international live and taped interviews, and maintains an ISDN line for radio interviews. For more information, call (401) 863-2476.


ELSE PRESS RELEASES FROM THIS DATE:

VCU study: Team uncovers possible risk gene for schizophrenia

2010-09-14
RICHMOND, Va. (Sept. 14, 2010) – An international team of researchers has identified a risk gene for schizophrenia, including a potentially causative mutation, using genome-wide association data-mining techniques and independent replications. The results of the research, led by Xiangning Chen, Ph.D., associate professor of psychiatry and human and molecular genetics in Virginia Commonwealth University's School of Medicine and the Virginia Institute for Psychiatric and Behavioral Genetics, and Kenneth S. Kendler, M.D., professor of psychiatry and human and molecular genetics ...

Long-term stenting of aortic coarctation yields 77 percent success rate

2010-09-14
Researchers from the Congenital Cardiovascular Interventional Study Consortium (CCISC) who evaluated the intermediate and long-term results of stent implantation for aortic coarctation found that cumulative intermediate success was 86%, and cumulative long-term success was 77%. Results of this study appear in the October issue of Catheterization and Cardiovascular Interventions, a journal published by Wiley-Blackwell on behalf of The Society for Cardiovascular Angiography and Interventions. Coarctation, or narrowing, of the aorta, restricts blood flow to the lower extremities ...

Chandra finds evidence for stellar cannibalism

Chandra finds evidence for stellar cannibalism
2010-09-14
Evidence that a star has recently engulfed a companion star or a giant planet has been found using NASA's Chandra X-ray Observatory. The likely existence of such a "cannibal" star provides new insight into how stars and the planets around them may interact as they age. The star in question, known as BP Piscium (BP Psc), appears to be a more evolved version of our Sun, but with a dusty and gaseous disk surrounding it. A pair of jets several light years long blasting out of the system in opposite directions has also been seen in optical data. While the disk and jets ...

Molecule identified that increases survival of stomach cancer patients

2010-09-14
"The high presence of microRNA 451 enhances the response to treatment with chemo-radiotherapy and increases the survival of patients with stomach cancer", explained Dr. Jesús García-Foncillas, chief researcher of the Pharmacogenomics Laboratory at the Applied Medical Research Centre (CIMA) and Director of Oncology at the University Hospital of Navarra. This was one of the results presented at the IV Congress of the Spanish Society for Pharmacogenetics and Pharmacogenomic, recently held at CIMA. Pharmacogenetics studies the genetic bases determining the response of an ...

New current meter provides answers for lobster industry, oyster farmers, scientists

2010-09-14
NARRAGANSETT, R.I. – September 14, 2010 – When a federal fisheries scientist sought to learn how ocean currents affect the catch rate of lobsters, he turned to a University of Rhode Island oceanographer who had developed an innovative and inexpensive meter for measuring currents near the bottom of bays, rivers and other shallow waters. So did aquaculture farmers in Rhode Island looking to identify the best site for farming oysters, Cape Cod officials interested in understanding tidal fluctuations in Waquoit Bay, and students at Cohasset (Mass.) High School studying circulation ...

Why 'scientific consensus' fails to persuade

2010-09-14
Suppose a close friend who is trying to figure out the facts about climate change asks whether you think a scientist who has written a book on the topic is a knowledgeable and trustworthy expert. You see from the dust jacket that the author received a Ph.D. in a pertinent field from a major university, is on the faculty at another one, and is a member of the National Academy of Sciences. Would you advise your friend that the scientist seems like an "expert"? If you are like most people, the answer is likely to be, "it depends." What it depends on, a recent study found, ...

New American Chemical Society podcast: Big building blocks from nanoparticles

New American Chemical Society podcast:  Big building blocks from nanoparticles
2010-09-14
WASHINGTON, Sept. 14, 2010 — A new genre of construction materials, made with particles barely 1/50,000th the width of a human hair, is about to play a big role in the building of homes, offices, bridges, and other structures, according to the latest episode in the American Chemical Society's (ACS) award-winning podcast series, "Global Challenges/Chemistry Solutions." A new Global Challenges podcast and website is highlighting both the potential benefits of these nanomaterials in improving construction materials and the need for guidelines to regulate their use and ...

First US trial of bone-marrow stem cells for heart attack patients proves safe

2010-09-14
The first randomized, placebo-controlled U.S. clinical trial to assess the use of bone marrow-derived mononuclear cells (BMC) in patients after a ST-elevation myocardial infarction (STEMI; severe heart attack) demonstrated a strong safety profile for this cell therapy, based on phase 1 results published in the September issue of the American Heart Journal. "The use of adult stem cells, derived from the patient's own bone marrow, presents a potential new type of therapy to benefit individuals after they suffer a heart attack," says the study's principal investigator Jay ...

Women more likely than men to accept global warming

Women more likely than men to accept global warming
2010-09-14
EAST LANSING, Mich. — Women tend to believe the scientific consensus on global warming more than men, according to a study by a Michigan State University researcher. The findings, published in the September issue of the journal Population and Environment, challenge common perceptions that men are more scientifically literate, said sociologist Aaron M. McCright. "Men still claim they have a better understanding of global warming than women, even though women's beliefs align much more closely with the scientific consensus," said McCright, an associate professor with ...

Watercress may 'turn off' breast cancer signal

2010-09-14
The research, unveiled at a press conference today (14 September 2010), shows that the watercress compound is able to interfere with the function of a protein which plays a critical role in cancer development. As tumours develop they rapidly outgrow their existing blood supply so they send out signals which make surrounding normal tissues grow new blood vessels into the tumour which feed them oxygen and nutrients. The research, led by Professor Graham Packham of the University of Southampton, shows that the plant compound (called phenylethyl isothiocyanate) found ...

LAST 30 PRESS RELEASES:

Community partners key to success of vaccine clinic focused on neurodevelopmental conditions

Low-carbon collaborative dual-layer optimization for energy station considering joint electricity and heat demand response

McMaster University researchers uncover potential treatment for rare genetic disorders

The return of protectionism: The impact of the Sino-US trade war

UTokyo and NARO develop new vertical seed distribution trait for soybean breeding

Research into UK’s use of plastic packaging finds households ‘wishcycle’ rather than recycle – risking vast contamination

Vaccine shows promise against aggressive breast cancer

Adverse events affect over 1 in 3 surgery patients, US study finds

Outsourcing adult social care has contributed to England’s care crisis, argue experts

The Lancet: Over 800 million adults living with diabetes, more than half not receiving treatment, global study suggests

New therapeutic approach for severe COVID-19: faster recovery and reduction in mortality

Plugged wells and reduced injection lower induced earthquake rates in Oklahoma

Yin selected as a 2024 American Society of Agronomy Fellow

Long Covid could cost the economy billions every year

Bluetooth technology unlocks urban animal secrets

This nifty AI tool helps neurosurgeons find sneaky cancer cells

Treatment advances, predictive biomarkers stand to improve bladder cancer care

NYC's ride-hailing fee failed to ease Manhattan traffic, new NYU Tandon study reveals

Meteorite contains evidence of liquid water on Mars 742 million years ago

Self-reported screening helped reduce distressing symptoms for pediatric patients with cancer

Which risk factors are linked to having a severe stroke?

Opening borders for workers: Abe’s profound influence on Japan’s immigration regime

How skills from hospitality and tourism can propel careers beyond the industry

Research shows managers of firms handling recalls should review media scrutiny before deciding whether to lobby

New model system for the development of potential active substances used in condensate modifying drugs

How to reduce social media stress by leaning in instead of logging off

Pioneering research shows sea life will struggle to survive future global warming

In 10 seconds, an AI model detects cancerous brain tumor often missed during surgery 

Burden of RSV–associated hospitalizations in US adults, October 2016 to September 2023

Repurposing semaglutide and liraglutide for alcohol use disorder

[Press-News.org] Researchers build 'artificial ovary' to develop oocytes into mature human eggs